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    Pharmaceutical composition containing an active ingredient and a micronised carrier/diluent
    4.
    发明授权
    Pharmaceutical composition containing an active ingredient and a micronised carrier/diluent 有权
    含有活性成分和微粉化载体/稀释剂的药物组合物

    公开(公告)号：US07670625B2

    公开(公告)日：2010-03-02

    申请号：US11627051

    申请日：2007-01-25

    申请人： Eva Trofast

    发明人： Eva Trofast

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0075 ,  A61K9/145 ,  A61K31/165 ,  Y10S514/951 ,  Y10S514/952

    摘要： The invention relates to a stable pharmaceutical composition useful in the treatment of respiratory disorders such as asthma, rhinitis and chronic obstructive pulmonary disease (COPD) and a novel micronisation process for manufacturing a stable formulation for formoterol or its enantiomers and a carrier/diluent comprising a carbohydrate such as lactose.

    摘要翻译： 本发明涉及用于治疗呼吸系统疾病如哮喘，鼻炎和慢性阻塞性肺疾病（COPD）的稳定药物组合物和用于制备福莫特罗或其对映异构体的稳定制剂的新型微粉化方法和载体/稀释剂，其包含 碳水化合物如乳糖。

    Medical Compositions for Intravesical Treatment of Bladder Cancer
    5.
    发明申请
    Medical Compositions for Intravesical Treatment of Bladder Cancer 审中-公开
    膀胱癌膀胱内治疗的医学成分

    公开(公告)号：US20070010570A1

    公开(公告)日：2007-01-11

    申请号：US11531535

    申请日：2006-09-13

    申请人： Bastiaan Nuijen ,  Ernie Pfadenhauer ,  Jos Beijnen

    发明人： Bastiaan Nuijen ,  Ernie Pfadenhauer ,  Jos Beijnen

    IPC分类号： A61K31/404

    CPC分类号： A61K9/19 ,  A61K9/0034 ,  A61K9/127 ,  A61K31/404 ,  Y10S514/908 ,  Y10S514/952 ,  Y10S514/97

    摘要： Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.

    摘要翻译： 公开了包含3-羟甲基-5-氮丙啶基-1,1-甲基-2- [1H-吲哚-4,7-二酮]丙烯醇（E09）的抗癌涂料组合物。 更具体地，涂料组合物包含EO9和配方载体。 配方载体改善了EO9的溶解性和稳定性。 另外，涂层组合物可以包括涂层剂，其在涂层组合物的膀胱内递送期间提供涂层组合物对膀胱壁的更好的粘附。

    Matrices formed of polymer and hydrophobic compounds for use in drug delivery
    6.
    发明授权
    Matrices formed of polymer and hydrophobic compounds for use in drug delivery 有权
    由聚合物和疏水化合物形成的矩阵用于药物递送

    公开(公告)号：US07160557B2

    公开(公告)日：2007-01-09

    申请号：US09730694

    申请日：2000-12-06

    申请人： Howard Bernstein ,  Donald Chickering ,  Sarwat Khattak ,  Julie Straub

    发明人： Howard Bernstein ,  Donald Chickering ,  Sarwat Khattak ,  Julie Straub

    IPC分类号： A61K9/10 ,  A61K9/16 ,  A61K47/30 ,  A61K47/24

    CPC分类号： A61K9/1617 ,  A61K9/1647 ,  Y10S514/951 ,  Y10S514/952

    摘要： A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.

    摘要翻译： 将脂质或其它疏水性或两亲性化合物（本文统称为“疏水性化合物”）整合到用于药物递送的聚合物基质中以改变药物释放动力学。 在药物是水溶性的实施方案中，与不将疏水化合物掺入聚合物材料的聚合物基质的释放相比，药物在更长的时间内释放。 与其中加入表面活性剂或脂质作为赋形剂的方法相反，疏水化合物实际上整合到聚合物基质中，从而改变水进入微粒的扩散并将溶解的药物扩散出基质。 整合的疏水化合物还延长了形成基质的水解不稳定聚合物的降解，进一步延缓了包封药物的释放。

    Pesticide composition containing finely ground amorphous silica
    10.
    发明授权
    Pesticide composition containing finely ground amorphous silica 有权
    包含精细研磨的无定形二氧化硅的农药组合物

    公开(公告)号：US06908629B2

    公开(公告)日：2005-06-21

    申请号：US10305897

    申请日：2002-11-27

    申请人： Jules Guerassimoff

    发明人： Jules Guerassimoff

    IPC分类号： A01N59/00 ,  A01N25/04 ,  A01N25/44 ,  A01N25/00

    CPC分类号： A01N59/00 ,  Y02A50/359 ,  Y10S514/875 ,  Y10S514/937 ,  Y10S514/951 ,  Y10S514/952 ,  A01N25/04 ,  A01N2300/00

    摘要： A pesticide composition contains a suspension of finely milled amorphous silica in water and optionally containing other ingredients. The composition can be sprayed onto a pest and/or the pest habitat to control the pest. The composition can control insects, flies, external and internal animal parasites, fungal organisms, worms, larvae and the like. The amorphous silica provides silica in a plant available format which provides an added benefit.

    摘要翻译： 农药组合物含有精细研磨的无定形二氧化硅在水中并任选地含有其它成分的悬浮液。 可以将组合物喷洒到害虫和/或害虫栖息地上以控制害虫。 组合物可以控制昆虫，苍蝇，外部和内部动物寄生虫，真菌生物，蠕虫，幼虫等。 无定形二氧化硅以植物可用的形式提供二氧化硅，这提供了附加的益处。