公开(公告)号：US20240285735A1

公开(公告)日：2024-08-29

申请号：US18657124

申请日：2024-05-07

申请人： MEDIWOUND LTD.

发明人： Evgenia LOZINSKY ,  Dafna GEBLINGER ,  Deborah Hanah BARTFELD ,  Eilon ASCULAI

IPC分类号： A61K38/48 ,  A61K9/06 ,  A61K47/36 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K38/4873 ,  A61K9/06 ,  A61K47/36 ,  A61L26/0052 ,  A61L26/008 ,  A61P17/02 ,  A61L2300/412

摘要： The present invention relates to compositions and methods of wound debridement and stimulation of granulation tissue formation, thereby preparing the wound bed to facilitate and promote the process of wound healing. In particular, the present invention relates to methods of debridement of chronic wounds by topically applying to a wound site or bed a composition containing a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, the composition being applied to the wound site or bed up to ten times over a period of up to four weeks, resulting in a clean wound bed covered with granulation tissue prepared towards wound healing.

公开(公告)号：US20240269344A1

公开(公告)日：2024-08-15

申请号：US18434544

申请日：2024-02-06

申请人： Chihiro KUBO ,  Naoki Satoh ,  Hidekazu Yaginuma

发明人： Chihiro KUBO ,  Naoki Satoh ,  Hidekazu Yaginuma

IPC分类号： A61L27/26 ,  A61L26/00

CPC分类号： A61L27/26 ,  A61L26/0052 ,  A61L26/0066 ,  A61L2300/414 ,  A61L2300/64

摘要： A method for producing porous carrier having high porosity that is excellent in shape retention can be performed. A porous structure is formed by: preparing a liquid mixture that has at least a first polypeptide and a second polypeptide; and adding transglutaminase to the liquid mixture, and allowing the resulting mixture to react to form a gel.

公开(公告)号：US12016968B2

公开(公告)日：2024-06-25

申请号：US17133089

申请日：2020-12-23

申请人： Cresilon, Inc.

发明人： Joseph A. Landolina ,  Omar M. Ahmad

IPC分类号： A61L26/00 ,  A61L15/22 ,  A61L15/42 ,  A61L15/58 ,  A61L24/00 ,  A61L24/04 ,  C08J3/075

CPC分类号： A61L26/0052 ,  A61L15/225 ,  A61L15/42 ,  A61L15/58 ,  A61L24/001 ,  A61L24/043 ,  A61L26/0066 ,  A61L26/008 ,  C08J3/075 ,  A61L2300/232 ,  A61L2300/236 ,  A61L2300/418 ,  C08J2305/04 ,  C08J2305/08 ,  A61L15/225 ,  C08L5/04 ,  A61L15/225 ,  C08L5/08 ,  A61L24/043 ,  C08L5/08 ,  A61L24/043 ,  C08L5/04

摘要： The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

公开(公告)号：US11952469B2

公开(公告)日：2024-04-09

申请号：US17219915

申请日：2021-04-01

申请人： National Taiwan University of Science and Technology

发明人： Hsieh-Chih Tsai ,  Shuian-Yin Lin ,  Hsiao-Ying Chou

IPC分类号： C08J3/075 ,  A61L26/00 ,  C08J3/24

CPC分类号： C08J3/075 ,  A61L26/0052 ,  A61L26/008 ,  C08J3/24 ,  C08J2305/04 ,  C08J2333/26 ,  C08J2371/02

摘要： The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

公开(公告)号：US11878083B2

公开(公告)日：2024-01-23

申请号：US17522126

申请日：2021-11-09

申请人： CONVATEC TECHNOLOGIES INC.

发明人： Lucy Louisa Ballamy ,  Sharon Lam Po Tang ,  Marion Herbe ,  Alan Rogers ,  Sean Kelly

IPC分类号： A61L15/22 ,  B29C48/05 ,  A61L26/00 ,  D01F4/00 ,  D01D5/06 ,  D01F8/02 ,  B29C48/88 ,  A61L15/44 ,  A61L15/60 ,  B29L31/00

CPC分类号： A61L15/225 ,  A61L15/44 ,  A61L15/60 ,  A61L26/0052 ,  B29C48/05 ,  B29C48/919 ,  D01D5/06 ,  D01F4/00 ,  D01F8/02 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/434 ,  B29K2005/00 ,  B29L2031/731 ,  A61L15/225 ,  C08L89/00 ,  A61L15/225 ,  C08L5/06 ,  A61L26/0052 ,  C08L5/06 ,  A61L26/0052 ,  C08L89/00

摘要： Multi component fibres for the reduction of the damaging activity of wound exudate components such as protein degrading enzymes and inflammatory mediators in wounds, the fibres comprising: from 10% to 100% by weight of the fibres of pectin and a sacrificial proteinaceous material in a weight ratio of 100:0 to 10:90 pectin to sacrificial proteinaceous material and from 0% to 90% by weight of the fibres of another polysaccharide or a water soluble polymer.

