公开(公告)号：US20230157581A1

公开(公告)日：2023-05-25

申请号：US17533479

申请日：2021-11-23

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE PARIS ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE ,  SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY ,  ECOLE PRATIQUE DES HAUTES ETUDES ,  SORBONNE UNIVERSITE ,  UNIVERSITE DE PARIS-SACLAY

发明人： Christophe Goupil ,  Philippe Lecoeur ,  Vincent BELS ,  Eric HERBERT ,  Henni OUERDANE

IPC分类号： A61B5/11 ,  G16H20/30 ,  A61B5/0205

CPC分类号： A61B5/1118 ,  G16H20/30 ,  A61B5/0205

摘要： The present invention relates to a method of determining metabolic parameters of one or several muscular motor units by coupling muscular response to ventilatory response of a subject, comprising, from a step of performing efforts (i) using a test device by the subject moving on the test device; (ii)-a step of instantaneously measuring the movement speed of one or several muscular motor units of the subject v(t), and the oxygen flow rate φO2t); (iii)-a step of plotting the COT curve of the oxygen flow rate of the subject against the movement speed of one or several muscular motor units of the subject v(t), (iv)-a step of determining the following metabolic parameters from the COT curve: Basal power B which is the vertical asymptote at the origin, Flow resistance RM which is the oblique asymptote at high intensities.

公开(公告)号：US20240075063A1

公开(公告)日：2024-03-07

申请号：US18256788

申请日：2021-12-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE PARIS ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS

发明人： Sophie CAILLAT-ZUCMAN ,  Nana TALVARD-BALLAND

IPC分类号： A61K35/17 ,  A61P35/02

CPC分类号： A61K35/17 ,  A61P35/02 ,  A61K2035/124

摘要： The inventors explored in an allogeneic situation the regulatory potential of Mucosal-Associated Invariant T cells (MAIT cells), a population of unconventional T cells that exhibit potent antibacterial activity, expressing a semi-invariant TCR which recognizes vitamin B2 derivatives of microbial origin presented by the MR1 molecule. In particular, the inventors used i) an allogenic reaction model in vitro (mixed lymphocyte reaction, MLR) and ii) murine model of xenogeneic aGvHD They first verified that human MAIT cells do not proliferate in response to allogeneic stimulation in vitro (MLR) or in vivo (immunodeficient mice) alone but require for their expansion both an inflammatory environment and TCR ligation by its ligand. In contrast, MAIT cells are able to inhibit the proliferation of allospecific LT in vitro in a dose-dependent manner. Furthermore, the adoptive transfer of MAIT cells in a mouse model of xeno-GVHD resulted in a delay in early or late GvHD development. Altogether, these data describe a new regulatory function of MAIT cells in an allogeneic context, allowing us to consider their use in cell therapy to limit GvHD.

公开(公告)号：US20230296708A1

公开(公告)日：2023-09-21

申请号：US17697492

申请日：2022-03-17

申请人： Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  Univ Paris XIII Paris-Nord Villetaneuse ,  Universite de Paris

发明人： Giacomo Annio ,  Verena Muller-Reinwald ,  Ralph Sinkus ,  Omar Darwish ,  Wilfried Schnell ,  Tamara Elisabeth Falkner ,  Ahmed M. Gharib

IPC分类号： A61B6/04 ,  A61B5/055

CPC分类号： A61B6/0487 ,  A61B5/055 ,  G01R33/48

摘要： The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.

公开(公告)号：US20230167415A1

公开(公告)日：2023-06-01

申请号：US17593446

申请日：2020-03-27

申请人： INSTITUT PASTEUR ,  UNIVERSITE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Nathalie PARDIGON ,  Justine BASSET ,  Félix Augusto REY

IPC分类号： C12N7/00 ,  C07K14/005

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N2770/24134 ,  C12N2770/24122 ,  C12N2770/24171

摘要： The application relates to the attenuation of a flavivirus, such as a West Nile Virus (WNV), Zika virus (ZIKV), Japanese Encephalitis Virus (JEV), Dengue Virus (DV), in particular DV4, or Usutu virus. The application notably provides a live and attenuated flavivirus, such as a live and attenuated WNV or ZIKV, comprising a mutated M protein. Said mutated M protein comprises or consists of a sequence, wherein at least the amino acids at positions 36 and 43 in said sequence are mutated. The application also provides embodiments deriving from said live and attenuated flavivirus, such as a WNV or ZIKV, such as nucleic acids, cells, cDNA clones, immunogenic compositions as well as uses and methods.

