公开(公告)号：US5578661A

公开(公告)日：1996-11-26

申请号：US221159

申请日：1994-03-31

申请人： Adrian S. Fox ,  Amy E. Allen

发明人： Adrian S. Fox ,  Amy E. Allen

IPC分类号： A61L15/22 ,  A61L15/60 ,  A61L26/00 ,  C08L71/02 ,  C08L5/00 ,  C08L39/06

CPC分类号： A61L26/008 ,  A61L15/225 ,  A61L15/60 ,  A61L26/0052 ,  C08L71/02 ,  Y10S514/944

摘要： A gel forming system comprising an aqueous mixture of a first component of at least one water-soluble polymer in an amount sufficient to increase the initial viscosity of the mixture and impart adhesivity properties thereto; a second component of a acid-containing polymer; a third component of an amino-containing polymer; and water. This system has a pH in the range of between about 5.5 and 8.5 and the second and third components are each present in sufficient amounts which, in combination, increase the cohesiveness of the mixture over time, such that the mixture can be initially combined in a relatively fluid state and subsequently forms a cohesive gel structure. This system is useful as a wound dressing for deep wound cavities because the gel protects the wound and permits healing, does not interfere with new tissue growth or development, is capable of absorbing significant amounts of wound exudate, and has sufficient cohesive strength for subsequent removal from the cavity as an integral plug without interrupting the healing process.

摘要翻译： 一种凝胶形成系统，其包含至少一种水溶性聚合物的第一组分的水混合物，其量足以增加混合物的初始粘度并赋予其粘合性; 含酸聚合物的第二组分; 含氨基聚合物的第三组分; 和水。 该系统的pH值在约5.5至8.5之间，第二和第三组分各自以足够的量存在，其组合可以增加混合物随时间的凝聚性，使得混合物可以最初组合成 相对流体状态，随后形成凝聚凝胶结构。 该系统可用作深伤口腔的创伤敷料，因为凝胶保护伤口并允许愈合，不干扰新组织生长或发育，能够吸收大量的伤口渗出物，并具有足够的内聚强度用于随后的去除 从腔中作为整体插头，而不会中断愈合过程。