公开(公告)号：US20240325474A1

公开(公告)日：2024-10-03

申请号：US18193054

申请日：2023-03-30

Applicant: Daniel Benjamin ,  Dianne Denommee ,  David Lorchak

Inventor： Daniel Benjamin ,  Dianne Denommee ,  David Lorchak

IPC: A61K36/03 ,  A61K31/365 ,  A61K31/737 ,  A61K36/19 ,  A61P31/14

CPC classification number: A61K36/03 ,  A61K31/365 ,  A61K31/737 ,  A61K36/19 ,  A61P31/14 ,  A61K2236/13 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/35

Abstract: The present invention provides alternate means in form of a medicinal composition comprising botanical extracts comprised of an organic liquid extract derived from Laminaria japonica and an organic liquid extract derived from Andrographis paniculate along with other components as disclosed herein for the prevention of viral binding, uptake, replication, infection, and disease caused by viral pathogens. Combined the aforementioned organic botanical extracts produce strong additivity and synergistic effect against the viral pathogens contributing towards significant reduction in viral binding, uptake, replication, infection, and disease. Also disclosed are the methods to formulate the aforementioned medicinal composition and dosage forms for use in a method for prophylactic treatment and prevention of viral binding, uptake, replication, infection, and disease caused by viral pathogens in an individual, which is also disclosed herein.

公开(公告)号：US12102619B2

公开(公告)日：2024-10-01

申请号：US17841167

申请日：2022-06-15

Applicant: Jazz Pharmaceuticals Research UK Limited

Inventor： Geoffrey Guy ,  Volker Knappertz ,  Eduardo Dunayevich ,  David Critchley

IPC: A61K31/436 ,  A61K31/05 ,  A61K36/185

CPC classification number: A61K31/436 ,  A61K31/05 ,  A61K36/185 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/333 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

公开(公告)号：US20240245741A1

公开(公告)日：2024-07-25

申请号：US18690952

申请日：2022-09-12

Applicant: Minasolve SAS ,  Avignon University

Inventor： Boutheina KHADHRAOUI ,  Markus NAHRWOLD ,  Farid CHEMAT ,  Anne-Sylvie FABIANO TIXIER ,  Karine RUIZ

IPC: A61K36/185 ,  A61K8/9789 ,  A61Q19/00

CPC classification number: A61K36/185 ,  A61K8/9789 ,  A61Q19/00 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/53 ,  A61K2800/10 ,  A61K2800/30

Abstract: The current invention relates to a method for extracting biological material for obtaining cosmetic and/or pharmaceutical components in the obtained extract using an extraction solvent, comprising the steps of contacting the biological material with the extraction solvent, immersing the biological material in the extraction solvent, macerating or percolating or infusing the mixture, filtering and/or centrifuging the extraction product obtained, thereby obtaining a liquid extract, wherein said extraction solvent comprises water and one or a plurality of alkane diols with 5 through 12 carbon atoms. The invention also relates to a cosmetic preparation and use of a composition.

公开(公告)号：US12029772B2

公开(公告)日：2024-07-09

申请号：US17706865

申请日：2022-03-29

Applicant: Mustafa Barzani ,  Shireen Nature Company for General Trading, Ltd.

Inventor： Mustafa Barzani

IPC: A61K36/00 ,  A61K9/00 ,  A61K9/48 ,  A61K31/192 ,  A61K31/353 ,  A61K31/427 ,  A61K31/4965 ,  A61K31/513 ,  A61K31/517 ,  A61K31/675 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/7068 ,  A61K36/76 ,  A61K38/17 ,  A61K38/21 ,  A61K39/395 ,  A61K39/42 ,  A61P31/14

CPC classification number: A61K36/76 ,  A61K9/0053 ,  A61K9/48 ,  A61K31/192 ,  A61K31/353 ,  A61K31/427 ,  A61K31/4965 ,  A61K31/513 ,  A61K31/517 ,  A61K31/675 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/7068 ,  A61K38/1774 ,  A61K38/21 ,  A61K39/3955 ,  A61K39/42 ,  A61P31/14 ,  A61K2236/15 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53

Abstract: The invention provides therapeutic compositions containing willow extract, such as willow leaf extract, methods of medical treatment using such compositions, and methods for preparing such compositions.

