-
公开(公告)号:US10995091B2
公开(公告)日:2021-05-04
申请号:US16167084
申请日:2018-10-22
申请人: Proximagen, LLC
发明人: Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号: A61K31/55 , A61K31/551 , A61K31/439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/12 , C07D401/12 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
-
公开(公告)号:US20200262835A1
公开(公告)日:2020-08-20
申请号:US16784320
申请日:2020-02-07
申请人: PROXIMAGEN, LLC
发明人: Max ESPENSEN , Lee PATIENT , David EVANS , Edward SAVORY , Iain SIMPSON
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.
-
公开(公告)号:US10428066B2
公开(公告)日:2019-10-01
申请号:US15911935
申请日:2018-03-05
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Iain Simpson , Edward Savory
IPC分类号: A61K31/40 , C07D471/04 , C07C53/18
摘要: The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.
-
公开(公告)号:US11311552B2
公开(公告)日:2022-04-26
申请号:US15562741
申请日:2016-04-01
申请人: PROXIMAGEN, LLC
IPC分类号: A61K31/551 , A61K9/00 , A61K45/06
摘要: The invention relates to 6-{4-[1-(Propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}-N-(pyridin-4-yl)pyridine-2-carboxamide, or a pharmaceutically acceptable salt thereof, for use in treatment of CNS cancers. The invention also relates to combination treatments with irradiation and/or a chemotherapeutic agent for use in the treatment of cancer.
-
公开(公告)号:US20200147059A1
公开(公告)日:2020-05-14
申请号:US16620373
申请日:2018-06-08
申请人: Proximagen, LLC
发明人: William PULLMAN
IPC分类号: A61K31/437 , A61K31/15 , A61K31/198 , A61K31/165
摘要: Inhibitors of VAP-1/SSAO activity, and pharmaceutical compositions comprising the same, are useful for the prevention and/or treatment of migraine, including headache, chronic migraine, episodic migraine, medication overuse headache disorder (MOU), migraine without aura, migraine with aura, migraine aura without headache, ocular migraine, vestibular migraine, basilar migraine, hemiplegic migraine, ophthalmoplegic migraine, and tension-type headache (TTH).
-
公开(公告)号:US20200002335A1
公开(公告)日:2020-01-02
申请号:US16542792
申请日:2019-08-16
申请人: PROXIMAGEN, LLC
发明人: Max ESPENSEN , Lee PATIENT , David EVANS , Iain SIMPSON , Edward SAVORY
IPC分类号: C07D471/04 , A61K31/40 , C07C53/18
摘要: The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.
-
公开(公告)号:US10155761B2
公开(公告)日:2018-12-18
申请号:US15497324
申请日:2017-04-26
申请人: PROXIMAGEN, LLC
发明人: Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号: A61K31/55 , A61K31/551 , A61K31/439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/12 , C07D401/12 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
-
公开(公告)号:US20230110165A1
公开(公告)日:2023-04-13
申请号:US17962273
申请日:2022-10-07
申请人: Proximagen, LLC
发明人: Max Espensen , Lee Patient , David Evans , Edward Savory , Iain Simpson
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.
-
公开(公告)号:US11512082B2
公开(公告)日:2022-11-29
申请号:US16784320
申请日:2020-02-07
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Edward Savory , Iain Simpson
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.
-
公开(公告)号:US20220348577A1
公开(公告)日:2022-11-03
申请号:US17190266
申请日:2021-03-02
申请人: Proximagen, LLC
发明人: Giles Brown , Michael Higginbottom , Alison Stewart , Lee Patient , Allison Carley , Iain Simpson , Edward Daniel Savory , Kathryn Oliver , Andrew Graham Cole
IPC分类号: C07D471/08 , A61K45/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D401/12 , C07D471/04 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
-
-
-
-
-
-
-
-
-