公开(公告)号：US11065232B2

公开(公告)日：2021-07-20

申请号：US16498697

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John Duffield ,  Anant Pandya

IPC分类号： A61K31/4375

摘要： This invention relates to pharmaceutical compositions containing (−)-β-dihydrotetrabenazine, processes for making them and their therapeutic uses.

公开(公告)号：US10660885B2

公开(公告)日：2020-05-26

申请号：US15939826

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John Duffield ,  Anant Pandya

IPC分类号： A61K9/20 ,  A61K9/48 ,  A61K31/473 ,  A61P25/14 ,  C07D471/04 ,  C07D455/06 ,  A61K9/28

摘要： The invention provides (+)-α-dihydrotetrabenazine succinate salt.Also provided are (+)-α-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-α-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-α-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome.The invention further provides a method for preparing the (+)-α-dihydrotetrabenazine succinate salt.

公开(公告)号：US20220016107A1

公开(公告)日：2022-01-20

申请号：US17385450

申请日：2021-07-26

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John DUFFIELD ,  Anant PANDYA

IPC分类号： A61K31/473 ,  C07D471/04 ,  C07D455/06 ,  A61K9/28 ,  A61P25/14 ,  A61K9/20

摘要： The invention provides (+)-α-dihydrotetrabenazine succinate salt.
Also provided are (+)-α-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-α-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-α-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome.
The invention further provides a method for preparing the (+)-α-dihydrotetrabenazine succinate salt.

公开(公告)号：US20200038384A1

公开(公告)日：2020-02-06

申请号：US16498697

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John DUFFIELD ,  Anant PANDYA

IPC分类号： A61K31/4375

摘要： This invention relates to pharmaceutical compositions containing (−)-β-dihydrotetrabenazine, processes for making them and their therapeutic uses.

公开(公告)号：US11844794B2

公开(公告)日：2023-12-19

申请号：US17385450

申请日：2021-07-26

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John Duffield ,  Anant Pandya

IPC分类号： A61K31/473 ,  A61K9/20 ,  A61K9/48 ,  A61P25/14 ,  C07D455/06 ,  C07D471/04 ,  A61K9/28

CPC分类号： A61K31/473 ,  A61K9/20 ,  A61K9/2846 ,  A61P25/14 ,  C07D455/06 ,  C07D471/04 ,  A61K9/48

摘要： The invention provides (+)-α-dihydrotetrabenazine succinate salt.
Also provided are (+)-α-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-α-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-α-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome.
The invention further provides a method for preparing the (+)-α-dihydrotetrabenazine succinate salt.

公开(公告)号：US11844786B2

公开(公告)日：2023-12-19

申请号：US15939828

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John Duffield ,  Anant Pandya

IPC分类号： A61K31/4375 ,  A61P25/14 ,  A61K31/435

CPC分类号： A61K31/435 ,  A61P25/14 ,  A61K2300/00

摘要： The invention relates to pharmaceutical compositions containing both (+)-α-dihydrotetrabenazine and (−)-α-dihydrotetrabenazine and their therapeutic uses, for example in the treatment of movement disorders, such as Tourette's syndrome.

公开(公告)号：US20180280374A1

公开(公告)日：2018-10-04

申请号：US15939822

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John DUFFIELD ,  Anant PANDYA

IPC分类号： A61K31/473 ,  A61P25/14

摘要： This invention relates to the use of low doses of (+)-α-dihydrotetrabenazine for the treatment of movement disorders, such as Tourette's syndrome.

公开(公告)号：US20180280361A1

公开(公告)日：2018-10-04

申请号：US15939837

申请日：2018-03-29

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John DUFFIELD ,  Anant PANDYA

IPC分类号： A61K31/435 ,  A61P25/14

摘要： This invention relates to the use of combinations of stereoisomers of dihydrotetrabenazine for the treatment of movement disorders, such as Tourette's syndrome.

公开(公告)号：US20230331667A1

公开(公告)日：2023-10-19

申请号：US18299191

申请日：2023-04-12

申请人： Adeptio Pharmaceuticals Limited

发明人： Kishor Bapu Gavhane ,  Nitin Punjaji Lad ,  Ramakrishna Guduru ,  Sunit Ramesh Kulkarni

IPC分类号： C07C313/20 ,  B01J27/128

CPC分类号： C07C313/20 ,  B01J27/128

摘要： This invention relates to a novel process for making dihydrotetrabenazines, and in particular (+)-α-dihydrotetrabenazine, novel synthetic intermediates for use in the process and processes for making the intermediates.

公开(公告)号：US11103498B2

公开(公告)日：2021-08-31

申请号：US16852008

申请日：2020-04-17

申请人： ADEPTIO PHARMACEUTICALS LIMITED

发明人： Andrew John Duffield ,  Anant Pandya

IPC分类号： A61K9/48 ,  A61K9/20 ,  A61K9/28 ,  A61P25/14 ,  C07D471/04 ,  C07D455/06 ,  A61K31/473

摘要： The invention provides (+)-α-dihydrotetrabenazine succinate salt.
Also provided are (+)-α-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-α-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-α-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome.
The invention further provides a method for preparing the (+)-α-dihydrotetrabenazine succinate salt.