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公开(公告)号:US20090069334A1
公开(公告)日:2009-03-12
申请号:US12228559
申请日:2008-08-13
申请人: Julius Rebek, JR. , Shannon Biros , Lionel Moisan , Alessandro Volonterio , Enrique Mann , Trevor Dale
发明人: Julius Rebek, JR. , Shannon Biros , Lionel Moisan , Alessandro Volonterio , Enrique Mann , Trevor Dale
IPC分类号: A61K31/501 , C07D403/14 , A61P43/00
CPC分类号: C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要: The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet face” along one side and a hydrophobic face along the other side of the helix.
摘要翻译: 完成了模拟i,i + 3或i + 4,i + 7残基的新的α-螺旋支架的合成。 常见的哒嗪杂环来自容易获得的构建块6.这些支架可以被认为是具有沿着一侧具有“湿面”和沿着螺旋另一侧的疏水面的两亲性α-螺旋的合成对应物。