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公开(公告)号:US20110301048A1
公开(公告)日:2011-12-08
申请号:US12953314
申请日:2010-11-23
申请人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A.A. M. Hart
发明人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A.A. M. Hart
CPC分类号: C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G06F19/00 , G16B25/00 , G16B40/00 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
摘要翻译: 本发明涉及其表达与乳腺癌相关的遗传标记。 具体地,本发明提供了一组标志物,其表达模式可用于区分与乳腺癌相关的临床病症,例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在,并提供关于肿瘤可能性的信息 初步诊断五年内远处转移。 本发明涉及使用这些标记来区分这些条件的方法。 本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的统计学方法进行数据分析的计算机软件。
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公开(公告)号:US20140047329A1
公开(公告)日:2014-02-13
申请号:US13572082
申请日:2012-08-10
IPC分类号: G06F17/21
CPC分类号: G06F16/9577
摘要: A system includes a first computing device that includes a memory configured to store instructions. The first computing device also includes a processor to execute the instructions to perform a method that includes receiving one or more environment characteristics of a communication connection between a user device and a font provider. The method also includes determining an appropriate amount of font information of a web asset to provide to the user device based upon the one or more environment characteristics, and, providing the appropriate amount of font information of the web asset to the user device for presenting the web asset.
摘要翻译: 系统包括第一计算设备,其包括被配置为存储指令的存储器。 第一计算设备还包括执行指令以执行包括接收用户设备和字体提供者之间的通信连接的一个或多个环境特性的方法的处理器。 该方法还包括基于一个或多个环境特征来确定要提供给用户设备的网页资产的适当数量的字体信息,以及向用户设备提供适当量的网页资产的字体信息,以呈现 网络资产。
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公开(公告)号:US07171311B2
公开(公告)日:2007-01-30
申请号:US10342887
申请日:2003-01-15
申请人: Hongyue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A. A. M. Hart
发明人: Hongyue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A. A. M. Hart
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.
摘要翻译: 本发明涉及其表达与乳腺癌相关的遗传标记。 具体地,本发明提供了一组标志物,其表达模式可用于区分与乳腺癌相关的临床病症,例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在,并提供关于肿瘤可能性的信息 初步诊断五年内远处转移。 本发明涉及使用这些标记来区分这些条件的方法。 本发明还提供了基于预后对患者进行分类和治疗的方法。 本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的诊断,预后和统计学方法进行数据分析的计算机软件。
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公开(公告)号:US20130215126A1
公开(公告)日:2013-08-22
申请号:US13399146
申请日:2012-02-17
IPC分类号: G06T1/00
CPC分类号: G06F17/214 , G06Q30/06
摘要: A system includes a first computing device that includes a memory configured to store instructions. The first computing device also includes a processor to execute the instructions to perform a method that includes receiving, at a font service provider, a request from a second computing device for one or more fonts. The method also includes authenticating the user of the second computing device from the received request, and, providing access to data representative of the one or more fonts identified in the received request for use by the second computing device. The data representative of the one or more fonts resides in a predefined portion of memory assigned to the user of the second computing device.
摘要翻译: 系统包括第一计算设备,其包括被配置为存储指令的存储器。 第一计算设备还包括执行指令以执行方法的处理器,该方法包括在字体服务提供者处从一个或多个字体接收来自第二计算设备的请求。 该方法还包括从接收到的请求中认证第二计算设备的用户,以及提供访问表示在所接收的请求中标识以供第二计算设备使用的一个或多个字体的数据。 表示一个或多个字体的数据驻留在分配给第二计算设备的用户的存储器的预定义部分中。
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公开(公告)号:US07863001B2
公开(公告)日:2011-01-04
申请号:US12214878
申请日:2008-06-23
申请人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A. M. Hart
发明人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A. M. Hart
CPC分类号: C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G06F19/00 , G06F19/20 , G06F19/24 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
摘要翻译: 本发明涉及其表达与乳腺癌相关的遗传标记。 具体地,本发明提供了一组标志物,其表达模式可用于区分与乳腺癌相关的临床病症,例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在,并提供关于肿瘤可能性的信息 初步诊断五年内远处转移。 本发明涉及使用这些标记来区分这些条件的方法。 本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的统计学方法进行数据分析的计算机软件。
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公开(公告)号:US07514209B2
公开(公告)日:2009-04-07
申请号:US10172118
申请日:2002-06-14
申请人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A. M. Hart
发明人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A. M. Hart
CPC分类号: C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G06F19/00 , G06F19/20 , G06F19/24 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
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公开(公告)号:US06221597B1
公开(公告)日:2001-04-24
申请号:US09315793
申请日:1999-05-21
IPC分类号: C12Q168
CPC分类号: C12Q1/18 , C40B40/00 , G01N33/5097 , G01N2500/00
摘要: The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticides, herbicides and anti-proliferation drugs. The present invention provides antisense molecules and ribozymes comprising sequences complementary to the sequences of mRNAs of essential genes that function to inhibit the essential genes. The present invention also provides neutralizing antibodies to proteins encoded by essential genes that bind to and inactivate the essential gene products. The present invention further provides pharmaceutical compositions for treating fungal and proliferative diseases, as well as methods of treatment of fungal and proliferative diseases.
