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公开(公告)号：US08198432B2
公开(公告)日：2012-06-12
申请号：US12462535
申请日：2009-08-05
申请人： Ravindra K. Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Stephanie Pincus, legal representative , Hani A. Nabi
发明人： Ravindra K. Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Hani A. Nabi
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/22 , A61K51/0485 , C07H17/02
摘要： This invention describes a first report on the synthesis of certain 124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
摘要翻译： 本发明描述了关于在660-800nm范围内具有长波长吸收的氯和细菌二氢红素相关的某些124I标记的光敏剂的合成的第一报告。 在初步研究中，这些化合物通过正电子发射断层扫描（PET）和光动力学治疗（PDT）治疗显示出巨大的潜力。 肿瘤成像或改进的光动力治疗剂本身的发展本身就是重要的一步，但双重功能试剂（PET成像和PDT）提供诊断身体扫描的潜力，然后进行靶向治疗。
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公开(公告)号：US07820143B2
公开(公告)日：2010-10-26
申请号：US12378751
申请日：2009-02-19
IPC分类号： A61B5/055
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译： 具有至少一个-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2或-N（CH 2 COOH）2基团的四酯类光敏剂化合物或其酯，所述四元醇化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或细菌嘌呤酰亚胺。 理想地，化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基，R 9是取代或未取代的-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2; 或-N（CH 2 COOH）2。 本发明还包括通过光注射化合物后用光处理的光动力学治疗方法和注射化合物后通过荧光成像的方法。
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公开(公告)号：US20110091390A1
公开(公告)日：2011-04-21
申请号：US12912033
申请日：2010-10-26
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1—R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译： 具有至少一个-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2或-N（CH 2 COOH）2基团的四酯类光敏剂化合物或其酯，所述四元醇化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或细菌嘌呤酰亚胺。 理想地，化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基，R 9是取代或未取代的-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2; 或-N（CH 2 COOH）2。 本发明还包括通过光注射化合物后用光处理的光动力学治疗方法和注射化合物后通过荧光成像的方法。
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公开(公告)号：US20090162289A1
公开(公告)日：2009-06-25
申请号：US12378751
申请日：2009-02-19
IPC分类号： A61K31/409 , A61P35/00 , A61K49/00 , A61K49/06
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译： 具有至少一个-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2或-N（CH 2 COOH）2基团的四酯类光敏剂化合物或其酯，所述四元醇化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或细菌嘌呤酰亚胺。 理想地，化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基，R 9是取代或未取代的-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2; 或-N（CH 2 COOH）2。 本发明还包括通过光注射化合物后用光处理的光动力学治疗方法和注射化合物后通过荧光成像的方法。
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5.发明申请公开(公告)号：US20060198783A1
公开(公告)日：2006-09-07
申请号：US11353626
申请日：2006-02-14
申请人： Ravindra Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Hani Nabi
发明人： Ravindra Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Hani Nabi
CPC分类号： A61K51/0485 , C07D487/22 , C07H17/02
摘要： This invention describes a first report on the synthesis of certain 124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
摘要翻译： 本发明描述了关于在660-800nm范围内具有长波长吸收的氯和细菌二氢红素相关的某些124 I-标记的光敏剂的合成的第一报告。 在初步研究中，这些化合物通过正电子发射断层扫描（PET）和光动力学治疗（PDT）治疗显示出巨大的潜力。 肿瘤成像或改进的光动力治疗剂本身的发展本身就是重要的一步，但双重功能试剂（PET成像和PDT）提供诊断身体扫描的潜力，然后进行靶向治疗。
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公开(公告)号：US20100184970A1
公开(公告)日：2010-07-22
申请号：US12462535
申请日：2009-08-05
申请人： Ravindra K. Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Hani A. Nabi , Stephanie Pincus
发明人： Ravindra K. Pandey , Munawwar Sajjad , Suresh Pandey , Amy Gryshuk , Allan Oseroff , Hani A. Nabi , Stephanie Pincus
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , A61K51/0485 , C07H17/02
摘要： This invention describes a first report on the synthesis of certain 124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
摘要翻译： 本发明描述了关于在660-800nm范围内具有长波长吸收的氯和细菌二氢红素相关的某些124I标记的光敏剂的合成的第一报告。 在初步研究中，这些化合物通过正电子发射断层扫描（PET）和光动力学治疗（PDT）治疗显示出巨大的潜力。 肿瘤成像或改进的光动力治疗剂本身的发展本身就是重要的一步，但双重功能试剂（PET成像和PDT）提供诊断身体扫描的潜力，然后进行靶向治疗。
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公开(公告)号：US07501509B2
公开(公告)日：2009-03-10
申请号：US11452511
申请日：2006-06-14
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a phamaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译： 具有至少一个-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2或-N（CH 2 COOH）2基团的四酯类光敏剂化合物或其酯，所述四元醇化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或细菌嘌呤酰亚胺。 理想地，化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基，R 9是取代或未取代的-CH 2 CH 2 CON（CH 2 CON（CH 2 COOH）2）2; 或-N（CH 2 COOH）2。 本发明还包括通过光注射化合物后用光处理的光动力学治疗方法和注射化合物后通过荧光成像的方法。
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公开(公告)号：US20070149497A1
公开(公告)日：2007-06-28
申请号：US11452511
申请日：2006-06-14
申请人： Ravindra Pandey , Amy Gryshuk , Lalit Goswami , William Potter , Allan Oseroff
发明人： Ravindra Pandey , Amy Gryshuk , Lalit Goswami , William Potter , Allan Oseroff
IPC分类号： A61K31/555 , C07D487/22 , A61K31/409
CPC分类号： C07D471/22 , A61K41/0071 , A61K41/0076 , C09B47/00 , C09B69/108
摘要： A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
摘要翻译： 具有至少一个侧基-CH 2 CH 2 CON（CH 2 CH 2）（CH 2）2 CH 3的四级光敏剂化合物， COOH）2）2或-N（CH 2 COOH）2个基团或其酯，所述四酯化合物为 二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，紫苏酰亚胺或细菌草甘膦酰亚胺。 该化合物具有下式：或其药学上可接受的衍生物，其中R 1 -R 8和R 10是各种取代基， 取代或未取代的-CH 2 CH 2 CON（CH 2 CH 2 CON（CH 2）2 CH 2） 2 CO 2）2）2
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