公开(公告)号：US20230381371A1

公开(公告)日：2023-11-30

申请号：US18033371

申请日：2022-03-11

申请人： SHANGHAI CHUANGSHI MEDICAL TECHNOLOGY (GROUP) CO, LTD

发明人： Qian CHEN ,  Litao FAN ,  Chengyu ZHANG ,  Yong YOU ,  Yajian WU

IPC分类号： A61L26/00

CPC分类号： A61L26/008 ,  A61L26/0066 ,  A61L26/0052 ,  A61L2300/204 ,  A61L2300/216 ,  A61L2300/602 ,  A61L2300/802

摘要： A polymer hydrogel with a slow-release function, and a preparation method and use thereof are provided. The polymer hydrogel includes the following components in mass percentage contents: 0.01% to 15% of an active ingredient, 0.01% to 15% of an ion inhibitor, 0.01% to 1% of a crosslinking agent, 0.1% to 10% of a polymer resin, 10% to 35% of a solvent, 0.1% to 15% of a skin-touch regulator, 10% to 55% of deionized water, 0.1% to 3% of an appearance modifier, 0.01% to 1% of a crosslinking regulator, 0.01% to 1% of a preservative, and 0.01% to 5% of a transdermal absorption enhancer. The polymer hydrogel prepared by the present disclosure has excellent skin adaptability and skin permeability, long drug slow-release time, and excellent bioadhesion to the skin, and can be repeatedly peeled off without residue.

公开(公告)号：US20230277721A1

公开(公告)日：2023-09-07

申请号：US18006061

申请日：2021-05-31

申请人： THERACION BIOMEDICAL CO., LTD.

发明人： Eun Jin KIM ,  Byung Nam KIM

IPC分类号： A61L26/00

CPC分类号： A61L26/0023 ,  A61L26/0052 ,  A61L26/009 ,  A61L2400/04 ,  A61L2300/418

摘要： A topical hemostatic powder composition and a preparation method for manufacturing the powder composition are disclosed. The powder-type hemostatic agent includes a superabsorbent polymer and a bioadhesive polymer (BP). The power-type hemostatic agent is biodegradable in vivo and superb in terms of hemostasis effectiveness, thereby suitable for various applications in surgical procedures and minimal invasive surgery such as endoscopy, laparoscopy, and the like.

公开(公告)号：US10071182B2

公开(公告)日：2018-09-11

申请号：US15256339

申请日：2016-09-02

申请人： Samuel E. Lynch ,  Leslie Wisner-Lynch

发明人： Samuel E. Lynch ,  Leslie Wisner-Lynch

IPC分类号： A61K38/18 ,  A61K47/42 ,  A61K9/70 ,  A61L26/00 ,  A61K9/00 ,  A61K47/34

CPC分类号： A61L26/0066 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/1858 ,  A61K47/34 ,  A61K47/42 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0052 ,  A61L26/0085 ,  A61L26/0095 ,  A61L2300/414 ,  A61P17/02 ,  Y02A50/473

摘要： Novel compositions for treating wounds and promoting the healing thereof are described, including composition containing novel combinations of a carrier and recombinant platelet derived growth factor having fewer isoforms and enhanced biostability. Methods of treating wounds with novel therapeutic composition using dosing procedures leading to effective results with a minimal number of treatment applications are also described.

公开(公告)号：US20180236020A1

公开(公告)日：2018-08-23

申请号：US15684440

申请日：2017-08-23

申请人： SAN MELIX LABORATORIES, INC.

发明人： KENNETH A. SABACINSKI ,  JOHN L. KAUFMAN

IPC分类号： A61K36/69 ,  A61K9/00 ,  A61K35/644 ,  A61K31/79 ,  A61K9/06 ,  A61L26/00 ,  A61K33/40 ,  A61K31/7034

CPC分类号： A61K36/69 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/7034 ,  A61K31/79 ,  A61K33/40 ,  A61K35/644 ,  A61K36/70 ,  A61L15/20 ,  A61L15/40 ,  A61L15/425 ,  A61L15/44 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0085 ,  A61L2300/204 ,  A61L2300/30 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61K2300/00

摘要： The present invention is a method of treating acute and chronic wounds and skin conditions. The product comprises a composition or formulation comprising a mixture of buckwheat honey and povidone-iodine. In one unique embodiment the composition is gelled. The composition is applied directly to a wound or a patient's skin or is impregnated on gauze or other similar material on a bandage or dressing for application to an exuding or non-exuding acute or chronic wound or skin condition.

公开(公告)号：US20180228904A1

公开(公告)日：2018-08-16

申请号：US15949956

申请日：2018-04-10

申请人： AHMET KILIC ,  HASAN CICEK

发明人： AHMET KILIC ,  HASAN CICEK

IPC分类号： A61K47/34 ,  A61K9/00 ,  A61K47/18 ,  A61K47/10 ,  A61K36/30 ,  A61K31/155 ,  A61K36/328 ,  A61L26/00 ,  A61K9/06 ,  A61K47/38 ,  A61K47/26

CPC分类号： A61K47/34 ,  A61K9/0014 ,  A61K9/006 ,  A61K9/06 ,  A61K31/155 ,  A61K36/30 ,  A61K36/328 ,  A61K47/10 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/38 ,  A61L26/0019 ,  A61L26/0023 ,  A61L26/0052 ,  A61L26/0057 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/206 ,  A61L2300/30 ,  A61L2300/404 ,  A61L2430/34 ,  A61K2300/00

摘要： The present invention relates to new formulations, particularly useful in the topical treatment of skin and orormucosal wounds. Formulations can be either a solution or a gel form consisting of a Polyhexamethylene biguanide as an antimicrobial agent, purified water and a tri-blockcopolymer, particularly a triblockcopolymer of polyethylene oxide and polypropylene oxide, and more particularly a poloxamer.