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    Method for purifying protein
    1.
    发明授权
    Method for purifying protein 有权
    蛋白质纯化方法

    公开(公告)号：US09487566B2

    公开(公告)日：2016-11-08

    申请号：US14129677

    申请日：2012-06-28

    申请人： Tsutomu Sugihara ,  Tomoko Isoda ,  Yuya Taniguchi ,  Hidetaka Nomura ,  Toshiyuki Suzawa

    发明人： Tsutomu Sugihara ,  Tomoko Isoda ,  Yuya Taniguchi ,  Hidetaka Nomura ,  Toshiyuki Suzawa

    IPC分类号： C07K1/18 ,  C07K14/47 ,  C07K14/81 ,  C07K1/16

    CPC分类号： C07K14/4703 ,  C07K1/165 ,  C07K1/18 ,  C07K14/8128

    摘要： The present invention relates to protein purification. More particularly, a method for directly recovering an objective protein from a protein composition and purifying a protein with a desired quality in a rapid and efficient manner is provided. Further, a rapid purification method capable of efficiently removing impurities included in the protein composition is provided. Therefore, compared to the conventional purification methods, quality and yield of the protein can be remarkably improved.

    摘要翻译： 本发明涉及蛋白质纯化。 更具体地，提供了一种从蛋白质组合物中直接回收目标蛋白质并以快速且有效的方式纯化具有所需质量的蛋白质的方法。 此外，提供能够有效地除去蛋白质组合物中所含的杂质的快速纯化方法。 因此，与常规的纯化方法相比，可以显着提高蛋白质的质量和产率。

    Peptides
    2.
    发明授权
    Peptides 失效
    多肽

    公开(公告)号：US06872803B1

    公开(公告)日：2005-03-29

    申请号：US09349707

    申请日：1999-07-08

    申请人： Kenji Shibata ,  Toshiyuki Suzawa ,  Motoo Yamasaki ,  Koji Yamada ,  Tatsuhiro Ogawa ,  Takeo Tanaka ,  Shiro Soga

    发明人： Kenji Shibata ,  Toshiyuki Suzawa ,  Motoo Yamasaki ,  Koji Yamada ,  Tatsuhiro Ogawa ,  Takeo Tanaka ,  Shiro Soga

    IPC分类号： C07K14/58 ,  C07K14/745 ,  A61K38/10

    CPC分类号： C07K14/745 ,  C07K14/58

    摘要： The present invention provides peptides represented by the following formula (A): wherein Q represents a physiologically active peptide moiety; X each represents the same or different α-amino acid residue; M represents Gly or Cys; m represents an integer of from 5 to 8; and n represents an integer of from 0 to 3, or their pharmaceutically acceptable salts thereof. The peptides of the present invention have higher stability and/or higher activity than physiologically active linear peptides to which no cyclic peptide is bonded.

    摘要翻译： 本发明提供由下式（A）表示的肽：其中Q表示生理活性肽部分; X各自表示相同或不同的α-氨基酸残基; M表示Gly或Cys; m表示5〜8的整数， 和n表示0〜3的整数，或其药学上可接受的盐。本发明的肽与没有结合肽的生理活性线性肽相比，具有更高的稳定性和/或更高的活性。

    COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE
    8.
    发明申请
    COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE 审中-公开
    用甘油衍生物修饰的化合物

    公开(公告)号：US20100172967A1

    公开(公告)日：2010-07-08

    申请号：US12708714

    申请日：2010-02-19

    申请人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    发明人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    IPC分类号： A61K9/127 ,  C07C237/06 ,  C07F9/06 ,  C07F9/02 ,  C07K2/00 ,  A61K9/107

    CPC分类号： C07D207/452 ,  A61K47/00 ,  A61K47/54 ,  A61K47/6911 ,  B82Y5/00 ,  C07C323/60 ,  C07F9/10 ,  C07K5/0202

    摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R—X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.

    摘要翻译： 本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。 本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基 包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质 和疏水性物质，R-X或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基： 包含该颗粒的细颗粒; 等等。

    Compound modified with glycerol derivative
    9.
    发明授权
    Compound modified with glycerol derivative 失效
    用甘油衍生物修饰的化合物

    公开(公告)号：US07696359B2

    公开(公告)日：2010-04-13

    申请号：US10570623

    申请日：2004-09-03

    申请人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    发明人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    IPC分类号： C07D207/46 ,  C07F9/09

    CPC分类号： C07D207/452 ,  A61K47/00 ,  A61K47/54 ,  A61K47/6911 ,  B82Y5/00 ,  C07C323/60 ,  C07F9/10 ,  C07K5/0202

    摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.

    摘要翻译： 本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。 本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基 包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质 和疏水性物质，至RX或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基： 包含该颗粒的细颗粒; 等等。

    Glycerol derivative
    10.
    发明授权
    Glycerol derivative 失效
    甘油衍生物

    公开(公告)号：US07569706B2

    公开(公告)日：2009-08-04

    申请号：US10529216

    申请日：2003-09-02

    申请人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

    发明人： Hisao Nemoto ,  Motoo Yamasaki ,  Toshiyuki Suzawa ,  Hiroyuki Yamaguchi

    IPC分类号： C07D207/08 ,  C07C231/02 ,  C07C29/03

    CPC分类号： C07D207/404 ,  A61K47/54 ,  A61K47/6949 ,  B82Y5/00 ,  C07C233/78 ,  C07C237/22 ,  C07C323/60

    摘要： (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.

    摘要翻译： （其中R表示含有能够转化为反应性基团的反应性基团或基团的残基; n表示3以上的整数，X表示可以具有如下结构的残基数：n表示 氢原子或能够转化成氢原子的基团，6个以上的R 1可以相同也可以不同，上述式（1）表示的化合物能够改变生理活性多肽或 衍生物或低分子化合物，同时保持生理活性，或可用于提高低分子化合物的稳定性或水溶性。