公开(公告)号：US20240216452A1

公开(公告)日：2024-07-04

申请号：US18545273

申请日：2023-12-19

Applicant: Man Ki HWANG

Inventor： Man Ki HWANG

IPC: A61K36/232 ,  A61K31/473 ,  A61K36/21 ,  A61K36/234 ,  A61K36/254 ,  A61K36/284 ,  A61K36/324 ,  A61K36/328 ,  A61K36/344 ,  A61K36/40 ,  A61K36/46 ,  A61K36/481 ,  A61K36/484 ,  A61K36/53 ,  A61K36/64 ,  A61K36/65 ,  A61K36/734 ,  A61K36/752 ,  A61K36/815 ,  A61K36/8945 ,  A61K36/8998 ,  A61K36/9064

CPC classification number: A61K36/232 ,  A61K31/473 ,  A61K36/21 ,  A61K36/234 ,  A61K36/254 ,  A61K36/284 ,  A61K36/324 ,  A61K36/328 ,  A61K36/344 ,  A61K36/40 ,  A61K36/46 ,  A61K36/481 ,  A61K36/484 ,  A61K36/53 ,  A61K36/64 ,  A61K36/65 ,  A61K36/734 ,  A61K36/752 ,  A61K36/815 ,  A61K36/8945 ,  A61K36/8998 ,  A61K36/9064 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/39

Abstract: Disclosed herein is a method for manufacturing a composition promoting bone density enhancement, the method including preparing a mixture of Angelica gigas, Cnidium officinale, Phlomis umbrosa, Astragalus membranceus, Amomi fructus, Citri unshius pericarpium, Drynariae rhizoma, Codonopsis pilosulae radix, frankincense, and myrrh, aging the mixture, drying the mixture and grinding the dried mixture into a powder, and extracting a liquid from the powder.

公开(公告)号：US20240216451A1

公开(公告)日：2024-07-04

申请号：US18390276

申请日：2023-12-20

Applicant: Man Ki Hwang

Inventor： Man Ki Hwang

IPC: A61K36/232 ,  A61K36/126 ,  A61K36/234 ,  A61K36/324 ,  A61K36/328 ,  A61K36/344 ,  A61K36/481 ,  A61K36/53 ,  A61K36/752 ,  A61K36/9064 ,  A61P19/00

CPC classification number: A61K36/232 ,  A61K36/126 ,  A61K36/234 ,  A61K36/324 ,  A61K36/328 ,  A61K36/344 ,  A61K36/481 ,  A61K36/53 ,  A61K36/752 ,  A61K36/9064 ,  A61P19/00 ,  A61K2236/15 ,  A61K2236/333

Abstract: Disclosed herein is a method for manufacturing a composition promoting recovery from a bone fracture, the method including preparing a mixture of Angelica gigas, Cnidium officinale, Phlomis umbrosa, Astragalus membranceus, Amomi fructus, Citri unshius pericarpium, Drynariae Rhizoma, Codonopsis Pilosulae Radix, frankincense, and myrrh, aging the mixture, smoking the mixture, drying the mixture and grinding the dried mixture into a powder, and extracting a liquid from the powder.

