公开(公告)号：US20240002521A1

公开(公告)日：2024-01-04

申请号：US18253469

申请日：2021-11-19

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  ALDERAAN BIOTECHNOLOGY ,  UNIVERSITE D'AIX MARSEILLE ,  UNIVERSITÉ DE PARIS ,  UNIVERSITE PARIS EST CRETEIL VAL DE MARNE ,  AL DE LA RECHERCHE SCIENTIFIQUE

发明人： Daniel OLIVE ,  Armand BENSUSSAN ,  Jérôme GIUSTINIANI ,  Anne MARIE-CARDINE ,  Amaud FOUSSAT ,  Jemila HOUACINE

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/732

摘要： Novel anti-human CD25 antibodies and their use for treating cancer and infectious diseases. Also, a nucleic acid encoding an anti-human CD25 antibody or an antigen-binding fragment thereof, and a fusion protein including an isolated anti-human CD25 antibody or an antigen-binding fragment thereof. Further, a pharmaceutical composition including an isolated anti-human CD25 antibody or an antigen-binding fragment thereof.

公开(公告)号：US20220251232A1

公开(公告)日：2022-08-11

申请号：US17612347

申请日：2020-05-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICAL) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ D'AIX MARSEILLE ,  UNIVERSITE DE PARIS ,  ALDERAAN BIOTECHNOLOGY ,  UNIVERSITE PARIS EST CRETEIL VAL DE MARNE

发明人： Daniel OLIVE ,  Armand BENSUSSAN ,  Jérôme GIUSTINIANI ,  Arnaud FOUSSAT

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/63

摘要： Novel anti-CD25 antibodies and antigen-bind fragments thereof that do not inhibit the binding of interleukin-2 (IL-2) to CD25, and the use thereof for treating cancer or an infectious disease. Also, fusion proteins including the antibodies and antigen-bind fragments, nucleic acids encoding the antibodies and antigen-bind fragments, and an expression vectors including the nucleic acids. Further, pharmaceutical compositions including the fusion proteins or the antibodies and antigen-bind fragments.