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公开(公告)号：US20130142874A1
公开(公告)日：2013-06-06
申请号：US13481478
申请日：2012-05-25
Applicant: Alberto Reiner , Giorgio Reiner
Inventor： Alberto Reiner , Giorgio Reiner
IPC: A61K31/197
CPC classification number: A61K31/197 , A61K8/44 , A61K9/2009 , A61K31/196 , A61K47/02 , A61Q11/00
Abstract: New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or other side effects; in particular, these formulations permit to obtain in human patients higher Cmax of the active principle and shorter Tmax together with a lower coefficient of variation.
Abstract translation: 描述了相对于双氯芬酸，含有重量比为20至80的新型双氯芬酸口服用药物组合物和碱金属碳酸氢盐。 这些组合物完全可口，没有任何不愉快的味道或其他副作用; 特别地，这些制剂允许在人类患者中获得更高的活性成分的C max和较短的Tmax以及更低的变异系数。
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2.发明授权Device and composition for the delivery of a preservative-free balsamic cream 有权用于输送无防腐剂香脂奶油的装置和组合物公开(公告)号：US08039024B2
公开(公告)日：2011-10-18
申请号：US12358554
申请日：2009-01-23
Applicant: Alberto Reiner , Giorgio Reiner
Inventor： Alberto Reiner , Giorgio Reiner
IPC: A61K36/00
CPC classification number: A61K36/00 , A61K31/05 , A61K31/125 , A61K36/15 , A61K36/61 , A61K36/752
Abstract: A device and composition for delivering menthol, camphor, eucalyptus essential oils, and other essential oils with balsamic benefits, to be used for the relief of symptoms of common cold.
Abstract translation: 用于提供薄荷醇，樟脑，桉树精油和其他具有香脂益生精油的装置和组合物，用于缓解感冒症状。
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公开(公告)号：US07939561B2
公开(公告)日：2011-05-10
申请号：US11348634
申请日：2006-02-07
Applicant: Norman D. Schellenger , William R. Maichle , Carl L. Whatley, Jr. , Giorgio Reiner , Alberto Reiner
Inventor： Norman D. Schellenger , William R. Maichle , Carl L. Whatley, Jr. , Giorgio Reiner , Alberto Reiner
IPC: A61K31/185 , A61K31/19
CPC classification number: A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2866 , A61K31/195
Abstract: Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable tablet dosage forms. Also provided is packaging that discourages the use of rapidly bioavailable acute pain medications for off-label chronic pain treatment, and that allows such dosage forms to be manufactured and stored for prolonged periods of time.
Abstract translation: 提供快速生物可利用的急性疼痛药物的固体口服剂型，以及能够制备这种快速生物利用的片剂剂型的防潮包装。 还提供了包装，其不鼓励使用快速生物利用的急性疼痛药物用于非标签性慢性疼痛治疗，并且允许这种剂型长时间制造和储存。
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公开(公告)号：US07687542B2
公开(公告)日：2010-03-30
申请号：US11351611
申请日：2006-02-10
Applicant: Giorgio Reiner , Alberto Reiner
Inventor： Giorgio Reiner , Alberto Reiner
IPC: A61K31/185 , A61K31/19
CPC classification number: A61K31/195 , A61K9/2009 , A61K9/2866
Abstract: The present invention relates to excipients for the production of rapidly bioavailable solid oral dosage forms of diclofenac. In particular, the invention relates to the use of excipients that promote the bioavailability of such formulations, including alkaline buffering agents, gas forming excipients, hygroscopic excipients, water soluble diluents, wetting agents, and particular pharmaceutically acceptable salts.
Abstract translation: 本发明涉及用于生产快速生物可利用的双氯芬酸的固体口服剂型的赋形剂。 特别地，本发明涉及促进这些制剂的生物利用度的赋形剂的用途，包括碱性缓冲剂，形成气体的赋形剂，吸湿性赋形剂，水溶性稀释剂，润湿剂和特定的药学上可接受的盐。
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5.发明授权公开(公告)号：US07615547B2
公开(公告)日：2009-11-10
申请号：US10258004
申请日：2002-07-09
Applicant: Alberto Reiner
Inventor： Alberto Reiner
CPC classification number: A61K9/0095 , A61K9/1617 , A61K9/1623 , Y10S514/952
Abstract: A process is described for the preparation of granulates that contain liposoluble and hydrophobic substances, preferably steroidal substances, and that exhibit rapid and excellent water-dispersibility. The process comprises: a) the dispersion of substance (A) in water in the presence of a surfactant (B), b) the incorporation of a water-soluble polyhydroxylated solid excipient (C) in the aqueous dispersion until a granulable pasty mass is obtained and c) the granulation of the mass. The granulates so obtained are suitable for the preparation, at the time of use, of stable and homogeneous aqueous suspensions that are used for nutritional, cosmetic or, preferably, pharmaceutical purposes.
