公开(公告)号：US06965904B2

公开(公告)日：2005-11-15

申请号：US09798257

申请日：2001-03-02

申请人： William E. Bankert ,  Jean-Luc Chatelain ,  Philippe Ciampossin ,  Eric Rodriguez ,  David Lee Smith ,  Amit Tewari

发明人： William E. Bankert ,  Jean-Luc Chatelain ,  Philippe Ciampossin ,  Eric Rodriguez ,  David Lee Smith ,  Amit Tewari

IPC分类号： G06F7/00 ,  G06F15/16 ,  G06F17/30 ,  H04B1/00

CPC分类号： G06F17/30657 ,  G06F17/30011 ,  Y10S707/99945

摘要： A method and computer program product for locating data in a system including a plurality of archive units, and answering a query directed to an archive unit. Locating includes broadcasting a query to all the archive units; identifying a set of the archive units that could contain a result for the query; receiving at least one query reply from the archive units; and validating the query reply when the archive unit that sent the query reply is in the set. Answering includes receiving the query; responding to the query when the archive unit could contain a result for the query; and discarding the query without responding when the archive unit could not contain a result for the query.

摘要翻译： 一种用于在包括多个存档单元的系统中定位数据并且回答指向归档单元的查询的方法和计算机程序产品。 查找包括向所有归档单元广播查询; 识别可以包含查询结果的一组归档单元; 从归档单元接收至少一个查询答复; 并在发送查询回复的归档单元在集合中时验证查询答复。 回答包括接收查询; 当归档单元可以包含查询的结果时响应查询; 并且当归档单元不能包含查询的结果时，丢弃查询而不响应。

公开(公告)号：US06750356B1

公开(公告)日：2004-06-15

申请号：US10308651

申请日：2002-12-02

申请人： Rajendra Singh Bhakuni ,  Amit Tewari ,  Tarun Singh ,  Suman P. S. Khanuja

发明人： Rajendra Singh Bhakuni ,  Amit Tewari ,  Tarun Singh ,  Suman P. S. Khanuja

IPC分类号： C07D32110

CPC分类号： C07D493/20

摘要： The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.

摘要翻译： 本发明提供一种在约4小时内从一锅中制备青蒿素中的arteether的方法，包括在新型多羟基催化剂的存在下，室温下，在乙醇中将少量的硼氢化钠还原成二氢青蒿素至二氢青蒿素，二氢青蒿素的酰化 在酸催化剂的存在下，使用1％乙酸乙酯在正己烷中从水性反应混合物中萃取芳烃，然后处理和纯化不纯的芳烃，得到80-86％（w / w）的纯α，β-丙烯醚 。

公开(公告)号：US06683193B2

公开(公告)日：2004-01-27

申请号：US10105964

申请日：2002-03-25

申请人： Rajendra Singh Bhakuni ,  Tarun Singh ,  Atul Prakash Kahol ,  Amit Tewari ,  Sundeep Tandon ,  Suman Preet Singh Khanuja

发明人： Rajendra Singh Bhakuni ,  Tarun Singh ,  Atul Prakash Kahol ,  Amit Tewari ,  Sundeep Tandon ,  Suman Preet Singh Khanuja

IPC分类号： C07D32300

CPC分类号： C07D493/20

摘要： The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.

摘要翻译： 本发明涉及一种制备蒿甲醚的改进方法。 从该方法制备的蒿甲醚可用于治疗不复杂，严重的复杂和多重耐药性疟疾。

公开(公告)号：US06337095B1

公开(公告)日：2002-01-08

申请号：US09538893

申请日：2000-03-30

申请人： Dharam Chand Jain ,  Neerja Pant ,  Madan Mohan Gupta ,  Rajendra Singh Bhakuni ,  Ram Kishor Verma ,  Sudeep Tandon ,  Shiv Kumar Gupta ,  Amit Tewari ,  Atul Prakash Kahol ,  Sushil Kumar

发明人： Dharam Chand Jain ,  Neerja Pant ,  Madan Mohan Gupta ,  Rajendra Singh Bhakuni ,  Ram Kishor Verma ,  Sudeep Tandon ,  Shiv Kumar Gupta ,  Amit Tewari ,  Atul Prakash Kahol ,  Sushil Kumar

IPC分类号： A01N6500

CPC分类号： C07D311/16

摘要： The invention relates to a process for the isolation of compound scopoletin which is used as nitric oxide synthesis inhibitor from Artemisia annua and other plant families, said process comprising extraction of dried powdered material of different plant parts with an aqueous acetonitrite solvent in the ratio of 1:5 for 6 to 8 hrs., concentration of the extracted solvent upto 30% of its original extract under vacuum, partitioning the concentrated extract with halogenated solvent to transfer scopoletin in the non-polar halogenated solvent, drying halogenated solvent over anhydrous sodium sulphate and evaporating the solvent, crystallizing the residues in methanol and filtering the crystals, concentrating the filtrate and chromatographed on silica gel, eluting scopoletin in chloroform methanol mixture; and crystallization of the fractions containing the scopoletin to get the pure scopoletin compound.

摘要翻译： 本发明涉及一种用于分离化合物番茄酱的方法，其用作来自青蒿和其他植物家族的一氧化氮合成抑制剂，所述方法包括用比例为1的丙酮酸溶剂萃取不同植物部分的干燥粉末材料 5℃6〜8小时，真空浓缩提取溶剂至30％原始萃取液，用卤代溶剂分配浓缩萃取液，在非极性卤代溶剂中转移香料，用无水硫酸钠干燥卤代溶剂， 蒸发溶剂，结晶甲醇残余物并过滤晶体，浓缩滤液并在硅胶上进行色谱分离，用氯仿甲醇混合物洗脱; 并将含有scopoletin的级分结晶，得到纯的scopoletin化合物。