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18 条记录 (耗时 0.016 秒)

    Plasminogen-activating substance and the preparation and use of such substance
    2.
    发明授权
    Plasminogen-activating substance and the preparation and use of such substance 失效
    纤溶酶原激活物质及其制备及使用

    公开(公告)号：US4265881A

    公开(公告)日：1981-05-05

    申请号：US130798

    申请日：1980-03-17

    申请人： Ikuo Yamashina ,  Toshisuke Kawasaki ,  Michiko Tsukuda

    发明人： Ikuo Yamashina ,  Toshisuke Kawasaki ,  Michiko Tsukuda

    IPC分类号： C07K1/20 ,  A61K38/00 ,  A61K38/46 ,  A61P7/02 ,  C07K14/435 ,  C12N9/64 ,  A61K35/40

    CPC分类号： C12N9/6421 ,  A61K38/00

    摘要： A new type of plasminogen-activating substance is extracted from the bile of hogs, which substance is characterized by;(A) a molecular weight of 80,000 .+-.10,000;(B) an isoelectric point of 7.1;(C) an ultraviolet absorption spectrum showing a peak (.lambda. max) at a wave length of about 278 nm;(D) a fibrinolysis activity such that a Ca-added standard fibrin plate is lysed but a heated fibrin plate is not lysed;(E) such a high thermal stability that heating at a temperature of 80.degree. C. for 10 minutes causes the plasminogen-activating activity to be decreased to an extent corresponding to 50% of the original activity and heating at a temperature of 60.degree. C. for 30 minutes causes the plasminogen-activating activity to be decreased to an extent corresponding to from 30 to 40% of the original activity;(F) a solubility in a saline solution and an insolubility in water-soluble organic solvents, and;(G) a synthetic substrate-lysis activity such that Glutaryl-Gly-Arg-MCA and Pro-Phe-Arg-MCA are only marginally hydrolysed.

    摘要翻译： 从猪的胆汁中提取新型的纤溶酶原激活物质，其特征在于： （A）分子量为80,000 +/- 10,000; （B）等电点7.1; （C）在波长约278nm处显示出峰值（λmax）的紫外吸收光谱; （D）纤维蛋白溶解活性使得Ca加入的标准纤维蛋白板裂解，但加热的纤维蛋白板不会裂解; （E）如此高的热稳定性，在80℃的温度下加热10分钟，使纤溶酶原激活活性降低至与原始活性的50％相当的程度，并在60℃的温度下加热 30分钟使纤维蛋白溶酶原活化活性降低至相应于原始活性的30％至40％的程度; （F）在盐溶液中的溶解度和在水溶性有机溶剂中的不溶性，和 （G）合成的底物裂解活性，使得Glutaryl-Gly-Arg-MCA和Pro-Phe-Arg-MCA仅略微水解。

    Preparation comprising batroxobin for inhibiting local invasion of malignant tumors
    9.
    发明申请
    Preparation comprising batroxobin for inhibiting local invasion of malignant tumors 有权
    包括巴曲酶用于抑制恶性肿瘤局部浸润的制剂

    公开(公告)号：US20070104706A1

    公开(公告)日：2007-05-10

    申请号：US11638069

    申请日：2006-12-13

    申请人： Hirobumi Senga ,  Yongling Wan ,  Lishui Chang

    发明人： Hirobumi Senga ,  Yongling Wan ,  Lishui Chang

    IPC分类号： A61K38/48

    CPC分类号： A61K38/482

    摘要： A preparation for inhibiting local invasion of malignant tumors is provided which comprises batroxobin and therefore can inhibit local invasion of malignant tumors. A preparation for encapsulating malignant tumor tissues is also provided which comprises batroxobin and therefore can cause or promote formation of capsule-like tissue around malignant tumor tissues.

    摘要翻译： 提供了抑制恶性肿瘤局部浸润的制剂，其包括巴曲酶，因此可以抑制恶性肿瘤的局部侵袭。 还提供了包封恶性肿瘤组织的制剂，其包括巴曲酶，因此可以引起或促进恶性肿瘤组织周围的胶囊样组织的形成。

    Cyclic polyamino containing compounds having therapeutic effect and the preparation thereof
    10.
    发明授权
    Cyclic polyamino containing compounds having therapeutic effect and the preparation thereof 失效
    具有治疗作用的环状含聚氨基化合物及其制备

    公开(公告)号：US4476299A

    公开(公告)日：1984-10-09

    申请号：US401865

    申请日：1982-07-26

    申请人： Hideji Itokawa

    发明人： Hideji Itokawa

    IPC分类号： A61K36/18 ,  A61K38/00 ,  A61P35/00 ,  C07K1/113 ,  C07K7/64 ,  C07K14/415 ,  C07H15/26 ,  C07C103/52

    CPC分类号： C07K7/64 ,  A61K38/00 ,  Y10S930/27

    摘要： New compounds of the following general formula: ##STR1## wherein R.sub.1 is acyl, alkyl, cycloalkyl, carboxyalkyl or ester thereof, heterocyclic group, saccharide residue or hydrogen atom, R.sub.2 stands for hydrogen atom or a lower alkyl and R.sub.3 represents hydrogen atom or a nitrogen-containing group,are provided, among these, some of the compounds to be isolated and purified from a plant belonging to Genus Rubia, other compounds being prepared by chemically modifying the isolated compounds with various kind of substituents and these new compounds having therapeutic effect, in particular such as antineoplastic, emetic, anorexigenic, psychotropic, vasoconstrictive, papaverinic, antiperkinsonian and/or antidiuretic effect.

    摘要翻译： 下列通式的新化合物：其中R1是酰基，烷基，环烷基，羧基烷基或酯，杂环基，糖残基或氢原子，R2代表氢原子或低级烷基，R3代表氢 原子或含氮基团，其中包括从属于茜草属的植物中分离和纯化的一些化合物，通过用各种取代基化学改性分离的化合物制备的其它化合物，以及这些新化合物 具有治疗效果，特别是抗肿瘤药，止吐药，厌食症，精神药物，血管收缩剂，罂粟碱，抗帕金森和/或抗利尿作用。