公开(公告)号：US07217515B2

公开(公告)日：2007-05-15

申请号：US10259326

申请日：2002-09-30

申请人： Allen W. Chiu ,  Yu-Lun Huang ,  Chen-Kung Chou

发明人： Allen W. Chiu ,  Yu-Lun Huang ,  Chen-Kung Chou

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Hepatoma up-regulated protein (HURP) gene serves as a useful molecular marker in the detection, preliminary screening and monitoring of bladder cancer in a human subject. A method for the detection of bladder cancer, in particular transitional cell carcinoma (TCC) of the bladder, in a human subject is disclosed, in which the detected expression of the human HURP gene in a sample taken from a subject suspected to have bladder cancer is indicative of the presence of the bladder cancer. The present invention further provides a non-invasive method for the detection, preliminary screening or monitoring of urinary TCC in a suspected subject, in which a urine sample taken from the subject is analyzed to determine an expression of the human HURP gene, the presence of which is indicative of the presence of urinary TCC.

摘要翻译： 肝癌上调蛋白（HURP）基因在人类受试者膀胱癌的检测，初步筛选和监测中起着有用的分子标记作用。 公开了一种在人类受试者中检测膀胱癌，特别是膀胱移行细胞癌（TCC）的方法，其中检测到来自怀疑患有膀胱癌的受试者的样品中人HURP基因的表达 表明膀胱癌的存在。 本发明还提供了用于检测，初步筛选或监测疑似受试者中的尿TCC的非侵入性方法，其中分析从受试者获取的尿液样品以确定人HURP基因的表达，存在 这表明尿TCC的存在。