-
公开(公告)号：US20140296243A1
公开(公告)日：2014-10-02
申请号：US14126877
申请日：2012-06-15
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
-
公开(公告)号：US08492574B2
公开(公告)日：2013-07-23
申请号：US12591108
申请日：2009-11-09
申请人： Andre Charette , Alexandre Cote , Alexandre Lemire
发明人： Andre Charette , Alexandre Cote , Alexandre Lemire
IPC分类号： C07F3/06
CPC分类号： C07F3/06
摘要： There are provided methods for preparing diorganozinc compounds of formula R2Zn. For example, such a method can method comprise reacting together a compound of formula ZnX2 with at least one compound chosen from compounds of formulas RM1T, R2M1, and RM2. R, X, M1, M2, and T can be various different chemical entities. Compounds of formula R2ZnR3, in which R2 and R3 are the same or different, can also prepared in a similar manner.
摘要翻译： 提供了制备式R 2 Z n的二有机锌化合物的方法。 例如，这种方法可以包括使式ZnX 2的化合物与选自式RM1T，R2M1和RM2的化合物的至少一种化合物反应。 R，X，M1，M2和T可以是各种不同的化学实体。 其中R2和R3相同或不同的式R2ZnR3化合物也可以以类似的方式制备。
-
公开(公告)号：US20100121089A1
公开(公告)日：2010-05-13
申请号：US12591108
申请日：2009-11-09
申请人： Andre Charette , Alexandre Cote , Alexandre Lemire
发明人： Andre Charette , Alexandre Cote , Alexandre Lemire
IPC分类号： C07F3/06
CPC分类号： C07F3/06
摘要： There are provided methods for preparing diorganozinc compounds of formula R2Zn. For example, such a method can method comprise reacting together a compound of formula ZnX2 with at least one compound chosen from compounds of formulas RM1T, R2M1, and RM2. R, X, M1, M2, and T can be various different chemical entities. Compounds of formula R2ZnR3, in which R2 and R3 are the same or different, can also prepared in a similar manner
摘要翻译： 提供了制备式R 2 Z n的二有机锌化合物的方法。 例如，这种方法可以包括使式ZnX 2的化合物与选自式RM1T，R2M1和RM2的化合物的至少一种化合物反应。 R，X，M1，M2和T可以是各种不同的化学实体。 其中R2和R3相同或不同的式R2ZnR3化合物也可以以类似的方式制备
-
公开(公告)号：US09328117B2
公开(公告)日：2016-05-03
申请号：US14126877
申请日：2012-06-15
IPC分类号： A61K31/5025 , C07D487/04
CPC分类号： C07D487/04 , A61K31/5025
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
-
公开(公告)号：US20140005169A1
公开(公告)日：2014-01-02
申请号：US13990906
申请日：2011-12-02
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D513/20 , C07D498/10 , C07D487/10 , C07D495/22 , C07D495/14 , C07D495/20
CPC分类号： C07D513/20 , C07D487/10 , C07D495/14 , C07D495/20 , C07D495/22 , C07D498/04 , C07D498/10 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
-
-
-
-
搜索结果
5 条记录 (耗时 0.014 秒)