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公开(公告)号:US20140153012A1
公开(公告)日:2014-06-05
申请号:US13692593
申请日:2012-12-03
IPC分类号: G06F3/12
CPC分类号: G06F3/121 , G06F3/1229 , G06F3/1234 , G06F3/1288 , G06F3/1292 , G06F17/214
摘要: A system includes a computing device that includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include receiving a request from an imaging device indicating that the imaging device is unable to present textual content of an asset. The request includes one or more attributes of the textual content of the asset and the request is sent from the imaging device absent user input. Operations also include identifying an appropriate amount of font information from the received one or more attributes for the imaging device to present the asset, and, providing the identified font information to the imaging device for presenting the asset.
摘要翻译: 系统包括计算设备,其包括被配置为存储指令的存储器。 计算设备还包括执行指令以执行操作的处理器,该操作包括从成像设备接收指示成像设备不能呈现资产的文本内容的请求。 该请求包括资产的文本内容的一个或多个属性,并且该请求是从没有用户输入的成像设备发送的。 操作还包括从所接收的一个或多个属性识别适当数量的字体信息以用于成像设备呈现资产,以及将所识别的字体信息提供给成像设备以呈现资产。
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公开(公告)号:US20090157326A1
公开(公告)日:2009-06-18
申请号:US12214878
申请日:2008-06-23
申请人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A.M. Hart
发明人: HongYue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , Augustinus A.M. Hart
IPC分类号: G06F19/00
CPC分类号: C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G06F19/00 , G06F19/20 , G06F19/24 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
摘要翻译: 本发明涉及其表达与乳腺癌相关的遗传标记。 具体地,本发明提供了一组标志物,其表达模式可用于区分与乳腺癌相关的临床病症,例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在,并提供关于肿瘤可能性的信息 初步诊断五年内远处转移。 本发明涉及使用这些标记来区分这些条件的方法。 本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的统计学方法进行数据分析的计算机软件。
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公开(公告)号:US06612339B1
公开(公告)日:2003-09-02
申请号:US10034980
申请日:2001-12-28
IPC分类号: F16L5504
CPC分类号: B60T8/368 , B60T8/4275 , B60T11/236 , F15B1/24 , F15B2201/21 , F15B2201/312 , F15B2201/61
摘要: A piston for a low pressure fluid accumulator of a hydraulic control unit of a vehicle brake system includes a cylindrical body having an outer surface defining a first end surface of the piston. The first end surface includes a plurality of interconnected ridges. The ridges have outer surfaces and form cavities therebetween. Each ridge is adapted to provide a sealing surface between the first end surface of the piston and an inner surface of a fluid accumulator in which the piston may be inserted. In one embodiment of the invention, the closed end of the piston includes a thick self-supporting wall. A thin skirt extends from the thick self-supporting wall toward the open end of the piston. A plurality of axially extending skirt support ribs is formed on the inner surface of the piston skirt.
摘要翻译: 用于车辆制动系统的液压控制单元的低压流体储存器的活塞包括具有限定活塞的第一端面的外表面的圆筒体。 第一端面包括多个互连脊。 脊具有外表面并且在它们之间形成空腔。 每个脊适于在活塞的第一端面和活塞可以插入其中的流体储存器的内表面之间提供密封表面。 在本发明的一个实施例中,活塞的封闭端包括厚的自支撑壁。 薄裙从厚的自支撑壁向活塞的开口端延伸。 多个轴向延伸的裙部支撑肋形成在活塞裙的内表面上。
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