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公开(公告)号：US20210341554A1
公开(公告)日：2021-11-04
申请号：US17377586
申请日：2021-07-16
摘要： The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.
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公开(公告)号：US11435371B2
公开(公告)日：2022-09-06
申请号：US16463885
申请日：2017-11-23
发明人： Harma Martine Feitsma , Vanda Lucia De Carvalho Vittorino De Almeida , Christianne Rossette Maria De Witz , Matthias Irmscher , Sandra Martina Van Den Bosch
IPC分类号： G01N35/00 , G01N33/543 , G01N33/569 , G01N30/60
摘要： The present invention relates to a device (100) for isolating an analyte (2) from a body fluid sample (4), wherein the analyte (2) is part of a target (6) contained in the body fluid sample (4). The device (100) comprises at least two types of magnetic particles (8, 12) for binding the analyte (2) and/or the target (6), at least three chambers (16, 18, 20) arranged in series to allow controlled movement of the magnetic particles (8, 12) and at least one fluid for releasing the analyte (2) from the target (6).
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公开(公告)号：US11519923B2
公开(公告)日：2022-12-06
申请号：US16307677
申请日：2017-06-19
IPC分类号： G01N35/00
摘要： A system (1) for detecting an analyte of interest in a sample is disclosed that comprises a measurement chamber (21) for metering the sample and including a defined concentration of an activator (27) causing the generation of a product when interacting with the analyte of interest, a heating element (31) thermally coupled to the measurement chamber, a controller (33) adapted to control the heating element such that the measurement chamber is maintained at a defined temperature (Td), a sensor (35) adapted to detect said product, a timer (37) adapted to time an interaction time between the sample and the activator; and a processor (39) responsive to the sensor and the timer. The processor is adapted to, upon addition of the sample to the measurement chamber, determine an amount of the analyte of interest in the sample from a sensor signal indicative of an amount of said product in the measurement chamber provided by the sensor prior to termination of said interaction; known interaction kinetics between the analyte of interest and the activator at the defined temperature and the defined concentration; and the interaction time at time of generation of the sensor signal. A method of detecting an analyte of interest in a sample using such a system is also disclosed.
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公开(公告)号：US20240060971A1
公开(公告)日：2024-02-22
申请号：US18267449
申请日：2021-12-09
发明人： Alexander van Reenen
IPC分类号： G01N33/543 , G01N21/82 , G01N21/27
CPC分类号： G01N33/54333 , G01N21/82 , G01N33/54306 , G01N21/274 , G01N21/552
摘要： Methods and systems are provided for compensating for gravitational and fluid composition effects on a magnetic biosensor system. In one example, a sensor system includes a sample container configured to receive a sample containing an analyte to be tested, the sample container comprising a detection surface and a plurality of signal generating elements in the sample container, wherein the detection surface comprises a binding surface, which has been partially functionalized with capture elements that can bind, directly and/or indirectly, the analyte and/or the plurality of signal generating elements. The sensor system further includes a memory storing instructions executable by a processor to obtain background data comprising sensor signals from one or more background regions of the detection surface, obtain sample data comprising sensor signals from the binding surface, and perform a correction of the sample data based on the background data.
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公开(公告)号：US20240053334A1
公开(公告)日：2024-02-15
申请号：US18258195
申请日：2021-12-09
IPC分类号： G01N33/543 , G01N21/552 , G01N21/01
CPC分类号： G01N33/54333 , G01N21/552 , G01N21/01 , G01N33/54373
摘要： Methods and systems are provided for compensating for gravitational effects on a sensor system. In one example, a sensor system includes a sample container configured to receive a sample containing an analyte to be tested, the sample container comprising a detection surface and a plurality of signal generating elements in the sample container, wherein the detection surface comprises a binding surface, which has been partially functionalized with capture elements that can bind, directly and/or indirectly, the analyte and/or the signal generating elements, wherein the signal generating elements have a spatial distribution profile over the detection surface, wherein the spatial distribution profile has a gradient along a first axis, and wherein the binding surface has an axis of symmetry that is orthogonal to the first axis.
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公开(公告)号：US11519845B2
公开(公告)日：2022-12-06
申请号：US16301990
申请日：2017-05-16
摘要： The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.
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公开(公告)号：US11243199B2
公开(公告)日：2022-02-08
申请号：US14687180
申请日：2015-04-15
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije e/v Wijgergangs , Thea van der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N27/74 , G01N33/543 , B01L3/00 , G01N21/25 , G01N21/45
摘要： The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b). A magnetic field generator is optionally used to generate a magnetic field (B) at the binding surface by which magnetic label particles can be manipulated, for example attracted or repelled.
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公开(公告)号：US11125744B2
公开(公告)日：2021-09-21
申请号：US16308865
申请日：2017-06-26
IPC分类号： G01N33/74 , G01N33/543 , G01N33/574 , G01N33/569
摘要： The present invention relates to a device (100) for detecting an analyte (12) in a body fluid sample (14) containing a plurality of cells (16). The device (100) comprises a sample input (18) for receiving a body fluid sample (14) containing a plurality of cells (16), and an immunoassay unit (20) comprising a detection surface (28) for performing an immunoassay of said body fluid sample (14) containing a plurality of cells (16). The immunoassay unit (20) comprises an activating reagent (22) for activating the plurality of cells (16) contained in the body fluid sample (14) to release an analyte (12), an anti-analyte-antibody (24) capable of binding to said analyte (12) to form a complex (26) comprising said anti-analyte-antibody (24) and said analyte (12), wherein the forming of said complex (26) proceeds at least partially simultaneous to the activating of said plurality of cells (16).
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