公开(公告)号：US20100233278A1

公开(公告)日：2010-09-16

申请号：US12733900

申请日：2008-09-26

申请人： Akiko Ookawa ,  Yasushi Imada ,  Yasunari Shinkai ,  Hideaki Matsumoto

发明人： Akiko Ookawa ,  Yasushi Imada ,  Yasunari Shinkai ,  Hideaki Matsumoto

IPC分类号： A61K9/16 ,  A61K31/167 ,  A61P29/00

CPC分类号： A61K9/0056 ,  A61K9/2077

摘要： Provided is a solid preparation which rapidly disintegrates in the presence of saliva or a small amount of water in the oral cavity, particularly, a rapidly disintegrating solid preparation useful as an orally-disintegrating solid preparation.Specifically provided is a rapidly disintegrating solid preparation containing coated granules wherein saccharide or sugar alcohol having an average particle size of not less than 75 μm and a high dissolution rate is coated with cellulose, and a rapidly disintegrating solid preparation containing a) an active ingredient, b) saccharide or sugar alcohol having an average particle size of not less than 400 μm, c) cellulose and d) a disintegrant.

摘要翻译： 本发明提供一种固体制剂，其在口腔内唾液或少量水的存在下快速崩解，特别是用作口腔崩解固体制剂的快速崩解固体制剂。 具体提供的是含有包覆颗粒的快速崩解固体制剂，其中平均粒度不小于75μm，溶解速度高的糖或糖醇被纤维素包被，并且包含a）活性成分的快速崩解固体制剂， b）平均粒径不小于400μm的糖或糖醇，c）纤维素和d）崩解剂。

公开(公告)号：US20120171296A1

公开(公告)日：2012-07-05

申请号：US13419847

申请日：2012-03-14

申请人： Akiko OOKAWA ,  Yasushi IMADA ,  Yasunari SHINKAI ,  Hideaki MATSUMOTO

发明人： Akiko OOKAWA ,  Yasushi IMADA ,  Yasunari SHINKAI ,  Hideaki MATSUMOTO

IPC分类号： A61K9/14 ,  A61P25/04 ,  A61P29/00 ,  A61K31/167

CPC分类号： A61K9/0056 ,  A61K9/2077

摘要： Provided is a solid preparation which rapidly disintegrates in the presence of saliva or a small amount of water in the oral cavity, particularly, a rapidly disintegrating solid preparation useful as an orally-disintegrating solid preparation.Specifically provided is a rapidly disintegrating solid preparation containing coated granules wherein saccharide or sugar alcohol having an average particle size of not less than 75 μm and a high dissolution rate is coated with cellulose, and a rapidly disintegrating solid preparation containing a) an active ingredient, b) saccharide or sugar alcohol having an average particle size of not less than 400 μm, c) cellulose and d) a disintegrant.

摘要翻译： 本发明提供一种固体制剂，其在口腔内唾液或少量水的存在下快速崩解，特别是用作口腔崩解固体制剂的快速崩解固体制剂。 具体提供的是含有包覆颗粒的快速崩解固体制剂，其中平均粒度不小于75μm，溶解速度高的糖或糖醇被纤维素包被，并且包含a）活性成分的快速崩解固体制剂， b）平均粒径不小于400μm的糖或糖醇，c）纤维素和d）崩解剂。

公开(公告)号：US20140073671A1

公开(公告)日：2014-03-13

申请号：US14114429

申请日：2012-04-20

申请人： Shinji Narisawa ,  Masaaki Sugimoto ,  Kenichi Kitaoka ,  Akiko Ookawa ,  Masayuki Morimoto

发明人： Shinji Narisawa ,  Masaaki Sugimoto ,  Kenichi Kitaoka ,  Akiko Ookawa ,  Masayuki Morimoto

IPC分类号： A61K47/40 ,  A61K47/10 ,  A61K31/4545

CPC分类号： A61K47/40 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/5042 ,  A61K31/4545 ,  A61K47/10

摘要： Provided is an orally disintegrating tablet comprising a bitter-tasting pharmaceutically active ingredient in the form of bepotastine or a pharmacologically acceptable salt thereof that enables the bitter taste thereof to be masked, has both superior oral cavity disintegration and adequate hardness, and can be produced with ordinary tablet production equipment. The present invention relates to an orally disintegrating tablet containing bepotastine or a pharmacologically acceptable salt thereof, menthol or cyclodextrin, a water-insoluble polymer, and a disintegrating agent; and a method for producing an orally disintegrating tablet, comprising: 1) a step for obtaining granulated granules by mixing and granulating bepotastine or a pharmacologically acceptable salt thereof, a water-insoluble polymer, and optionally a vehicle, 2) a step for obtaining granules for tableting by mixing the granulated granules, menthol, a disintegrating agent, and optionally a lubricant and/or sweetener, and 3) a step for compressing the granules for tableting.

摘要翻译： 本发明提供一种口服崩解片剂，其包含苦味苦味的药物活性成分或其药理学上可接受的盐，其苦味可被掩蔽，具有优异的口腔分解和足够的硬度，并且可以与 普通平板电脑生产设备。 本发明涉及含有贝他辛胺或其药理学可接受的盐，薄荷醇或环糊精，水不溶性聚合物和崩解剂的口腔崩解片剂; 以及口腔崩解片的制造方法，其特征在于，包括：1）通过混合和制粒贝他辛胺或其药理学可接受的盐，水不溶性聚合物和任选的载体来获得粒状颗粒的步骤，2）获得颗粒的步骤 用于通过混合造粒颗粒，薄荷醇，崩解剂和任选的润滑剂和/或甜味剂的压片，以及3）压片用于压片的步骤。

公开(公告)号：US20110059980A1

公开(公告)日：2011-03-10

申请号：US12918580

申请日：2009-02-20

申请人： Yasuaki Oobayashi ,  Akiko Ookawa ,  Atsuko Hadama

发明人： Yasuaki Oobayashi ,  Akiko Ookawa ,  Atsuko Hadama

IPC分类号： A61K31/497

CPC分类号： A61K31/495 ,  A61K9/2018

摘要： Disclosed is a solid preparation for oral administration, which comprises cariprazine hydrochloride, in which lactose is used as the main excipient, and which enables the stable storage of cariprazine hydrochloride contained therein without the need of adding cyclodextrin.

摘要翻译： 公开了一种用于口服给药的固体制剂，其包括其中使用乳糖作为主要赋形剂的盐酸卡西拉嗪，并且其能够稳定地储存其中所含的盐酸卡匹嗪，而不需要加入环糊精。