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公开(公告)号:US11844816B2
公开(公告)日:2023-12-19
申请号:US17813931
申请日:2022-07-20
申请人: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
发明人: Cindy Liu , Lance B. Price
IPC分类号: A61K35/741 , A61K31/351 , A61K9/00
CPC分类号: A61K35/741 , A61K9/0043 , A61K31/351
摘要: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
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公开(公告)号:US20230094433A1
公开(公告)日:2023-03-30
申请号:US17937117
申请日:2022-09-30
IPC分类号: C12Q1/6853 , C12Q1/686 , C12Q1/6851
摘要: Methods, kits, and oligonucleotides used in the detection of the coronavirus strain, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are disclosed. In some aspects, the oligonucleotides are primers or probes used in the described methods or kits. The oligonucleotide consists of 40 or less nucleotides and has a nucleotide sequence that consists essentially of, or is a variant of, the nucleotide sequence of: SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, or SEQ ID NO:10.
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公开(公告)号:US20230043710A1
公开(公告)日:2023-02-09
申请号:US17931893
申请日:2022-09-13
发明人: David Engelthaler , Jolene Bowers , James Schupp
IPC分类号: C12Q1/6874 , C12Q1/686 , C12Q1/682
摘要: Methods, kits, and oligonucleotides used in the detection of the coronavirus strain, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are disclosed. In some aspects, the oligonucleotides are primers or probes used in the described methods or kits. The oligonucleotide consists of 40 or less nucleotides and has a nucleotide sequence that consists essentially of, or is a variant of, the nucleotide sequence of: SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7. In some embodiments, the oligonucleotide is modified with an internal spacer or a detectable label. For example, the 5′ terminus is labeled with a fluorophore and the 3′ terminus is complexed to a quencher of fluorescence of said fluorophore. In some embodiments, the nucleotide sequence of the oligonucleotide further comprises a universal tail sequence.
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公开(公告)号:US20220325324A1
公开(公告)日:2022-10-13
申请号:US17745832
申请日:2022-05-16
申请人: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
IPC分类号: C12Q1/689 , C12Q1/6883
摘要: The present invention relates to method of detecting and characterizing one or more Borrelia species causing Lyme Disease or tick-borne relapsing fever within a sample from a subject, the method comprising: a) subjecting DNA and/or RNA from the sample to a PCR amplification reaction using primer pairs targeting at least one region of Borrelia 16S rRNA and at least one region of flaB, ospA, ospB, ospC, glpQ, 16S-23S intergenic spacer (IGS1), 5S-23S intergenic spacer (IGS2), bbk32, dbpA, dbpB, and/or p66; and b) analyzing amplification products resulting from the PCR amplification reaction to detect the one or more Borrelia species.
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公开(公告)号:US11186875B2
公开(公告)日:2021-11-30
申请号:US15735289
申请日:2016-06-13
申请人: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人: John Carpten , David Craig , Sara Byron , Jessica Aldrich , Mitesh Borad , Alan Bryce , Michael Barrett , George Vasmatzis , Keith Stewart
IPC分类号: C12Q1/6886 , G01N33/574 , A61K39/395
摘要: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.
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公开(公告)号:US20210298650A1
公开(公告)日:2021-09-30
申请号:US17217711
申请日:2021-03-30
摘要: An application running on a device to manage insulin site rotation may read a configuration file including a group, a plurality of sites in the group, and an image associated with the group. The application may detect an input selecting a site from the plurality of sites for administration of an insulin management device. The application may also set the selected site as unavailable for a predetermined duration in response to the input selecting the site. A log entry may be written to track usage of the site in response to the input selecting the site. A visual indicator on the selected site may show that the site is recently selected in response to detecting the input selecting the site within a predetermined duration. The insulin management device may be a pump, a syringe, or a glucose monitor.
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公开(公告)号:US10550427B2
公开(公告)日:2020-02-04
申请号:US15034544
申请日:2014-11-10
申请人: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
发明人: James M. Schupp , Rebecca E. Colman , David Engelthaler , John Gillece , Nathan Hicks , Paul S. Keim
IPC分类号: C12P19/34 , C12Q1/686 , C12Q1/6874
摘要: Some embodiments of the invention include a method of preparing a sample for sequencing that includes receiving a sample and amplifying at least one marker within the sample. In some embodiments, amplification of the first marker may include mixing the sample with a first oligonucleotide that comprises a first universal tail sequence and a second oligonucleotide that comprises a second universal tail sequence. In some aspects of the invention, the first universal tail sequence and the second universal tail sequence are different sequences.
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公开(公告)号:US10449197B2
公开(公告)日:2019-10-22
申请号:US15740546
申请日:2015-11-25
IPC分类号: A61K31/519 , A61K33/24 , A61K31/282 , A61K31/7068 , A61K45/06 , A61P35/00
摘要: Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB 1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor.
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公开(公告)号:US10385394B2
公开(公告)日:2019-08-20
申请号:US14216618
申请日:2014-03-17
IPC分类号: C12Q1/6883 , G16B30/00
摘要: The present invention relates to processes for characterizing and screening for the existence or predisposition to X-linked disorders associated with changes in X-chromosome inactivation. The present invention also relates to processes of reducing a disease phenotype associated with an X-linked disorder in a female subject.
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公开(公告)号:US20180125846A1
公开(公告)日:2018-05-10
申请号:US15666493
申请日:2017-08-01
申请人: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人: Mitesh Jivraj Borad , David Craig , John Carpten
IPC分类号: A61K31/517 , A61K31/506 , A61K31/5025 , A61K9/00 , A61K31/5377 , C12Q1/6886
CPC分类号: A61K31/517 , A61K9/0053 , A61K31/5025 , A61K31/506 , A61K31/5377 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要: Methods of treating, and for selecting a chemotherapy regimen for treatment of cancer in a patient (FIG. 9). For example, a patient genetic sample from a bilary cancer such as cholangiocarcinoma is analyzed for a mutation in ERRFII and a chemotherapeutic agent is selected as a result of the analysis. If a mutation in ERRFII is present, treatment with an inhibitor of Epidermal Growth Factor Receptor (EGFR) is shown to have inhibitory effects on tumor growth. In this manner, the chemotherapy regimen is targeted to a given mutation in a patient's cancer.
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