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    Method of preparing an antigen-containing formulation
    1.
    发明授权
    Method of preparing an antigen-containing formulation 有权
    制备含抗原制剂的方法

    公开(公告)号：US07815920B2

    公开(公告)日：2010-10-19

    申请号：US10211388

    申请日：2002-08-02

    Applicant: Alan Wheeler ,  Anthony Berry

    Inventor： Alan Wheeler ,  Anthony Berry

    IPC: A61K39/00

    CPC classification number: A61K39/39 ,  A61K2039/55572 ,  A61K2039/57

    Abstract: An antigen-containing formulation is provided, comprising: (a) an antigen; (b) a TH1-inducing adjuvant; and (c) a sparingly soluble amino acid or a derivative thereof. The adjuvant may be, for example, monophosphoryl lipid A, 3′-de-O-acetylated monophosphoryl lipid A, derivatives thereof, or any other adjuvant that enhances an individual's TH1 response to the antigen. Suitable amino acids include tyrosine, tryptophan, derivatives thereof, and the like. Methods for using the formulation are also provided; in a particularly preferred embodiment, the formulation is used as a vaccine.

    Abstract translation: 提供了含抗原的制剂，其包含：（a）抗原; （b）诱导TH1的佐剂; 和（c）微溶性氨基酸或其衍生物。 佐剂可以是例如单磷酰脂质A，3'-脱-O-乙酰化单磷酰脂质A，其衍生物或增强个体对抗原的TH1应答的任何其它佐剂。 合适的氨基酸包括酪氨酸，色氨酸，其衍生物等。 还提供了使用该制剂的方法; 在特别优选的实施方案中，该制剂用作疫苗。

    Testing method for permanent electrical removal of an integrated circuit output
    2.
    发明申请
    Testing method for permanent electrical removal of an integrated circuit output 失效
    用于永久电除去集成电路输出的测试方法

    公开(公告)号：US20070201293A1

    公开(公告)日：2007-08-30

    申请号：US11711450

    申请日：2007-02-26

    Applicant: Alan Wheeler

    Inventor： Alan Wheeler

    IPC: G11C17/18 ,  H03K19/007

    CPC classification number: G11C29/88 ,  G11C17/16 ,  G11C17/18 ,  G11C29/02 ,  G11C29/022 ,  G11C29/886

    Abstract: An apparatus and method of disconnecting or disabling an input/output terminal of an integrated circuit after packaging. Each input/output terminal of the integrated circuit includes a disabling device coupled thereto between the input/output terminal and the output driver of the respective input/output terminal. A DRAM module is disclosed having a plurality of partially good DRAM devices wherein the known bad input/output terminals are permanently disconnected using a disabling device, both the known good and known bad input/output terminals being coupled to conductive traces of a carrier substrate.

    Abstract translation: 封装后断开或禁用集成电路的输入/输出端子的装置和方法。 集成电路的每个输入/输出端子包括在输入/输出端子和相应输入/输出端子的输出驱动器之间耦合到其上的禁用装置。 公开了一种DRAM模块，其具有多个部分良好的DRAM器件，其中已知的不良输入/输出端子使用禁用器件永久断开，已知的良好和已知的不良输入/输出端子都耦合到载体衬底的导电迹线。

    Anti-allergic compositions and their use
    6.
    发明授权
    Anti-allergic compositions and their use 失效
    抗过敏组合物及其用途

    公开(公告)号：US4609547A

    公开(公告)日：1986-09-02

    申请号：US603666

    申请日：1984-04-26

    Applicant: Andrew J. Garman ,  Alan Wheeler

    Inventor： Andrew J. Garman ,  Alan Wheeler

    IPC: A61K31/195 ,  A61K38/00 ,  A61K39/35 ,  A61K39/385 ,  A61K39/36

    CPC classification number: A61K39/35 ,  Y10S424/805

    Abstract: Pharmaceutical compositions are described for anti-allergy therapy comprising an allergen or allergen extract, polysarcosine having an average molecular weight in the range of 2,000 to 12,000 and a chemical linking group connecting a reactive site on the polysarcosine to an amino group on the allergen or allergen extract, the reactive site on the polysarcosine being a H(CH.sub.3)N--, the allergen extract being an extract from an allergen selected from pollens, weeds, house dust mites and venoms, and the chemical linking group having the formula --CO--B--CO where B is a hydrocarbon chain of 1-4 carbon atoms. The disclosure also describes the analogous conjugates.

    Abstract translation: 描述了药物组合物用于包含变应原或变应原提取物的抗过敏疗法，平均分子量在2,000至12,000范围内的多肌氨酸和连接多肌氨酸上的反应部位与变应原或变应原上的氨基的化学连接基团 提取物，多糖肌氨酸的反应位点为H（CH3）N-，变应原提取物为选自花粉，杂草，房尘螨和毒液的变应原的提取物，以及具有式-CO-B的化学连接基团 -CO，其中B是1-4个碳原子的烃链。 本公开还描述了类似的缀合物。

    Antigen-containing formulation and methods of use thereof
    7.
    发明授权
    Antigen-containing formulation and methods of use thereof 有权
    含抗原的制剂及其使用方法

    公开(公告)号：US06440426B1

    公开(公告)日：2002-08-27

    申请号：US09399217

    申请日：1999-09-17

    Applicant: Alan Wheeler ,  Anthony Berry

    Inventor： Alan Wheeler ,  Anthony Berry

    IPC: A61K4500

    CPC classification number: A61K39/39 ,  A61K2039/55572 ,  A61K2039/57

    Abstract: An antigen-containing formulation is provided, comprising: (a) an antigen; (b) a TH1-inducing adjuvants; and (c) a sparingly soluble amino acid or a derivative thereof. The adjuvants may be, for example, monophosphoryl lipid A, 3′-de-O-acetylated monophosphoryl lipid A, derivatives thereof, or any other adjuvants that enhances an individual's TH response to the antigen. Suitable amino acids include tyrosine, tryptophan, derivatives thereof, and the like. Methods for using the formulation are also provided; in a particularly preferred embodiment, the formulation is used as a vaccine.

    Abstract translation: 提供了含抗原的制剂，其包含：（a）抗原; （b）诱导TH1的佐剂; 和（c）微溶性氨基酸或其衍生物。 佐剂可以是例如单磷酰脂质A，3'-脱-O-乙酰化单磷酰脂质A，其衍生物或增强个体对抗原的TH反应的任何其它佐剂。 合适的氨基酸包括酪氨酸，色氨酸，其衍生物等。 还提供了使用该制剂的方法; 在特别优选的实施方案中，该制剂用作疫苗。

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