公开(公告)号：US20120171296A1

公开(公告)日：2012-07-05

申请号：US13419847

申请日：2012-03-14

申请人： Akiko OOKAWA ,  Yasushi IMADA ,  Yasunari SHINKAI ,  Hideaki MATSUMOTO

发明人： Akiko OOKAWA ,  Yasushi IMADA ,  Yasunari SHINKAI ,  Hideaki MATSUMOTO

IPC分类号： A61K9/14 ,  A61P25/04 ,  A61P29/00 ,  A61K31/167

CPC分类号： A61K9/0056 ,  A61K9/2077

摘要： Provided is a solid preparation which rapidly disintegrates in the presence of saliva or a small amount of water in the oral cavity, particularly, a rapidly disintegrating solid preparation useful as an orally-disintegrating solid preparation.Specifically provided is a rapidly disintegrating solid preparation containing coated granules wherein saccharide or sugar alcohol having an average particle size of not less than 75 μm and a high dissolution rate is coated with cellulose, and a rapidly disintegrating solid preparation containing a) an active ingredient, b) saccharide or sugar alcohol having an average particle size of not less than 400 μm, c) cellulose and d) a disintegrant.

摘要翻译： 本发明提供一种固体制剂，其在口腔内唾液或少量水的存在下快速崩解，特别是用作口腔崩解固体制剂的快速崩解固体制剂。 具体提供的是含有包覆颗粒的快速崩解固体制剂，其中平均粒度不小于75μm，溶解速度高的糖或糖醇被纤维素包被，并且包含a）活性成分的快速崩解固体制剂， b）平均粒径不小于400μm的糖或糖醇，c）纤维素和d）崩解剂。