公开(公告)号：US11738000B2

公开(公告)日：2023-08-29

申请号：US16988525

申请日：2020-08-07

申请人： Biomedical Analysis Center, Academy Of Military Medical Sciences ,  Institute Of Pharmacology And Toxicology, Academy Of Military Medical Sciences

发明人： Xuemin Zhang ,  Xinhua He ,  Tao Zhou ,  Zhenggang Liu ,  Tao Li

IPC分类号： A61K31/09 ,  A61K31/23 ,  A61K31/325 ,  C07C69/78 ,  C07C271/44 ,  C07C69/28 ,  C07D265/30 ,  C07C271/56 ,  A61K31/222 ,  C07C69/16 ,  A61P37/04 ,  A61P35/04 ,  A61K31/135

CPC分类号： A61K31/325 ,  A61K31/09 ,  A61K31/135 ,  A61K31/222 ,  A61K31/23 ,  A61P35/04 ,  A61P37/04 ,  C07C69/16 ,  C07C69/28 ,  C07C69/78 ,  C07C271/44 ,  C07C271/56 ,  C07D265/30

摘要： Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I,




wherein X is C═O or CH2; Y is NH, O or absent; R is: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T1/2=12-24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoids environmental oxidation and increase the environmental stability of drugs containing the compounds.

公开(公告)号：US20210008022A1

公开(公告)日：2021-01-14

申请号：US16988525

申请日：2020-08-07

申请人： Biomedical Analysis Center, Academy Of Military Medical Sciences ,  Institute Of Pharmacology And Toxicology, Academy Of Military Medical Sciences

发明人： Xuemin ZHANG ,  Xinhua HE ,  Tao ZHOU ,  Zhenggang LIU ,  Tao LI

IPC分类号： A61K31/325 ,  A61K31/23 ,  C07C69/78 ,  C07C271/44 ,  C07C69/28 ,  C07D265/30 ,  C07C271/56 ,  A61K31/222 ,  C07C69/16 ,  A61P37/04 ,  A61P35/04 ,  A61K31/09 ,  A61K31/135

摘要： Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C═O or CH2; Y is NH, O or absent; R is: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T1/2=12-24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoids environmental oxidation and increase the environmental stability of drugs containing the compounds.

公开(公告)号：US10786481B2

公开(公告)日：2020-09-29

申请号：US16069814

申请日：2017-02-22

申请人： Biomedical Analysis Center, Academy of Military Medical Sciences ,  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

发明人： Xuemin Zhang ,  Xinhua He ,  Tao Zhou ,  Zhenggang Liu ,  Tao Li

IPC分类号： A61K31/325 ,  A61K31/23 ,  A61K31/135 ,  C07C69/78 ,  C07C271/44 ,  C07C69/28 ,  C07D265/30 ,  C07C271/56 ,  A61K31/222 ,  C07C69/16 ,  A61P37/04 ,  A61P35/04 ,  A61K31/09

摘要： Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C═O or CH2; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.

公开(公告)号：US20190022049A1

公开(公告)日：2019-01-24

申请号：US16069814

申请日：2017-02-22

申请人： Biomedical Analysis Center, Academy Of Military Medical Sciences ,  Institute Of Pharmacology And Toxicology, Academy Of Military Medical Sciences

发明人： Xuemin ZHANG ,  Xinhua HE ,  Tao ZHOU ,  Zhenggang LIU ,  Tao LI

IPC分类号： A61K31/325 ,  A61K31/23 ,  A61K31/135 ,  A61K31/09 ,  A61P35/04 ,  A61P37/04

摘要： Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C═O or CH2; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.

公开(公告)号：US20230405041A1

公开(公告)日：2023-12-21

申请号：US18460637

申请日：2023-09-04

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES, ACADEMY OF MILITARY SCIENCES OF CHINESE PLA ,  BEIJING JIUYU ONCOLGY CO LTD

发明人： Zhiqiang LIU ,  Zengqiang YUAN ,  Xiaowen XING ,  Bingshui XIU ,  Shihong LIU

IPC分类号： A61K31/728 ,  A61P25/28

CPC分类号： A61K31/728 ,  A61P25/28

摘要： An application of hyaluronic acid in preparing medicines for preventing or treating ferroptosis-related diseases is provided, and an application of hyaluronic acid or salts of hyaluronic acid or derivatives of hyaluronic acid in preparing medicines for inhibiting ferroptosis is also provided. According to the present application, the anti-ferroptosis function of hyaluronic acid is disclosed. The hyaluronic acid is the first natural extracellular matrix material with anti-ferroptosis function found at present. The hyaluronic acid is one of the components of natural extracellular matrix and exists in large quantities in human body and is also a widely used material in clinic.

