公开(公告)号：US12065428B2

公开(公告)日：2024-08-20

申请号：US17932218

申请日：2022-09-14

申请人： Aligos Therapeutics, Inc. ,  Katholieke Universiteit Leuven

发明人： Dorothée Alice Marie-Eve Bardiot ,  Koen Vandyck ,  Sandro Boland ,  Antitsa Dimitrova Stoycheva ,  Arnaud Didier Marie Marchand ,  Pierre Jean-Marie Bernard Raboisson ,  Leonid Beigelman

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240182444A1

公开(公告)日：2024-06-06

申请号：US18487809

申请日：2023-10-16

申请人： Aligos Therapeutics, Inc. ,  Katholieke Universiteit Leuven

发明人： Dorothée Alice Marie-Eve Bardiot ,  Sandro Boland ,  Arnaud Didier Marie Marchand ,  Koen Vandyck ,  David McGowan ,  Leonid Beigelman

IPC分类号： C07D401/12 ,  A61P31/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

CPC分类号： C07D401/12 ,  A61P31/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240109871A1

公开(公告)日：2024-04-04

申请号：US18486759

申请日：2023-10-13

申请人： Aligos Therapeutics, Inc. ,  Katholieke Universiteit Leuven

发明人： Koen Vandyck ,  Dorothée Alice Marie-Eve Bardiot ,  Pierre Jean-Marie Bernard Raboisson ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Sandro Boland ,  Arnaud Didier Marie Marchand

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04

CPC分类号： C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240018126A1

公开(公告)日：2024-01-18

申请号：US18347099

申请日：2023-07-05

申请人： Aligos Therapeutics, Inc. ,  Katholieke Universiteit Leuven

发明人： Koen Vandyck ,  Dorothée Alice Marie-Eve Bardiot ,  Pierre Jean-Marie Bernard Raboisson ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Sandro Boland ,  Arnaud Didier Marie Marchand

IPC分类号： C07D403/12 ,  A61P31/14

CPC分类号： C07D403/12 ,  A61P31/14

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11845752B2

公开(公告)日：2023-12-19

申请号：US17450808

申请日：2021-10-13

申请人： ALIGOS THERAPEUTICS, INC.

发明人： Sandrine Vendeville ,  Yannick Debing ,  Antitsa Dimitrova Stoycheva ,  Pierre Jean-Marie Bernard Raboisson

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61K45/06 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K45/06 ,  C07D519/00

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230390242A1

公开(公告)日：2023-12-07

申请号：US18453887

申请日：2023-08-22

申请人： ALIGOS THERAPEUTICS, INC. ,  Emory University

发明人： Sandrine Vendeville ,  David Bernard Smith ,  Leonid Beigelman ,  Vladimir Serebryany ,  Raymond F. Schinazi ,  Franck Amblard ,  Leda Bassit

IPC分类号： A61K31/4025 ,  C07D405/12 ,  A61K31/40 ,  C07D207/34 ,  C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  A61K31/4192

CPC分类号： A61K31/4025 ,  C07D405/12 ,  A61K31/40 ,  C07D207/34 ,  C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  A61K31/4192

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230365970A1

公开(公告)日：2023-11-16

申请号：US18361363

申请日：2023-07-28

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/351 ,  C12N2310/315 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/322

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20230065527A1

公开(公告)日：2023-03-02

申请号：US17444947

申请日：2021-08-12

申请人： Aligos Therapeutics, Inc.

发明人： Tongfei Wu ,  Pierre Jean-Marie Bernard Raboisson ,  Francois Gonzalvez ,  Antitsa Dimitrova Stoycheva ,  Jerome Deval ,  Cheng Liu ,  Qingling Zhang

IPC分类号： C07D487/10 ,  C07D519/00 ,  C07D401/14 ,  C07D491/107 ,  C07D491/048 ,  C07D471/04

摘要： The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

公开(公告)号：US11549110B2

公开(公告)日：2023-01-10

申请号：US17672268

申请日：2022-02-15

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61P31/20 ,  A61K31/713 ,  A61K45/06

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20220009903A1

公开(公告)日：2022-01-13

申请号：US17303815

申请日：2021-06-08

申请人： Aligos Therapeutics, Inc. ,  Katholieke Universiteit Leuven

发明人： Koen Vandyck ,  Pierre Jean-Marie Bernard Raboisson ,  Leonid Beigelman ,  Vladimir Serebryany ,  Antitsa Dimitrova Stoycheva ,  Dorothée Alice Marie-Eve Bardiot ,  Sandro Boland ,  Arnaud Didier Marie Marchand

IPC分类号： C07D401/14 ,  A61K45/06 ,  A61K31/454 ,  C07D403/14 ,  A61K31/404 ,  C07D417/14 ,  A61K31/428 ,  A61K31/4178 ,  A61K31/675 ,  C07F9/6558 ,  C07D409/14 ,  C07D405/14 ,  C07D471/04 ,  A61K31/437 ,  A61P31/14

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.