公开(公告)号：US11268127B2

公开(公告)日：2022-03-08

申请号：US15116750

申请日：2015-02-04

申请人： Gabriel P. Lopez ,  Ashutosh Chilkoti ,  Ali Ghoorchian ,  Felipe Garcia Quiroz ,  Duke University

发明人： Gabriel P. Lopez ,  Ashutosh Chilkoti ,  Ali Ghoorchian ,  Felipe Garcia Quiroz

IPC分类号： C12Q1/37 ,  G01N33/573

摘要： The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.