公开(公告)号：US07074904B2

公开(公告)日：2006-07-11

申请号：US09900379

申请日：2001-07-06

申请人： Hing C. Wong ,  Peter R. Rhode ,  Jon A. Weidanz ,  Susan Grammer ,  Ana C. Edwards ,  Pierre-Andre Chavaillaz ,  Jin-An Jiao

发明人： Hing C. Wong ,  Peter R. Rhode ,  Jon A. Weidanz ,  Susan Grammer ,  Ana C. Edwards ,  Pierre-Andre Chavaillaz ,  Jin-An Jiao

IPC分类号： C07K7/00 ,  C07K14/74 ,  C07K17/02

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70532 ,  C07K14/70539 ,  C07K14/77 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S530/868

摘要： The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.