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1.发明申请MULTIFUNCTIONAL ACRYLATES USED AS CROSS-LINKERS IN DENTAL AND BIOMEDICAL SELF-ETCHING BONDING ADHESIVES 有权多功能丙烯酸酯用作牙科和生物医学自我蚀刻粘合剂中的交联剂公开(公告)号：US20100197825A1
公开(公告)日：2010-08-05
申请号：US12362622
申请日：2009-01-30
CPC分类号： A61K6/083 , A61K6/0023 , C08L33/00
摘要： This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.
摘要翻译： 本发明描述了一种用于通过由钙 - 反应性胺和丙烯酸或甲基丙烯酸酯单体形成的分子桥将牙科和医用生物材料粘合到硬组织上的粘合剂，诸如搪瓷，牙本质和骨等硬组织。 该配方由具有多官能丙烯酸酯交联剂的酸稳定的可聚合化合物组成。 该配方在没有预先制备硬组织基材的情况下提供良好的自粘性。 制剂可以含有化学和/或光激活的自由基引发剂。
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2.发明申请NANO-ENCAPSULATED THERAPEUTICS FOR CONTROLLED TREATMENT OF INFECTION AND OTHER DISEASES 审中-公开用于控制感染和其他疾病治疗的纳米封闭治疗公开(公告)号：US20130089599A1
公开(公告)日：2013-04-11
申请号：US13492889
申请日：2012-06-10
申请人： Mauris N. DeSilva , Karen O'Connor , Amer Tiba
发明人： Mauris N. DeSilva , Karen O'Connor , Amer Tiba , Patty-Fu Giles
IPC分类号： A61K9/51
CPC分类号： A61K9/51 , A61K9/0024 , A61K9/1647 , A61K9/19 , A61K9/5153 , B82Y5/00 , Y10S977/773
摘要： This invention relates to a method to provide immediate, direct and controlled time release of an effective amount of therapeutics to a wound site for a prolonged period. The pharmaceutical formulation comprising a plurality of nanoparticles, said nanoparticles encapsulating a therapeutically effective amount of one or more antibacterial agents, and an application of the formulation to an implant before surgery provide for extended release of said antibacterial agents.
摘要翻译： 本发明涉及一种能够将有效量的治疗剂立即，直接和有控制地延长时间释放到伤口部位的方法。 包含多个纳米颗粒的药物制剂，所述纳米颗粒包封治疗有效量的一种或多种抗菌剂，并且在手术前将制剂施用于植入物提供所述抗菌剂的延长释放。
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3.发明授权公开(公告)号：US06677474B2
公开(公告)日：2004-01-13
申请号：US10071644
申请日：2002-02-07
申请人： Martin Hamer , Byoung In Suh , Amer Tiba
发明人： Martin Hamer , Byoung In Suh , Amer Tiba
IPC分类号： C07C6976
CPC分类号： C07C69/92 , A61K6/0023 , C07C67/08 , C08L35/06
摘要： Novel unsaturated esters for use in dentistry as bonding agents are produced by a reaction of a cyclic dianhydride with unsaturated alcohols. The novel unsaturated ester products have the formula: wherein R2 is H or CH3.
摘要翻译： 通过环状二酐与不饱和醇的反应制备用于牙科用作粘合剂的新型不饱和酯。 新型不饱和酯产物具有下式：其中R 2是H或CH 3。
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4.发明申请MULTIFUNCTIONAL ACRYLATES USED AS CROSS-LINKERS IN DENTAL AND BIOMEDICAL SELF-ETCHING BONDING ADHESIVES 审中-公开多功能丙烯酸酯用作牙科和生物医学自我蚀刻粘合剂中的交联剂公开(公告)号：US20120003611A1
公开(公告)日：2012-01-05
申请号：US13231301
申请日：2011-09-13
CPC分类号： A61K6/083 , A61K6/0023 , C08L33/00
摘要： This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.
摘要翻译： 本发明描述了一种用于通过由钙 - 反应性胺和丙烯酸或甲基丙烯酸酯单体形成的分子桥将牙科和医用生物材料粘合到硬组织上的粘合剂，诸如搪瓷，牙本质和骨等硬组织。 该配方由具有多官能丙烯酸酯交联剂的酸稳定的可聚合化合物组成。 该配方在没有预先制备硬组织基材的情况下提供良好的自粘性。 制剂可以含有化学和/或光激活的自由基引发剂。
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5.发明授权Multifunctional acrylates used as cross-linkers in dental and biomedical self-etching bonding adhesives 有权多功能丙烯酸酯用作牙科和生物医学自蚀刻粘合剂中的交联剂公开(公告)号：US08053487B2
公开(公告)日：2011-11-08
申请号：US12362622
申请日：2009-01-30
CPC分类号： A61K6/083 , A61K6/0023 , C08L33/00
摘要： This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.
