公开(公告)号：US20100136635A1

公开(公告)日：2010-06-03

申请号：US12626843

申请日：2009-11-27

Applicant: Amrit Goswami ,  Kuladip Sarma ,  Ajit Kumar Hazarika

Inventor： Amrit Goswami ,  Kuladip Sarma ,  Ajit Kumar Hazarika

IPC: C12P17/02

CPC classification number: C12P17/02

Abstract: The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea hydrogen peroxide adduct (UHP) as oxidant and lipase enzyme as catalyst. Under the influence of lipase, the chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate is converted to per-acid in situ by the oxidant urea hydrogen peroxide which in turn transfers oxygen to olefin inducing chirality to the product epoxide. Using this technique, important epoxide building blocks of different industrially important compounds can be prepared with good yield and moderate enantioselectivity. Chiral epoxidation of olefins with environment friendly catalytic system that can be recycled is highly desirable in the context of Green Chemistry for preparation of many industrially important compounds.

Abstract translation: 本发明涉及使用新型手性酸2,3,4,6-二-O-异亚丙基-2-酮-L-古洛糖酸一水合物作为手性诱导剂和无水氢气从烯烃直接制备手性纯环氧化物的可循环方法 过氧化脲以尿素过氧化氢加合物（UHP）为氧化剂，脂肪酶为催化剂。 在脂肪酶的影响下，手性酸2,3：4,6-二-O-异亚丙基-2-酮-L-古洛糖酸一水合物通过氧化剂尿素过氧化氢原位转化为过酸， 氧气到烯烃诱导产物环氧化物的手性。 使用这种技术，可以以良好的产率和适度的对映选择性制备重要的不同工业重要化合物的环氧化物结构单元。 在环境友好的催化体系下可以循环使用的烯烃的手性环氧化在绿色化学方面是非常需要的，用于制备许多工业上重要的化合物。

公开(公告)号：US08148118B2

公开(公告)日：2012-04-03

申请号：US12626843

申请日：2009-11-27

Applicant: Amrit Goswami ,  Kuladip Sarma ,  Ajit Kumar Hazarika

Inventor： Amrit Goswami ,  Kuladip Sarma ,  Ajit Kumar Hazarika

IPC: C12P17/02 ,  C12N9/20

CPC classification number: C12P17/02

Abstract: The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea hydrogen peroxide adduct (UHP) as oxidant and lipase enzyme as catalyst. Under the influence of lipase, the chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate is converted to per-acid in situ by the oxidant urea hydrogen peroxide which in turn transfers oxygen to olefin inducing chirality to the product epoxide. Using this technique, important epoxide building blocks of different industrially important compounds can be prepared with good yield and moderate enantioselectivity. Chiral epoxidation of olefins with environment friendly catalytic system that can be recycled is highly desirable in the context of Green Chemistry for preparation of many industrially important compounds.

Abstract translation: 本发明涉及使用新型手性酸2,3,4,6-二-O-异亚丙基-2-酮-L-古洛糖酸一水合物作为手性诱导剂和无水氢气从烯烃直接制备手性纯环氧化物的可循环方法 过氧化脲以尿素过氧化氢加合物（UHP）为氧化剂，脂肪酶为催化剂。 在脂肪酶的影响下，手性酸2,3：4,6-二-O-异亚丙基-2-酮-L-古洛糖酸一水合物通过氧化剂尿素过氧化氢原位转化为过酸， 氧气到烯烃诱导产物环氧化物的手性。 使用这种技术，可以以良好的产率和适度的对映选择性制备重要的不同工业重要化合物的环氧化物结构单元。 在环境友好的催化体系下可以循环使用的烯烃的手性环氧化在绿色化学方面是非常需要的，用于制备许多工业上重要的化合物。

公开(公告)号：US06160139A

公开(公告)日：2000-12-12

申请号：US048279

申请日：1998-03-26

Applicant: Amrit Goswami ,  Rumi Kataky ,  Ramesh Chandra Rastogi ,  Anil C. Ghosh

Inventor： Amrit Goswami ,  Rumi Kataky ,  Ramesh Chandra Rastogi ,  Anil C. Ghosh

IPC: C07J7/00

CPC classification number: C07J7/00

Abstract: The invention relates to a process for the production of 16-dehydropregnenolone acetate of the formula ##STR1## comprising the oxidation of pseudodiosgenin diacetate in the presence of a phase transfer catalyst at a temperature between 0-15.degree. C. to produce diosone followed by the hydrolysis and degradation of diosone to produce 16-dehydropregnenolone acetate.

Abstract translation: 本发明涉及一种制备下式的16-脱氢孕烯醇酮醋酸酯的方法，该方法包括在相转移催化剂存在下在0-15℃的温度下氧化假二十二烷基二乙酸酯以产生二酮，接着水解和降解 的二酮以产生16-脱氢孕烯醇酮乙酸酯。