公开(公告)号：US20090081697A1

公开(公告)日：2009-03-26

申请号：US12314007

申请日：2008-12-02

Applicant: Ada Yonath ,  Francois Franceschi ,  Joerg Harm ,  Frank Schluenzen ,  Raz Zarivach ,  Anat Bashan ,  Renate Albrecht

Inventor： Ada Yonath ,  Francois Franceschi ,  Joerg Harm ,  Frank Schluenzen ,  Raz Zarivach ,  Anat Bashan ,  Renate Albrecht

IPC: G01N33/53 ,  G06G7/58

CPC classification number: G01N33/6803 ,  C07K2299/00 ,  G01N33/554 ,  G01N2333/195

Abstract: Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, coordinates defining the 3D atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.

Abstract translation: 公开了生长游离和抗生素复合的大核糖体亚基的晶体的方法，定义其3D原子结构的坐标和利用这种坐标来合理设计或鉴定具有所需特征的抗生素或大核糖体亚基的方法。

公开(公告)号：US20120316106A1

公开(公告)日：2012-12-13

申请号：US13519862

申请日：2010-12-29

Applicant: Ada Yonath ,  Chen Davidovich ,  Ella Zimmerman ,  Anat Bashan ,  Tamar Auerbach ,  Matthew Belousoff ,  Liqun Xiong ,  Dorota Klepacki ,  Alexander S. Mankin

Inventor： Ada Yonath ,  Chen Davidovich ,  Ella Zimmerman ,  Anat Bashan ,  Tamar Auerbach ,  Matthew Belousoff ,  Liqun Xiong ,  Dorota Klepacki ,  Alexander S. Mankin

IPC: A61K31/7048 ,  A61K31/424 ,  A61K38/12 ,  A61P31/04 ,  A61K31/165 ,  A61K31/7056 ,  C07H17/08 ,  A61K31/366 ,  A61K31/215

CPC classification number: A61K31/365 ,  A61K31/424 ,  A61K31/7048 ,  A61K38/08 ,  A61K2300/00

Abstract: Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.

Abstract translation: 提供改进的抗生素类似物，以及基于结构晶体学分析设计的抗生素的协同组合以及包括这些改进的类似物和协同组合以及其生产和使用方法的药物组合物。 协同组合靶向核糖体中的相邻位点，证明相应的核糖体位点用于开发临床相关的协同抗生素的重要性。