公开(公告)号：US6040436A

公开(公告)日：2000-03-21

申请号：US713118

申请日：1996-09-16

申请人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David Joseph Shuey

发明人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David Joseph Shuey

IPC分类号： C07K14/705 ,  C07H21/02

CPC分类号： C07K14/705 ,  C07K2319/00 ,  Y10S435/81

摘要： Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.

公开(公告)号：US6140485A

公开(公告)日：2000-10-31

申请号：US452007

申请日：1999-11-30

申请人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David John Shuey

发明人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David John Shuey

IPC分类号： C07K14/705 ,  C07H21/02

CPC分类号： C07K14/705 ,  C07K2319/00 ,  Y10S435/81

摘要： Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.

摘要翻译： 公开了编码钙通道的三个亚基，α1B，α2δ和β3中的每一个的核酸。 还公开了含有编码亚基的核酸的载体; 含有编码亚基的核酸的宿主细胞; 分离编码相关钙通道亚基的核酸的方法; 亚基蛋白; 包含亚基蛋白的融合蛋白; 亚单位蛋白抗体; 用于鉴定调节钙通道活性的试剂的测定法和由此鉴定的试剂; 通过改变钙通道活性来治疗某些中枢神经系统疾病的方法; 以及诊断与特定钙通道相关疾病的方法，例如Lambert-Eaton综合征。