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    Noninvasive dermal anesthetics
    3.
    发明授权
    Noninvasive dermal anesthetics 失效
    无创皮肤麻醉药

    公开(公告)号：US5919479A

    公开(公告)日：1999-07-06

    申请号：US819880

    申请日：1997-03-18

    申请人： Jie Zhang ,  Hao Zhang

    发明人： Jie Zhang ,  Hao Zhang

    IPC分类号： A61M37/00 ,  A61F7/02 ,  A61F7/03 ,  A61F13/00 ,  A61K9/70 ,  A61K31/167 ,  A61K31/245 ,  A61L15/42 ,  A61L15/44 ,  A61P23/00

    CPC分类号： A61F7/034 ,  A61K31/167 ,  A61K31/216 ,  A61K31/245 ,  A61K9/7023 ,  A61F2007/0261 ,  A61F2013/00187 ,  A61F2013/00204 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61M37/00 ,  Y10S514/817 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944

    摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.

    摘要翻译： 一种用于改善药物皮肤渗透的装置，产品制剂和方法，其中所述装置包括薄的药物制剂储存器和由第一不可渗透壁分隔开的发热室，其中所述储存器和室由 住房。 药物制剂储存器容纳或能够容纳预定量的含有药物活性剂的制剂。 发热/温度调节室包括用于产生受控热的介质，优选由碳，铁，水和/或盐制成的化学组成，其在与空气（氧气）接触时被活化。 发热/温度调节元件的功能是加热使用者的皮肤，迅速使皮肤温度达到所需和升高的窄范围，并将其保持在该范围内足够的时间以获得更快速，增强和更少变化的皮肤 吸收所选的药物活性剂并获得改善的临床效果。 还公开了用于控制发热的结构。 该装置可以可选地包括跨越药物制剂储存器在不可渗透的壁和使用者的皮肤表面之间的间隔或间隔结构，用于维持用户皮肤表面上的药物制剂的预定厚度。 另外，可以与使用高百分比的局部麻醉剂共晶混合物的装置一起使用的新产品制剂来降低在待水解的制剂中的局部麻醉剂的总体降解速率。

    Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
    4.
    发明申请
    Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same 有权
    用于皮肤递送药物的粘合剂剥离形成剂及其使用方法

    公开(公告)号：US20050276842A1

    公开(公告)日：2005-12-15

    申请号：US11146917

    申请日：2005-06-06

    申请人： Jie Zhang ,  Kevin Warner ,  Michael Ashburn ,  Larry Rigby ,  Suyi Niu

    发明人： Jie Zhang ,  Kevin Warner ,  Michael Ashburn ,  Larry Rigby ,  Suyi Niu

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7015 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/445 ,  A61K31/573 ,  A61K47/10 ,  A61K47/32

    摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.

    摘要翻译： 本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。 制剂可以包括药物，溶剂载体和剥离形成剂。 溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性 对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效率递送。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

    Adhesive solid gel-forming formulations for dermal drug delivery
    6.
    发明申请
    Adhesive solid gel-forming formulations for dermal drug delivery 审中-公开
    用于皮肤药物递送的粘合剂固体凝胶形成配方

    公开(公告)号：US20070280972A1

    公开(公告)日：2007-12-06

    申请号：US11796145

    申请日：2007-04-25

    申请人： Jie Zhang ,  Kevin Warner ,  Sanjay Sharma

    发明人： Jie Zhang ,  Kevin Warner ,  Sanjay Sharma

    IPC分类号： A61K47/06 ,  A61K31/07 ,  A61K31/4439 ,  A61K47/10 ,  A61K47/14 ,  A61K47/46 ,  A61P17/06 ,  A61P25/30 ,  A61P31/22 ,  A61P25/00 ,  A61P17/00 ,  A61K47/18 ,  A61K47/12 ,  A61K31/56 ,  A61K31/59

    CPC分类号： A61K9/7015 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/07 ,  A61K31/192 ,  A61K31/196 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/485 ,  A61K31/522 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/59 ,  A61K47/10

    摘要： The present invention is drawn to adhesive solid gel-forming formulations, methods of drug delivery, and solidified gel layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a gelling agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein at least one non-volatile solvent is flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified gel layer after at least a portion of the volatile solvent system is evaporated. The solidified gel layer is can be removed by either peeling or washing using a designated solvent or solvents.

    摘要翻译： 本发明涉及粘合剂固体凝胶形成制剂，药物递送方法和用于药物真皮递送的固化凝胶层。 制剂可以包括药物，溶剂载体和胶凝剂。 溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂的非挥发性溶剂 ），其能够在持续的时间段内以治疗有效率促进药物的递送。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成凝固的凝胶层。 固化的凝胶层可以通过使用指定的溶剂或溶剂的剥离或洗涤来除去。