公开(公告)号：US20210353590A1

公开(公告)日：2021-11-18

申请号：US17320543

申请日：2021-05-14

Applicant: Ambe Phytoextracts Pvt. Ltd.

Inventor： Harshpal Singh ,  Kul Bhaskar Singh ,  Shashi Chandrama Singh ,  Muskan Choudhary

IPC: A61K31/365 ,  A61K36/19 ,  A61K47/69 ,  A61K9/16

Abstract: A bioactive formulation including ethanolic concentrates of Andrographolide extract in range of 90% by wt-99% by wt and aqueous 2 hydroxypropyl beta cyclodextrin in the range of 2% by wt-10% by wt. A method for preparation of the bioactive formulation including the following steps: mixing Andrographolide extract and ethanol to prepare ethanolic concentrates of Andrographolide (solvent A), mixing hydroxypropyl beta cyclodextrin and ethanol to obtain an ethanolic concentrate 2 hydroxypropyl beta cyclodextrin (Solvent B), mixing the solvent A and solvent B to obtain a complex concentrate solution, recovering ethanol solvent from the concentrate solution through distillation to obtain a thick paste of the concentrate, drying the paste at a temperature in the range of 55° C.-65° C. and pressure in the range of −650 to 700 mm Hg to obtain a dried complex concentrate followed by converting into an amorphous powder to obtain a bioactive formulation.

公开(公告)号：US20240165182A1

公开(公告)日：2024-05-23

申请号：US18515367

申请日：2023-11-21

Applicant: AMBE PHYTOEXTRACTS PVT. LTD.

Inventor： Harshpal Singh ,  Kul Bhaskar Singh ,  Shashi Chandrama Singh ,  Muskan Choudhary ,  Shipra Agrawal

IPC: A61K36/15 ,  A61K31/192 ,  A61K31/353

CPC classification number: A61K36/15 ,  A61K31/192 ,  A61K31/353 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53 ,  A61K2236/55

Abstract: A method for synthesis of method of extraction of proanthocyanidins compound from pine bark—of Pinus roxburghii comprising the steps: weighing and pulverizing bark to obtain pulverized powder, adding powder with water in steam jacketed rotary extractor to obtain an extract A, adding the residue in the extractor to obtain extract B, processing the second residue to obtain a third residue and an extract C which is further processed to obtain a third residue and extract D, mixing A, B, C, D extract to obtain liquor, subjecting vacuum concentrate and insoluble concentrate and subjecting to spray drying and vacuum drying respectively, sieving the powder followed by sterilization to obtain the Pine Bark Extract and further subjecting to HPLC analysis for proanthocyanidins content and packing the extract into fiber drums with double polybags for storage.