Process for Preparation of Thiocyclam Base and Salt

    公开(公告)号:US20210321613A1

    公开(公告)日:2021-10-21

    申请号:US17251005

    申请日:2019-06-12

    IPC分类号: A01N43/32 C07D341/00

    摘要: A process for preparation of thiocyclam base and salt. A method of manufacturing N,N-dimethyl-1,2,3-trithian-5-ylainine hydrochloride is described including the steps of: providing a mixture of thiosulfuric acid S, S′[2-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; adding an aqueous saline solution to the mixture of thiosulfuric acid S, S′-[2-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; separating the phases of the mixture; collecting the solids from the mixture using filtration; washing the solids with organic solvent; and drying the solids, where the dried solids are methyl-1,2,3-trithian-5-ylamine hydrochloride, and where the yield of the N,N-dimethyl-1,2,3-trithian-5-ylamine hydrochloride is increased by incorporation of a body charge of diatomaceous earth into the saline addition step, forming a mixture of the diatomaceous C earth with the composition of this step, and filtering the charged mixture through a diatomaceous earth media prior to the separation step.

    Process for preparation of O,O dimethyl phosphoramidothioate and N-(methoxymethylsulfanylphosphoryl) acetamide

    公开(公告)号:US11198700B2

    公开(公告)日:2021-12-14

    申请号:US16860182

    申请日:2020-04-28

    IPC分类号: C07F9/24 A01N57/28

    摘要: Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PCl3 to form PSCl3, reacting the PSCl3 formed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH2Cl2, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH2Cl2. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CH2Cl2 at all times.

    Flucarbazone sodium hemihydrate method and composition

    公开(公告)号:US10827756B1

    公开(公告)日:2020-11-10

    申请号:US16961377

    申请日:2019-01-23

    摘要: A flucarbazone sodium hemihydrate method and composition. A method of suppressing growth of grass and broadleaf weeds is described including applying to said weeds at least one dust-free composition comprising flucarbazone sodium-hemihydrate as an active ingredient. A method for preparing flucarbazone sodium-hemihydrate is also described including treating 4,5-dihydro-3-methoxy-4-methyl-5-oxo-N-[[2-(trifluoromethoxy)phenyl]sulfonyl]-1H-1,2,4-triazole-1-carboxamide (MSU) with aqueous sodium hydroxide under pH-controlled conditions; and confirming that a hemihydrate flucarbazone sodium has been obtained.

    PROCESS FOR PREPARATION OF O, O-DIMEHYL PHOSPHORAMIDOTHIOATE AND N-(METHOXY-METHYLSULFANYLPHOSPHORYL) ACETAMIDE

    公开(公告)号:US20200024293A1

    公开(公告)日:2020-01-23

    申请号:US16040136

    申请日:2018-07-19

    IPC分类号: C07F9/24

    摘要: Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PCl3 to form PSCl3, reacting the PSCl3 formed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH2Cl2, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH2Cl2. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos, and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CH2Cl2 at all times.

    Method of Controlling Anthracnose on Tropical Fruit Plants

    公开(公告)号:US20190223444A1

    公开(公告)日:2019-07-25

    申请号:US15877522

    申请日:2018-01-23

    IPC分类号: A01N47/44 A01N43/88 A01N25/04

    摘要: A method of controlling anthracnose caused by Colletotrichum on tropical fruits, tropical fruit plants or cultivars or plant parts or locus thereof is described. The method comprises the steps of contacting the tropical fruit plant or cultivar in need of treatment with an agrochemical composition comprising an effective amount of a guanidine or a salt and/or solvate thereof. The contacting step may be repeated one or more times at a fixed interval. The guanidine may be dodine, iminoctadine trialbesilate, iminoctadine triacetate, guazatine, salts and/or solvates of any of the foregoing and combinations of one or more of the foregoing.