公开(公告)号：US11739156B2

公开(公告)日：2023-08-29

申请号：US16735187

申请日：2020-01-06

申请人： The Broad Institute, Inc. ,  Massachusetts Institute of Technology

发明人： Amy Li ,  Rebecca H. Herbst ,  Aviv Regev ,  Tyler Jacks ,  David Canner

IPC分类号： C07K16/28 ,  C07K16/24 ,  C07K16/30 ,  A61P35/00 ,  C12N9/22 ,  A61K39/00 ,  A61K45/06

CPC分类号： C07K16/2866 ,  A61P35/00 ,  C07K16/244 ,  C07K16/30 ,  C12N9/22 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/732

摘要： The present invention discloses novel methods, compositions, and uses thereof for removing or overcoming immunosuppression. More specifically, the methods and compositions disclosed herein target effector Treg cells by modulating ST2 and/or IL-33 signaling using pharmaceutical inhibitors and/or genetic ablation, whereby the levels and/or activities of effector Treg cells in a tumor microenvironment are inhibited, and the infiltration of effector CD8+ cytotoxic T cells into tumor microenvironment increases. As a result, tumor growth is inhibited and tumor volume is reduced. The present invention also provides methods for identifying and isolating effector Treg cells in a population of heterogeneous cells.