公开(公告)号：US20050208015A1

公开(公告)日：2005-09-22

申请号：US10529216

申请日：2003-09-02

申请人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

发明人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

IPC分类号： A61K47/48 ,  A61P43/00 ,  C07C233/78 ,  C07C237/22 ,  C07C323/60 ,  C07D207/40 ,  C07D207/404 ,  A61K38/54 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/48

CPC分类号： C07D207/404 ,  A61K47/54 ,  A61K47/6949 ,  B82Y5/00 ,  C07C233/78 ,  C07C237/22 ,  C07C323/60

摘要： (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.

摘要翻译： （其中R表示包含反应性基团或能够转化成反应性基团的残基的残基; n表示3以上的整数，X表示能够具有以下结构的残基：n为数：R < > 1个各自表示氢原子或能够转化成氢原子的基团，并且6个或更多个R 1可以相同或不同，由 能够在保持生理活性的同时修饰生理活性多肽或其衍生物或低分子化合物的上述式（1），或可用于提高低分子化合物的稳定性或水溶性的上述式（1） 被提供。

公开(公告)号：US07569706B2

公开(公告)日：2009-08-04

申请号：US10529216

申请日：2003-09-02

申请人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

发明人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

IPC分类号： C07D207/08 ,  C07C231/02 ,  C07C29/03

CPC分类号： C07D207/404 ,  A61K47/54 ,  A61K47/6949 ,  B82Y5/00 ,  C07C233/78 ,  C07C237/22 ,  C07C323/60

摘要： (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.

摘要翻译： （其中R表示含有能够转化为反应性基团的反应性基团或基团的残基; n表示3以上的整数，X表示可以具有如下结构的残基数：n表示 氢原子或能够转化成氢原子的基团，6个以上的R 1可以相同也可以不同，上述式（1）表示的化合物能够改变生理活性多肽或 衍生物或低分子化合物，同时保持生理活性，或可用于提高低分子化合物的稳定性或水溶性。