Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
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    发明申请
    Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs 有权
    用于药物固定和控释的结晶介孔氧化物基材料

    公开(公告)号:US20060134219A1

    公开(公告)日:2006-06-22

    申请号:US10562307

    申请日:2004-06-28

    IPC分类号: C01B33/12 A61K9/14

    摘要: The invention describes a new class of crystalline silica material having two levels or porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.

    摘要翻译: 本发明描述了一类具有两个等级或孔隙率和结构顺序的新型结晶二氧化硅材料。 在一级,建筑单位是具有沸石骨架的尺寸均匀的纳米尺度。 在第二结构层面,组装nanoslabs。 通过它们的角落,边缘或面部连接,这些图案通过与阳离子表面活性剂或三嵌段共聚物分子的相互作用 在这些分子抽真空之后,在纳米尺度内获得微孔,并且通过X射线衍射证明,纳米尺度之间的精确介孔取决于沸石纳米尺度的平铺图案。 这些材料可用于固定生物活性物质,如难溶性药物。