公开(公告)号：US6040436A

公开(公告)日：2000-03-21

申请号：US713118

申请日：1996-09-16

申请人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David Joseph Shuey

发明人： Rodrigo Franco ,  Ai Ru Sun Chen ,  David Joseph Shuey

IPC分类号： C07K14/705 ,  C07H21/02

CPC分类号： C07K14/705 ,  C07K2319/00 ,  Y10S435/81

摘要： Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.