公开(公告)号：US20230293485A1

公开(公告)日：2023-09-21

申请号：US18017471

申请日：2021-07-22

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Ruiyuan Cao ,  Manli Wang ,  Wei Li ,  Lei Zhao ,  Jingjing Yang ,  Yuexiang Li ,  Shiyong Fan ,  Xinbo Zhou ,  Dian Xiao ,  Zhihong Hu ,  Song Li ,  Wu Zhong

IPC分类号： A61K31/366 ,  A61P31/14 ,  A61K31/365 ,  A61K31/357

CPC分类号： A61K31/366 ,  A61P31/14 ,  A61K31/365 ,  A61K31/357

摘要： The present invention relates to an application of an artemisinin compound in treatment of coronavirus infection. Specifically, the present invention provides an application of the compound, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof in preparation of medicines. The medicines are used for treating diseases or infection caused by coronavirus (preferably SARS-CoV-2), and the compound is selected from one or more of artemisinin, arteether, artemether, artemisia ketone, dihydroartemisinin, artesunate, arteannuin B, and artemisinic acid.

公开(公告)号：US20210220377A1

公开(公告)日：2021-07-22

申请号：US17070271

申请日：2020-10-14

申请人： Academy of Military Medical Sciences

发明人： Wu ZHONG ,  Ruiyuan Cao ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Leike Zhang ,  Wei Li ,  Yuexiang Li ,  Lei Zhao ,  Shiyong Fan ,  Song Li

IPC分类号： A61K31/685 ,  A61P31/14

摘要： The present application relates to use of a substituted aminopropionate compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for the treatment of a disease or an infection caused by a SARS-CoV-2.

公开(公告)号：US20230077704A1

公开(公告)日：2023-03-16

申请号：US17794145

申请日：2020-07-15

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Ruiyan Cao ,  Leike Zhang ,  Wei Li ,  Yuexiang Li ,  Lei Zhao ,  Song Li

IPC分类号： A61K31/426 ,  A61P31/14

摘要： Nitazoxanide represented by formula I and an active form thereof, tizoxanide compound, represented by formula II, a geometric isomer thereof and pharmaceutically acceptable salt thereof and/or solvate thereof and/or hydrate thereof, and a pharmaceutical composition containing this compound, used for preventing and/or treating coronavirus (such as SARS-CoV-2) infection.