公开(公告)号：US11609124B2

公开(公告)日：2023-03-21

申请号：US17487313

申请日：2021-09-28

申请人： UNIVERSITE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SORBONNE UNIVERSITE

发明人： Marc Guillon ,  Gilles Tessier ,  Tengfei Wu ,  Pascal Berto

IPC分类号： G01J9/00 ,  G06T7/32 ,  G06T7/50 ,  G06T7/37 ,  H04N5/232 ,  G02B5/30 ,  H04N5/225

摘要： A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation Δαij defined by Δαij=arccos, where “·” stands for the inner product between and .

公开(公告)号：US11521745B2

公开(公告)日：2022-12-06

申请号：US16763815

申请日：2018-11-14

申请人： Universite Paris-SUD ,  Universite De Paris ,  Institut National De Sport De L'Expertise Et De La Performance ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Geoffroy Berthelot ,  Jérôme Dedecker ,  Guillaume Sauliere

IPC分类号： G01N33/48 ,  G01N33/50 ,  G16H50/20 ,  G16H50/30 ,  G06F17/18 ,  A61B5/00

摘要： The invention proposes a new method for monitoring a health event in a mammal, comprising detecting at least one abnormal value within a series of values related to at least one biomarker, based on appropriate Z-scores.

公开(公告)号：US20220346748A1

公开(公告)日：2022-11-03

申请号：US17763268

申请日：2020-09-25

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE PARIS ,  SORBONNE UNIVERSITÉ ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELES DE LA VILLE DE PARIS

发明人： Mathieu PERNOT ,  Thomas DEFFIEUX ,  Mickael TANTER ,  Clément PAPADACCI

IPC分类号： A61B8/08 ,  A61B8/00 ,  G16H50/20 ,  G16H20/10 ,  G01S15/89

摘要： Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

公开(公告)号：US20220333177A1

公开(公告)日：2022-10-20

申请号：US17613990

申请日：2020-05-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  PARIS SCIENCES ET LETTRES ,  UNIVERSITE DE PARIS

发明人： Yannick RONDELEZ ,  Guillaume GINES ,  Roberta LIMA DE CASTRO MENEZES ,  Valérie TALY

IPC分类号： C12Q1/6848 ,  C12Q1/6886

摘要： The present invention relates to a digital method for detecting and/or quantifying at least one target biomolecules in a sample, said biomolecules being selected from DNA, RNA, and proteins based on isothermal amplification. The present invention further relates to different applications of the digital method and to a kit.

公开(公告)号：US20220266249A1

公开(公告)日：2022-08-25

申请号：US17596986

申请日：2020-06-26

申请人： PARIS SCIENCES ET LETTRES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  SORBONNE UNIVERSITE ,  UNIVERSITE DE PARIS

发明人： Gaël RADOU ,  Thibault VIEILLE ,  Vincent CROQUETTE

IPC分类号： B01L3/00 ,  B01L9/00 ,  G01B7/30 ,  G01D5/14 ,  G02B21/02 ,  G02B21/26

摘要： A device positioning an object according to a given direction, including a frame, a holderfor holding the object, the holder being movable relative to the frame according to the given directio, a main lever extending between a first point and a second point, said main lever being rotatably mounted to the frame via a first pivot link connecting the main lever and the frame at the first point of the main lever, the main lever being connected to the holder at a third point which is arranged between the first point and the second point, so that a displacement of the second point of the main lever relative to the frame according to the given direction causes displacement of the holder in said given direction.

公开(公告)号：US20220236276A1

公开(公告)日：2022-07-28

申请号：US17616519

申请日：2020-06-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS ,  UNIVERSITE DE PARIS ,  ASSOCIATION GERCOR ,  VERACYTE

发明人： Fabienne HERMITTE ,  Dewi VERNEREY ,  Julie HENRIQUES ,  Thierry ANDRE ,  Julien TAIEB ,  Franck PAGES ,  Jérôme GALON ,  Aurélie CATTEAU

IPC分类号： G01N33/574 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282 ,  A61K45/06

摘要： The present invention relates to methods for determining, modulating or adjusting a treatment regimen with a chemotherapeutic agent in a patient affected with a cancer.