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公开(公告)号：US20230139966A1
公开(公告)日：2023-05-04
申请号：US17918160
申请日：2021-04-12
发明人： Hideki Ebihara , Jason A. Tri , Kalpathi L. Venkatachalam , Paul A. Friedman , Christopher V. DeSimone , Daniel C. DeSimone , Martin van Zyl , Adetola O. Ladejobi , Andrew D. Badley , Samuel J. Asirvatham
摘要： Devices and methods are described for disinfection of pathogenic organisms using pulsed DC field electroporation. For example, this disclosure describes disinfection of pathogenic organisms using pulsed DC field electroporation for lung infection treatment, blood infection treatment, sterilization, and respirators.
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公开(公告)号：US20230136935A1
公开(公告)日：2023-05-04
申请号：US17787405
申请日：2020-12-18
发明人： William E. Clifton, III , Aaron C. Damon , Eric W. Nottmeier , Mark A. Pichelmann , Alfredo Quinones-Hinojosa
IPC分类号： G09B23/30 , B33Y10/00 , B01J23/02 , B01J27/232
摘要： Disclosed are a method for creating a surgical training model, a surgical training model apparatus, a bone model, an article that emulates tissue of an animal musculoskeletal system, an article that emulates animal fat tissue, and an article that emulates animal skin tissue. One version of the method comprises placing a spinal vertebrae model in a cavity model that emulates an animal body cavity; forming a first layer on top of the vertebrae model, wherein the first layer emulates an animal muscle tissue; placing a second layer over the first layer, wherein the second layer emulates an animal fat tissue; and placing a third layer over the second layer, wherein the third layer emulates an animal skin tissue. The spinal vertebrae model can be 3D printed from a thermoplastic polymer and infiltrated with a foam into an interior space of the 3D printed spinal vertebrae model.
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公开(公告)号：US20230128765A1
公开(公告)日：2023-04-27
申请号：US17842495
申请日：2022-06-16
IPC分类号： C07D401/04 , C12N9/00 , A61P25/00 , A61P25/16 , A61P35/00 , C07D213/56 , C07D233/64 , C07D235/16 , C07D257/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula I or a compound of Formula II. or pharmaceutically acceptable salts thereof.
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4.发明申请公开(公告)号：US20230126226A1
公开(公告)日：2023-04-27
申请号：US17970771
申请日：2022-10-21
发明人： Iman J. Kalantari , Kia Khezeli
IPC分类号： G06V10/774 , G06V10/776
摘要： In accordance with some embodiments, systems, methods, and media for training a model for improved out of distribution performance are provided. In some embodiments, the method comprises: receiving a plurality of datasets, each associated with a different environment e; initializing data representation parameters associated with a model; providing the datasets as input to the model; receiving, from the model, an output associated with each input; determining an optimal classifier for the data representation parameters using an invariance penalty based on a square root of matrix e(φ):=EXe[(φ(Xe)φ(Xe)T] for e, where φ represents the data representation parameters, and φ(xe) is the dataset associated with environment e modified based on the data representation parameters; calculating a loss value for the optimal classifier across the datasets; and modifying the data representation parameters based on the loss value.
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公开(公告)号：US11634744B2
公开(公告)日：2023-04-25
申请号：US16582042
申请日：2019-09-25
发明人： Veena Taneja
摘要： This document provides methods and materials involved in assessing mammals (e.g., humans) for arthritis. For example, methods and materials for assessing a mammal's gut microbial diversity to identify the mammal as having arthritis (e.g., rheumatoid arthritis) are provided. This document also provides methods and materials involved in treating arthritis.
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公开(公告)号：US11634469B2
公开(公告)日：2023-04-25
申请号：US16916482
申请日：2020-06-30
IPC分类号： C07K14/705 , A61K48/00 , A61K38/21 , C07K14/565 , A61K35/766
摘要： This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.
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公开(公告)号：US20230089991A1
公开(公告)日：2023-03-23
申请号：US18053200
申请日：2022-11-07
摘要： Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.
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公开(公告)号：US20230086332A1
公开(公告)日：2023-03-23
申请号：US17799321
申请日：2021-02-11
发明人： Chengwu Huang , Shigao Chen
摘要： Described here are systems and methods for ultrasound clutter filtering to produce images of blood flow in a subject. The systems and methods described in the present disclosure may be advantageously applied to fast ultrasound imaging techniques, including ultrafast plane wave imaging techniques.
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公开(公告)号：US11604196B2
公开(公告)日：2023-03-14
申请号：US16930790
申请日：2020-07-16
摘要： This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
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公开(公告)号：US11596516B2
公开(公告)日：2023-03-07
申请号：US16902477
申请日：2020-06-16
发明人： Katherine L. Baldwin , James P. Rohl , James K. Cawthra, Jr. , Joseph A. Dearani , Daniel Shuey , Dale Groth
IPC分类号： A61F2/24 , A61B17/122 , A61B17/06 , A61B17/062 , A61B17/04 , A61B17/00 , A61B17/128 , A61B90/00
摘要： A heart valve anchor apparatus may include a body having a proximal portion and a distal portion. The body may include a first radially expandable portion at the proximal portion of the body, a second radially expandable portion at the distal portion of the body, and a root portion extending from the first radially expandable portion to the second radially expandable portion, the root portion having an outer extent. The first radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. The second radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. In an unstressed configuration, the body may define a longitudinal centerline that extends away from a plane tangent to the root portion.
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