中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

9 records (took 0.01 seconds)

    POLYMORPHS OF ESZOPICLONE MALATE
    1.
    发明申请
    POLYMORPHS OF ESZOPICLONE MALATE 审中-公开
    异黄酮黄酮的多聚体

    公开(公告)号：US20080027223A1

    公开(公告)日：2008-01-31

    申请号：US11690580

    申请日：2007-03-23

    Applicant: Alex Mainfeld ,  Shlomit Wizel ,  Marioara Mendelovici ,  Anita Liberman ,  Tamas Koltai

    Inventor： Alex Mainfeld ,  Shlomit Wizel ,  Marioara Mendelovici ,  Anita Liberman ,  Tamas Koltai

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V.

    Abstract translation: 本发明提供结晶埃索替普罗苹果酸盐形式II，结晶埃索普洛尔形式V，从制备结晶依佐匹克隆苹果酸盐形式II或V的方法，包含结晶异山梨酸丙酮酸形式II或V的药物组合物和治疗失眠症的方法，包括施用结晶埃索普洛尔苹果酸盐形式 II或V.

    METHODS FOR PREPARING ESZOPICLONE CRYSTALLINE FORM A, SUBSTANTIALLY PURE ESZOPICLONE AND OPTICALLY ENRICHED ESZOPICLONE
    2.
    发明申请
    METHODS FOR PREPARING ESZOPICLONE CRYSTALLINE FORM A, SUBSTANTIALLY PURE ESZOPICLONE AND OPTICALLY ENRICHED ESZOPICLONE 审中-公开
    方法制备环磷酰胺形式A，物质纯度和光学强化剂

    公开(公告)号：US20070270590A1

    公开(公告)日：2007-11-22

    申请号：US11738115

    申请日：2007-04-20

    Applicant: Marioara MENDELOVICI ,  Anita LIBERMAN ,  Alex MAINFELD ,  Nina FINKELSTEIN

    Inventor： Marioara MENDELOVICI ,  Anita LIBERMAN ,  Alex MAINFELD ,  Nina FINKELSTEIN

    IPC: C07D487/02

    CPC classification number: C07D487/04

    Abstract: The present invention provides methods for preparing eszopiclone Form A, substantially chemically pure eszopiclone, or eszopiclone with low level(s) of residual solvent(s). The present invention also provides eszopiclone with low level(s) of residual solvent(s). The present invention also provides a process for optical enrichment of eszopiclone free base. For instance, one of the embodiments of the invention is directed to a method of preparing eszopiclone Form A, wherein the method comprises crystallizing eszopiclone free base from a solvent selected from the group consisting of isopropanol (IPA), methyl isobutyl ketone (MIBK), acetone, n-butanol, i-butanolisobutanol, 2-butanol, tetrahydrofuran (THF), dimethyl carbonate, methanol, ethanol, ethyl lactate, dimethylformamide (DMF), carbon tetrachloride, toluene, iso-butyl acetate and mixtures thereof.

    Abstract translation: 本发明提供了制备具有低水平的残留溶剂的依佐匹克A型，基本上化学纯的右佐佐普隆或舍佐匹克隆的方法。 本发明还提供了具有低水平的残留溶剂的依佐匹克隆。 本发明还提供了一种用于自由基佐佐匹克的光学富集的方法。 例如，本发明的一个实施方案涉及一种制备替佐氟曲霉A型的方法，其中所述方法包括从选自异丙醇（IPA），甲基异丁基酮（MIBK）， 丙酮，正丁醇，异丁醇异丁醇，2-丁醇，四氢呋喃（THF），碳酸二甲酯，甲醇，乙醇，乳酸乙酯，二甲基甲酰胺（DMF），四氯化碳，甲苯，乙酸异丁酯及其混合物。

    METHODS FOR PREPARING ESZOPICLONE CRYSTALLINE FORM A, SUBSTANTIALLY PURE ESZOPICLONE AND OPTICALLY ENRICHED ESZOPICLONE
    5.
    发明申请
    METHODS FOR PREPARING ESZOPICLONE CRYSTALLINE FORM A, SUBSTANTIALLY PURE ESZOPICLONE AND OPTICALLY ENRICHED ESZOPICLONE 审中-公开
    方法制备环磷酰胺形式A，物质纯度和光学强化剂

    公开(公告)号：US20100029943A1

    公开(公告)日：2010-02-04

    申请号：US12565971

    申请日：2009-09-24

    Applicant: Marioara MENDELOVICI ,  Anita LIBERMAN ,  Alex MAINFELD ,  Nina FINKELSTEIN

    Inventor： Marioara MENDELOVICI ,  Anita LIBERMAN ,  Alex MAINFELD ,  Nina FINKELSTEIN

    IPC: C07D471/04

    CPC classification number: C07D487/04

    Abstract: The present invention provides methods for preparing eszopiclone Form A, substantially chemically pure eszopiclone, or eszopiclone with low level(s) of residual solvent(s). The present invention also provides eszopiclone with low level(s) of residual solvent(s). The present invention also provides a process for optical enrichment of eszopiclone free base. For instance, one of the embodiments of the invention is directed to a method of preparing eszopiclone Form A, wherein the method comprises crystallizing eszopiclone free base from a solvent selected from the group consisting of isopropanol (IPA), methyl isobutyl ketone (MIBK), acetone, n-butanol, i-butanolisobutanol, 2-butanol, tetrahydrofuran (THF), dimethyl carbonate, methanol, ethanol, ethyl lactate, dimethylformamide (DMF), carbon tetrachloride, toluene, iso-butyl acetate and mixtures thereof.

    Abstract translation: 本发明提供了制备具有低水平的残留溶剂的依佐匹克A型，基本上化学纯的右佐佐普隆或舍佐匹克隆的方法。 本发明还提供了具有低水平的残留溶剂的依佐匹克隆。 本发明还提供了一种用于自由基佐佐匹克的光学富集的方法。 例如，本发明的一个实施方案涉及一种制备替佐氟曲霉A型的方法，其中所述方法包括从选自异丙醇（IPA），甲基异丁基酮（MIBK）， 丙酮，正丁醇，异丁醇异丁醇，2-丁醇，四氢呋喃（THF），碳酸二甲酯，甲醇，乙醇，乳酸乙酯，二甲基甲酰胺（DMF），四氯化碳，甲苯，乙酸异丁酯及其混合物。

Patent Agency Ranking