公开(公告)号：US06998235B2

公开(公告)日：2006-02-14

申请号：US10170356

申请日：2002-06-14

申请人： James L. Kennedy ,  Pierandrea Muglia

发明人： James L. Kennedy ,  Pierandrea Muglia

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2525/151 ,  C12Q2600/156

摘要： Methods and kits for determining susceptibility of a patient to bipolar disorders are described. The method comprises the steps of: (a) obtaining a sample from a patient; and (b) testing the sample for the presence of a polymorphism selected from (i) a 2 repeat allele in the variable number of tandem repeat (VNTR) region of the DRD4 gene and (ii) a 4 repeat allele in the VNTR region of the DRD4 gene, wherein the presence of the 2 repeat allele indicates that the patient is less susceptible to a bipolar disorder and the presence of the 4 repeat allele indicates that the patient is more susceptible to a bipolar disorder.

公开(公告)号：US07091401B2

公开(公告)日：2006-08-15

申请号：US10324131

申请日：2002-12-20

申请人： Maurice M. Moloney ,  Gijs Van Rooijen

发明人： Maurice M. Moloney ,  Gijs Van Rooijen

IPC分类号： C12N15/82 ,  C12N15/18 ,  C12N15/62 ,  A01H5/00 ,  A01H5/10

CPC分类号： C12N9/6483 ,  C07K14/415 ,  C07K14/545 ,  C07K14/61 ,  C07K14/8139 ,  C07K14/815 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/6429 ,  C12N15/8222 ,  C12N15/8234 ,  C12N15/8241 ,  C12N15/8242 ,  C12N15/8257 ,  C12Y304/21005 ,  C12Y304/23004

摘要： The present invention provides a method of preparing epidermal growth factors in plants and transgenic plant seeds containing epidermal growth factors. The method provides an economical way to produce epidermal growth factors.

公开(公告)号：US07060789B1

公开(公告)日：2006-06-13

申请号：US10089058

申请日：2000-10-04

申请人： Curtis Braun ,  Admir Purac ,  Thor Borgford

发明人： Curtis Braun ,  Admir Purac ,  Thor Borgford

IPC分类号： C07K1/00 ,  A61K39/00

CPC分类号： C07K14/415 ,  A61K38/00 ,  Y02A50/471

摘要： The present invention provides a protein having chain of a ricin-like toxin, a B chain of a ricin-like toxin and a novel heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a specific protease such as those found in inflammatory cells and cancer cells. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying cells having a specific protease, such as cancer cells or inflammatory cells utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human inflammation and cancer.

摘要翻译： 本发明提供了连接A链和B链的蛋白质，其具有蓖麻毒蛋白样毒素链，蓖麻毒蛋白样毒素的B链和新的异源连接体氨基酸序列。 接头序列含有特异性蛋白酶的切割识别位点，例如在炎症细胞和癌细胞中发现的那些。 本发明还涉及编码蛋白质的核酸分子和掺入核酸分子的表达载体。 还提供了利用本发明的核酸分子和蛋白质以及用于治疗人类炎症和癌症的药物组合物来抑制或破坏具有特定蛋白酶的细胞如癌细胞或炎性细胞的方法。