公开(公告)号：US20080200376A1

公开(公告)日：2008-08-21

申请号：US11665127

申请日：2005-10-25

申请人： Malcolm MacCoss ,  Duncan E. MacIntyre ,  Alison M. Strack

发明人： Malcolm MacCoss ,  Duncan E. MacIntyre ,  Alison M. Strack

IPC分类号： A61K38/22 ,  A61K31/155 ,  A61K31/485 ,  A61K31/357 ,  A61K31/42 ,  A61K31/473 ,  A61K31/519 ,  A61P3/00 ,  A61P35/00 ,  A61P9/00 ,  A61P15/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to methods of treating and preventing obesity and obesity-related disorders in a subject comprising administering a neurokinin-1 antagonist and an anti-obesity agent, such as a melanocortin 4 receptor agonist, to said subject. The present invention further related to methods of treating or preventing sexual dysfunction, including male erectile dysfunction, in a subject comprising administering a neurokinin-1 antagonist and a sexual dysfunction therapeutic agent, such as a melanocortin 4 receptor agonist, to said subject. The present invention further provides for pharmaceutical compositions and medicaments useful in carrying out these methods.

摘要翻译： 本发明涉及治疗和预防受试者中肥胖和肥胖相关疾病的方法，包括向所述受试者施用神经激肽-1拮抗剂和抗肥胖剂如黑皮质素4受体激动剂。 本发明还涉及治疗或预防包括男性勃起功能障碍在内的性功能障碍的方法，所述方法包括向所述受试者施用神经激肽-1拮抗剂和性功能障碍治疗剂如黑皮质素4受体激动剂。 本发明进一步提供可用于实施这些方法的药物组合物和药物。