公开(公告)号：US20240207219A1

公开(公告)日：2024-06-27

申请号：US18392419

申请日：2023-12-21

Applicant: Worcester Polytechnic Institute ,  The Penn State Research Foundation

Inventor： Scarlet S. Shell ,  Pamela Weathers ,  Joshua J. Kellogg

IPC: A61K31/352 ,  A61K36/282 ,  A61K45/06 ,  A61K49/00 ,  A61P31/06

CPC classification number: A61K31/352 ,  A61K36/282 ,  A61K45/06 ,  A61K49/0008 ,  A61P31/06 ,  A61K2236/15 ,  A61K2236/39

Abstract: Artemisia annua and A. afra dichloromethane extracts contain bactericidal activity against Mycobacterium tuberculosis (Mtb) strain mc26230 under natural infection stress conditions: carbon source metabolism (glycerol, dextrose, and cholesterol) and hypoxia. Significant bactericidal activity against Mtb was observed regardless of carbon source. Extracts from A. afra showed the highest bactericidal activity against Mtb for tested carbon sources, and A. annua bactericidal activity was greatest against Mtb in minimal media with glycerol. A. annua and A. afra. extracts were bactericidal against Mtb under hypoxic conditions. Growth was halted and viability diminished several logs-fold under hypoxic conditions in the presence of each extract. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb than artemisinin, indicative of phytochemicals in A. afra with unique modes of action. Biochemometric analysis of A. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230.

公开(公告)号：US12011472B2

公开(公告)日：2024-06-18

申请号：US17831063

申请日：2022-06-02

Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.

Inventor： Han-Chung Cheng ,  Shun-Chieh Yang ,  An-Ling Cheng

IPC: A61K36/185 ,  A61K31/192 ,  A61P3/00

CPC classification number: A61K36/185 ,  A61K31/192 ,  A61P3/00 ,  A61K2236/15 ,  A61K2236/331

Abstract: A use of a ramie extract in preparing a composition for anti-aging is provided. The composition containing ramie extract can improve the function and activity of mitochondria and telomerase and protect mitochondria from oxidative stress, including decrease in the proton leakage, increase in the ATP production, increase in the spare respiratory capacity, increase in the maximal respiratory capacity, or increase in the ATP coupling efficiency.

公开(公告)号：US20240173373A1

公开(公告)日：2024-05-30

申请号：US18429853

申请日：2024-02-01

Applicant: Desert Harvest, Inc.

Inventor： Heather Florio

IPC: A61K36/886

CPC classification number: A61K36/886 ,  A61K2236/13 ,  A61K2236/15 ,  A61K2236/31 ,  A61K2236/51 ,  A61K2236/53

Abstract: The invention includes a novel method, systems, and compositions for generating a concentrated Aloe vera extract. Embodiments include method, systems, and compositions for extracting a pharmaceutically active polysaccharidic substance from the Aloe plant. Additional embodiments may include therapeutic uses of the concentrated Aloe vera extract for the treatment of one or more diseases and conditions, including interstitial cystitis (IC).

公开(公告)号：US20240165182A1

公开(公告)日：2024-05-23

申请号：US18515367

申请日：2023-11-21

Applicant: AMBE PHYTOEXTRACTS PVT. LTD.

Inventor： Harshpal Singh ,  Kul Bhaskar Singh ,  Shashi Chandrama Singh ,  Muskan Choudhary ,  Shipra Agrawal

IPC: A61K36/15 ,  A61K31/192 ,  A61K31/353

CPC classification number: A61K36/15 ,  A61K31/192 ,  A61K31/353 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53 ,  A61K2236/55

Abstract: A method for synthesis of method of extraction of proanthocyanidins compound from pine bark—of Pinus roxburghii comprising the steps: weighing and pulverizing bark to obtain pulverized powder, adding powder with water in steam jacketed rotary extractor to obtain an extract A, adding the residue in the extractor to obtain extract B, processing the second residue to obtain a third residue and an extract C which is further processed to obtain a third residue and extract D, mixing A, B, C, D extract to obtain liquor, subjecting vacuum concentrate and insoluble concentrate and subjecting to spray drying and vacuum drying respectively, sieving the powder followed by sterilization to obtain the Pine Bark Extract and further subjecting to HPLC analysis for proanthocyanidins content and packing the extract into fiber drums with double polybags for storage.