公开(公告)号：US20060111302A1

公开(公告)日：2006-05-25

申请号：US10994215

申请日：2004-11-19

申请人： Floyd Romesberg ,  Nathaniel David ,  Ryan Cirz

发明人： Floyd Romesberg ,  Nathaniel David ,  Ryan Cirz

IPC分类号： A61K38/05 ,  A61K31/366 ,  G06F19/00 ,  A61K48/00

CPC分类号： C07K14/245 ,  Y02A90/26

摘要： The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of antibiotic resistance. The invention generally involves said administration of achaogens, agents that inhibit said mutational process, to inhibit said evolution of drug resistance. Also, described herein are compositions that are suitable for use as achaogens.

公开(公告)号：US20060286574A1

公开(公告)日：2006-12-21

申请号：US11399294

申请日：2006-04-05

申请人： Floyd Romesberg ,  Ryan Cirz ,  Philip Patten

发明人： Floyd Romesberg ,  Ryan Cirz ,  Philip Patten

IPC分类号： C12Q1/68 ,  A61K31/496 ,  A61K31/4709 ,  C40B30/06

CPC分类号： A61K45/06 ,  A61K31/496 ,  C12Q1/025 ,  C12Q1/18 ,  C12Q1/6813 ,  Y02A50/473 ,  A61K2300/00

摘要： The present invention provides compositions useful in treating drug-resistant microorganisms and cells, as well as related methods of identifying and using such compositions. In addition, the present invention includes compositions useful in enhancing the sensitivity of both drug-resistant and drug-sensitive microorganisms and cells to microbicidal and cytotoxic agents, including antibiotics and chemotherapeutic drugs. Methods of identifying these compositions, as well as methods of using these agents in treating both drug-resistant and drug-sensitive diseases and conditions are further provided.

摘要翻译： 本发明提供了可用于治疗药物抗性微生物和细胞的组合物，以及鉴定和使用这些组合物的相关方法。 此外，本发明包括可用于增强耐药和药物敏感性微生物和细胞对杀微生物剂和细胞毒性剂（包括抗生素和化学治疗药物）的敏感性的组合物。 进一步提供鉴定这些组合物的方法，以及使用这些试剂治疗耐药性和药物敏感性疾病和病症的方法。