公开(公告)号：US07171311B2

公开(公告)日：2007-01-30

申请号：US10342887

申请日：2003-01-15

申请人： Hongyue Dai ,  Yudong He ,  Peter S. Linsley ,  Mao Mao ,  Christopher J. Roberts ,  Laura Johanna Van't Veer ,  Marc J. Van de Vijver ,  Rene Bernards ,  A. A. M. Hart

发明人： Hongyue Dai ,  Yudong He ,  Peter S. Linsley ,  Mao Mao ,  Christopher J. Roberts ,  Laura Johanna Van't Veer ,  Marc J. Van de Vijver ,  Rene Bernards ,  A. A. M. Hart

IPC分类号： G01N33/48 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.

摘要翻译： 本发明涉及其表达与乳腺癌相关的遗传标记。 具体地，本发明提供了一组标志物，其表达模式可用于区分与乳腺癌相关的临床病症，例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在，并提供关于肿瘤可能性的信息 初步诊断五年内远处转移。 本发明涉及使用这些标记来区分这些条件的方法。 本发明还提供了基于预后对患者进行分类和治疗的方法。 本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的诊断，预后和统计学方法进行数据分析的计算机软件。