摘要翻译： 本发明描述了一种用于通过由钙 - 反应性胺和丙烯酸或甲基丙烯酸酯单体形成的分子桥将牙科和医用生物材料粘合到硬组织上的粘合剂，诸如搪瓷，牙本质和骨等硬组织。 该配方由具有多官能丙烯酸酯交联剂的酸稳定的可聚合化合物组成。 该配方在没有预先制备硬组织基材的情况下提供良好的自粘性。 制剂可以含有化学和/或光激活的自由基引发剂。
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公开(公告)号：US06709271B2
公开(公告)日：2004-03-23
申请号：US09989601
申请日：2001-11-20
申请人： Rui Yin , Byoung In Suh , Louis Sharp , Amer Tiba
发明人： Rui Yin , Byoung In Suh , Louis Sharp , Amer Tiba
IPC分类号： A61C500
CPC分类号： A61K6/09 , A61K6/0073 , A61K6/083 , C08L75/16 , C08L33/00
摘要： Dental composite compositions, restorative compositions, and methods for their use are provided. The compositions can contain (a) from about 1 to about 35 weight percent of a monomer portion containing at least one monomer having a functional group capable of undergoing polymerization; (b) from about 75 to about 95 weight percent of a filler portion, the filler portion containing at least a spherical filler portion having at least one spherical filler particle component; and (c) from about 0.01 to about 10 weight percent of a polymerization catalyst portion containing at least one catalyst capable of assisting in the polymerization of the functional group of the monomer portion and hardening of the composite after application of the composite to a tooth surface or other dental surface. The spherical filler portion is present in an amount sufficient to reduce shrinkage of the composite after polymerization to about 1.8 percent or less. Compositions according to the invention are useful in Class I, II, IV, V, Core build-ups, and other types of dental restorations where maximum strength and polishability are desired. Methods for using such compositions in such restorative procedures are also provided.
摘要翻译： 提供牙科复合组合物，修复组合物及其使用方法。 组合物可以含有（a）约1至约35重量％的含有至少一个具有能够进行聚合的官能团的单体的单体部分; （b）约75至约95重量％的填料部分，所述填料部分至少包含具有至少一个球形填料颗粒组分的球形填料部分; 和（c）约0.01至约10重量％的含有至少一种催化剂的聚合催化剂部分，所述催化剂部分能够辅助单体部分的官能团的聚合，并且将复合材料施加到齿面上后使复合材料硬化 或其他牙齿表面。 球形填料部分的存在量足以减少聚合后复合材料的收缩率至约1.8％或更低。 根据本发明的组合物可用于需要最大强度和可抛光性的I类，II，IV，V，核心组合和其它类型的牙科修复体。 还提供了在这种修复方法中使用这些组合物的方法。
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公开(公告)号：US07649028B2
公开(公告)日：2010-01-19
申请号：US11700970
申请日：2007-01-24
申请人： Amer Tiba , David G. Charlton , James C. Ragain
发明人： Amer Tiba , David G. Charlton , James C. Ragain
CPC分类号： A61K6/0835 , C08L33/00
摘要： The invention relates to a temporary dental formulation useful as a durable, temporary restorative. The formulation changes color during mixing to assist the operator in ensuring adequacy of mixing and enhancing visualization during placement.
摘要翻译： 本发明涉及一种可用作耐用的临时性修复剂的临时牙齿配方。 配方在混合期间改变颜色，以帮助操作者确保混合的充分性和增强放置期间的可视化。
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公开(公告)号：US20070173559A1
公开(公告)日：2007-07-26
申请号：US11700970
申请日：2007-01-24
申请人： Amer Tiba , David G. Charlton , James C. Ragain
发明人： Amer Tiba , David G. Charlton , James C. Ragain
IPC分类号： A61K6/08
CPC分类号： A61K6/0835 , C08L33/00
摘要： The invention relates to a temporary dental formulation useful as a durable, temporary restorative. The formulation changes color during mixing to assist the operator in ensuring adequacy of mixing and enhancing visualization during placement.
摘要翻译： 本发明涉及一种可用作耐用的临时性修复剂的临时牙齿配方。 配方在混合期间改变颜色，以帮助操作者确保混合的充分性和增强放置期间的可视化。
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公开(公告)号：US06673958B2
公开(公告)日：2004-01-06
申请号：US10071641
申请日：2002-02-07
申请人： Amer Tiba , Martin Hamer , Byoung I. Suh
发明人： Amer Tiba , Martin Hamer , Byoung I. Suh
IPC分类号： C09K380
CPC分类号： A61K6/0023 , C07C271/16 , C08L33/00 , C08L35/08
摘要： Novel unsaturated esters for use in dentistry as bonding agents are produced by a stepwise reaction of a cyclic dianhydride with a) unsaturated alcohols, b) unsaturated glycidyl ethers, and c) unsaturated isocyanates. The products used as bonding agents have the formula: wherein R2 is H or CH3.
摘要翻译： 用于牙科用作粘合剂的新型不饱和酯通过环状二酐与a）不饱和醇，b）不饱和缩水甘油醚和c）不饱和异氰酸酯的逐步反应来制备。 用作粘合剂的产品具有下式：其中R 2是H或CH 3。
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