公开(公告)号：US11459301B2

公开(公告)日：2022-10-04

申请号：US17054853

申请日：2019-05-13

Applicant: ACLIPSE ONE, INC.

Inventor： Ning Shan

IPC: C07D221/18 ,  A61P25/28

Abstract: The invention is directed to a novel crystalline S-apomorphine hydrochloride hydrate salt.

公开(公告)号：US20210353613A1

公开(公告)日：2021-11-18

申请号：US17286799

申请日：2019-10-18

Applicant: Aclipse One Inc. ,  The University of Sheffield

Inventor： Ning Shan ,  Pamela Jean Shaw ,  Claude Ogoe ,  Laura Ferraiuolo

IPC: A61K31/473 ,  A61P25/28

Abstract: The invention is directed to (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H- dibenzo[de,g]quinoline-10,11-diol for the treatment of diseases mediated by protein misfolding of Cu/Zn Superoxide Dismutase (SOD1) or mediated by astrocyte toxicity affecting motor neuron survival.

公开(公告)号：US20220313682A1

公开(公告)日：2022-10-06

申请号：US17633143

申请日：2020-08-07

Applicant: Aclipse One Inc.

Inventor： Ning Shan

IPC: A61K31/473 ,  A61K47/40 ,  A61K47/02 ,  A61K47/10

Abstract: This invention relates to pharmaceutical compositions for enhancing the solubility of (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol and salt forms thereof.

公开(公告)号：US20230141988A1

公开(公告)日：2023-05-11

申请号：US17633150

申请日：2020-08-07

Applicant: Aclipse One Inc.

Inventor： Ning Shan

IPC: A61K31/473 ,  A61K9/00

CPC classification number: A61K31/473 ,  A61K9/0056 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/006

Abstract: The present invention relates to pharmaceutical compositions for administration to mammals that include (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient that provides pharmacokinetic profiles useful for the treatment of neurodegenerative diseases.

公开(公告)号：US20240180908A1

公开(公告)日：2024-06-06

申请号：US18553533

申请日：2022-03-30

Applicant: ACLIPSE ONE, INC.

Inventor： Ning Shan ,  Ira N. Kalfus

IPC: A61K31/506 ,  A61K31/4439 ,  A61P13/12

CPC classification number: A61K31/506 ,  A61K31/4439 ,  A61P13/12

Abstract: Disclosed herein are thiazolidinediones for the treatment of kidney diseases, glomerular diseases, and nephrotic syndrome.

公开(公告)号：US20220265635A1

公开(公告)日：2022-08-25

申请号：US17286797

申请日：2019-10-18

Applicant: Aclipse One Inc. ,  The University of Sheffield

Inventor： Richard James Mead ,  Pamela Jean Shaw ,  Claude Ogoe ,  Ning Shan ,  Laura Ferraiuolo

IPC: A61K31/473 ,  A61P25/28

Abstract: The invention is directed to 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol for the treatment of diseases mediated by protein misfolding, heat shock factor 1 pathways, or nuclear erythroid 2-related factor 2 pathways.

公开(公告)号：US20210214310A1

公开(公告)日：2021-07-15

申请号：US17054853

申请日：2019-05-13

Applicant: ACLIPSE ONE, INC.

Inventor： Ning SHAN

IPC: C07D221/18

Abstract: The invention is directed to a novel crystalline S-apomorphine hydrochloride hydrate salt.