公开(公告)号：US20230293485A1

公开(公告)日：2023-09-21

申请号：US18017471

申请日：2021-07-22

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Ruiyuan Cao ,  Manli Wang ,  Wei Li ,  Lei Zhao ,  Jingjing Yang ,  Yuexiang Li ,  Shiyong Fan ,  Xinbo Zhou ,  Dian Xiao ,  Zhihong Hu ,  Song Li ,  Wu Zhong

IPC分类号： A61K31/366 ,  A61P31/14 ,  A61K31/365 ,  A61K31/357

CPC分类号： A61K31/366 ,  A61P31/14 ,  A61K31/365 ,  A61K31/357

摘要： The present invention relates to an application of an artemisinin compound in treatment of coronavirus infection. Specifically, the present invention provides an application of the compound, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof in preparation of medicines. The medicines are used for treating diseases or infection caused by coronavirus (preferably SARS-CoV-2), and the compound is selected from one or more of artemisinin, arteether, artemether, artemisia ketone, dihydroartemisinin, artesunate, arteannuin B, and artemisinic acid.

公开(公告)号：US20230279337A1

公开(公告)日：2023-09-07

申请号：US17996710

申请日：2021-04-23

申请人： Academy of Military Medical Sciences, AMS, PLA

发明人： Jun WU ,  Bo LIU ,  Peng SUN ,  Xin GONG ,  Tiantian WANG ,  Xuchen HOU ,  Bin ZHANG

IPC分类号： C12N1/16 ,  C12N15/52

CPC分类号： C12N1/165 ,  C12N15/52

摘要： The present invention discloses a method for constructing an engineered yeast for glycoprotein preparation and strains thereof. The present invention provides a method for constructing yeast engineered strain having the ability to modify a specific mammalian cell glycoform, comprising: inactivating endogenous α-1,6-mannose transferase, phosphomannose transferase, phosphomannose synthase, β-mannose transferase I-IV, and O-mannose transferase I of a receptore yeast; and expressing exogenous mannosidase I, N-acetylglucosamine transferase I, mannosidase II, N-acetylglucosamine transferase II, galactose isomerase and exogenous galactose transferase. The yeast engineered strain obtained in the present invention features a short construction period, fast growth, easy large-scale production, and high safety, so that they can not only be used to prepare common glycoprotein vaccines, but also very suitable for the efficient research and development and large-scale production of vaccines under emergency conditions such as sudden new infectious diseases. This has important implications in terms of medicinal uses.

公开(公告)号：US20230271970A1

公开(公告)日：2023-08-31

申请号：US18018012

申请日：2021-07-22

申请人： SICHUAN UNIVERSITY ,  ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Yong Qin ,  Wu Zhong ,  Fei Xue ,  Minjie Zhang ,  Shiyong Fan ,  Zhibing Zheng ,  Song Li

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to the technical field of chemical drug synthesis, and specifically relates to a method for preparing a compound as shown in formula I, comprising: treating the compound as shown in formula VII with an acid to generate the compound as shown in formula I. The method has few synthetic process steps, raw materials which is stable and is easy to prepare, a reaction process which is easy to control, and a high overall yield and purity, and is suitable for industrial preparation.

公开(公告)号：US20230263811A1

公开(公告)日：2023-08-24

申请号：US18017710

申请日：2021-07-19

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Yong Qin ,  Manli Wang ,  Ruiyuan Cao ,  Shiyong Fan ,  Zhihong Hu ,  Song Li

IPC分类号： A61K31/00 ,  A61K45/06 ,  A61P31/14

CPC分类号： A61K31/658 ,  A61K45/06 ,  A61P31/14

摘要： The present application relates to use of cannabidiol in the preparation of a drug for treating coronavirus infections. The present invention specifically relates to cannabidiol, or a geometric isomer, pharmaceutically acceptable salt, solvate or hydrate thereof, or use of a pharmaceutical composition comprising any one or more of the above components in the preparation of a drug for preventing and/or treating diseases or infections caused by a coronavirus.

公开(公告)号：US20230218606A1

公开(公告)日：2023-07-13

申请号：US17795471

申请日：2020-06-02

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Leike Zhang ,  Ruiyuan Cao ,  Wei Li ,  Shiyong Fan ,  Xinbo Zhou ,  Song Li

IPC分类号： A61K31/4706 ,  A61P31/14

CPC分类号： A61K31/4706 ,  A61P31/14

摘要： Disclosed are hydroxychloroquine or chloroquine, or a geometric isomer thereof, or a pharmaceutically acceptable salt thereof, and/or a solvate thereof, and/or a hydrate thereof, and a pharmaceutical composition containing the above-mentioned compound, and the use thereof in the treatment of diseases or infections caused by SARS-CoV-2.