Abstract translation: 描述了用于制备含有脂溶性和疏水性物质（优选类固醇物质）的颗粒的制备方法，并表现出快速且优异的水分散性。 该方法包括：a）在表面活性剂（B）存在下物质（A）在水中的分散，b）将水溶性多羟基化固体赋形剂（C）加入到水分散体中，直到可糊状的糊状物质为 获得和c）质量的造粒。 如此获得的颗粒适合在使用时制备用于营养，化妆品或优选药物目的的稳定且均匀的水性悬浮液。
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Patent Agency Ranking
公开(公告)号：US4412996A
公开(公告)日：1983-11-01
申请号：US313311
申请日：1981-10-20
Applicant: Alberto Reiner
Inventor： Alberto Reiner
IPC: C07D213/66 , A61K31/435 , A61K31/44 , A61K31/4415 , A61K31/4418 , A61K31/4427 , A61K31/625 , A61P25/04 , A61P29/00 , B01J31/02 , C07B61/00 , C07D209/28 , C07D213/67 , C07D401/12 , C07D491/04 , C07D491/056
CPC classification number: C07D491/04 , C07D209/28 , C07D213/67
Abstract: The esters of pyridoxine and of isopropylidene pyridoxine with 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-indol-3-acetic acid and 5-(2,4-difluorophenyl)-salicylic acid are essentially endowed with the same activities of the corresponding acids and are less toxic and gastrolesive, whereby the therapeutical index is remarkably improved. For the preparation of these compounds the chloride of the acid is reacted with isopropylidene pyridoxine, followed by a hydrolysis to obtain the corresponding pyridoxine derivative.
Abstract translation: 吡哆醇和异丙叉基吡哆醇与1-（对氯苯甲酰基）-2-甲基-5-甲氧基 - 吲哚-3-乙酸和5-（2,4-二氟苯基） - 水杨酸的酯基本上赋予相同的 相应的酸的活性，毒性和胃肠毒性较小，治疗指数明显改善。 为了制备这些化合物，酸的氯化物与异丙叉基吡哆醇反应，随后水解得到相应的吡哆醇衍生物。
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7.发明申请公开(公告)号：US20110105613A1
公开(公告)日：2011-05-05
申请号：US12555975
申请日：2009-09-09
Applicant: Giorgio Reiner , Alberto Reiner
Inventor： Giorgio Reiner , Alberto Reiner
IPC: A61K31/196 , A61P29/00 , A61P19/02
CPC classification number: A61J3/00 , A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2866 , A61K31/195 , B65B1/04
Abstract: Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms.
Abstract translation: 提供了快速生物可利用的急性疼痛药物的固体口服剂型，以及能够制备这种快速生物利用剂型的防潮包装。
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8.发明授权公开(公告)号：US07482377B2
公开(公告)日：2009-01-27
申请号：US11132024
申请日：2005-05-18
Applicant: Alberto Reiner , Giorgio Reiner
Inventor： Alberto Reiner , Giorgio Reiner
IPC: A61K31/185 , A61K31/19
CPC classification number: A61K31/197 , A61K8/44 , A61K9/2009 , A61K31/196 , A61K47/02 , A61Q11/00
Abstract: New pharmaceutical compositions for oral use containing diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or other, side effects; in particular, these formulations permit to obtain in human patients higher Cmax of the active principle and shorter Tmax together with a lower coefficient of variation.
Abstract translation: 描述了相对于双氯芬酸，含有20至80重量％的双氯芬酸和碱金属碳酸氢盐的口服用新药物组合物。 这些组合物完全可口，没有任何不愉快的味道或其他副作用; 特别地，这些制剂允许在人类患者中获得更高的活性成分的C max和较短的Tmax以及更低的变异系数。
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9.发明申请公开(公告)号：US20070184107A1
公开(公告)日：2007-08-09
申请号：US11349008
申请日：2006-02-07
Applicant: Giorgio Reiner , Alberto Reiner
Inventor： Giorgio Reiner , Alberto Reiner
IPC: A61K9/20 , A61K31/195
CPC classification number: A61J3/00 , A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2866 , A61K31/195 , B65B1/04
Abstract: Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms.
Abstract translation: 提供了快速生物可利用的急性疼痛药物的固体口服剂型，以及能够制备这种快速生物利用剂型的防潮包装。
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公开(公告)号：US20060188565A1
公开(公告)日：2006-08-24
申请号：US11351611
申请日：2006-02-10
Applicant: Giorgio Reiner , Alberto Reiner
Inventor： Giorgio Reiner , Alberto Reiner
IPC: A61K31/195 , A61K9/48 , A61K9/20
CPC classification number: A61K31/195 , A61K9/2009 , A61K9/2866
Abstract: The present invention relates to excipients for the production of rapidly bioavailable solid oral dosage forms of diclofenac. In particular, the invention relates to the use of excipients that promote the bioavailability of such formulations, including alkaline buffering agents, gas forming excipients, hygroscopic excipients, water soluble diluents, wetting agents, and particular pharmaceutically acceptable salts.
Abstract translation: 本发明涉及用于生产快速生物可利用的双氯芬酸的固体口服剂型的赋形剂。 特别地，本发明涉及促进这些制剂的生物利用度的赋形剂的用途，包括碱性缓冲剂，形成气体的赋形剂，吸湿性赋形剂，水溶性稀释剂，润湿剂和特定的药学上可接受的盐。
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