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公开(公告)号：US08586573B2
公开(公告)日：2013-11-19
申请号：US12838771
申请日：2010-07-19
IPC分类号： A61K31/00 , A61K31/44 , A61K31/404 , C07D401/14 , C07D205/04
CPC分类号： C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention concerns compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z, Z1, Z2, Z3 and Z4 are as defined herein. The invention also concerns a process for the preparation of compounds of formula (I) and their therapeutic use.
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2.发明申请Derivatives of pyrrolopyridine-2-carboxamides, preparation thereof and therapeutic application thereof 有权吡咯并吡啶-2-甲酰胺的衍生物，其制备及其治疗应用公开(公告)号：US20090298865A1
公开(公告)日：2009-12-03
申请号：US12504770
申请日：2009-07-17
申请人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
发明人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I): Wherein n, the pyrrolopyridine core, X, Y and W are as described herein. The invention also relates to a preparation method and to a therapeutic application.
摘要翻译： 本发明涉及式（I）化合物：其中，n，吡咯并吡啶核心，X，Y和W如本文所述。 本发明还涉及制备方法和治疗应用。
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3.发明授权N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands 有权N-（杂芳基）-1H-吲哚-2-甲酰胺衍生物及其作为香草素TRPV1受体配体的用途公开(公告)号：US07557134B2
公开(公告)日：2009-07-07
申请号：US12143066
申请日：2008-06-20
申请人： Laurent Dubois , Yannick Evanno , Andre Malanda
发明人： Laurent Dubois , Yannick Evanno , Andre Malanda
IPC分类号： A61K31/404
CPC分类号： C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention concerns therapeutic uses of compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. Said compounds are ligands of the TRPV1 vanilloid receptor, and are therefore, useful for treating diseases associated with TRPV1 receptors, such as pain and inflammation among others as disclosed and specifically claimed.
摘要翻译： 本发明涉及通式（I）化合物的治疗用途，其中n，X1，X2，X3，X4，Z1，Z2，Z3，Z4，Z5和W如本文所定义。 所述化合物是TRPV1香草酸受体的配体，因此可用于治疗与TRPV1受体相关的疾病，例如所披露和具体要求保护的其它疼痛和炎症。
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4.发明申请N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 有权N-（氨基甲基）-1H-吲哚-2-羧酰胺衍生物，其制备方法及其治疗用途公开(公告)号：US20090156809A1
公开(公告)日：2009-06-18
申请号：US12358639
申请日：2009-01-23
申请人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
发明人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
IPC分类号： C07D403/12 , C07D401/12
CPC分类号： C07D401/12
摘要： The invention relates to compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z1, Z2, Z3, Z4, Ra and Rb are as defined herein. The invention also relates to process for the preparation of compounds of formula (I) and their therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物：其中n，X 1，X 2，X 3，X 4，Y，Z 1，Z 2，Z 3，Z 4，R a和R b如本文所定义。 本发明还涉及制备式（I）化合物及其治疗用途的方法。
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5.发明申请N-(ARYLALKYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF 有权N-（ARYLALKYL）-1H-吡咯并吡啶-2-羧酰胺衍生物，其制备和治疗用途公开(公告)号：US20080125459A1
公开(公告)日：2008-05-29
申请号：US11970886
申请日：2008-01-08
申请人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
发明人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention concerns compounds of general formula (I), wherein n, the pyrrolopyridine ring, X, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. The invention also concerns a method for preparing said compounds and their therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物，其中n，吡咯并吡啶环，X，Z 1，Z 2，Z 3， Z 4，Z 5和W如本文所定义。 本发明还涉及制备所述化合物及其治疗用途的方法。
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6.发明申请N-(HETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS VANILLOID TRPV1 RECEPTOR LIGANDS 有权N-（异丙基）-1H-吲哚-2-羧酰胺衍生物及其作为VANILLOID TRPV1受体配体的用途公开(公告)号：US20070259946A1
公开(公告)日：2007-11-08
申请号：US11765687
申请日：2007-06-20
申请人： Laurent Dubois , Yannick Evanno , Andre Malanda
发明人： Laurent Dubois , Yannick Evanno , Andre Malanda
IPC分类号： A61K31/405 , C07D209/42
CPC分类号： C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. Said compounds are ligands of the TRPV1 vanilloid receptor, and are therefore, useful for treating diseases associated with TRPV1 receptors, such as pain and inflammation.
摘要翻译： 本发明涉及通式（I）的化合物，其中n，X 1，X 2，X 3，X 4， Z 1，Z 2，Z 3，Z 4，Z 5， / SUB和W如本文所定义。 所述化合物是TRPV 1型香草酸受体的配体，因此可用于治疗与TRPV1受体相关的疾病，例如疼痛和炎症。
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7.发明授权N-(Heteroaryl)-1-heteroarylalky1-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof 有权N-（杂芳基）-1-杂芳基烷基] -1H-吲哚-2-甲酰胺衍生物，其制备和治疗用途公开(公告)号：US08735432B2
公开(公告)日：2014-05-27
申请号：US13658412
申请日：2012-10-23
申请人： Laurent Dubois , Yannick Evanno , Andre Malanda
发明人： Laurent Dubois , Yannick Evanno , Andre Malanda
IPC分类号： A61K31/44 , C07D401/02
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Y and W are as defined herein. The invention also concerns a method for preparing said compounds and their therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物，其中n，X1，X2，X3，X4，Y和W如本文所定义。 本发明还涉及制备所述化合物及其治疗用途的方法。
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8.发明申请N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEROF 有权N-（氨基甲基）-1H-吲哚-2-羧酰胺衍生物，其制备方法及其治疗用途公开(公告)号：US20120264944A1
公开(公告)日：2012-10-18
申请号：US13530261
申请日：2012-06-22
申请人： Laurent Dubois , Yannick Evanno , Andre Malanda
发明人： Laurent Dubois , Yannick Evanno , Andre Malanda
IPC分类号： C07D213/74
CPC分类号： C07D401/12
摘要： The invention relates to compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z1, Z2, Z3, Z4, Ra and Rb are as defined herein. The invention also relates to process for the preparation of compounds of formula (I) and their therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物：其中n，X 1，X 2，X 3，X 4，Y，Z 1，Z 2，Z 3，Z 4，R a和R b如本文所定义。 本发明还涉及制备式（I）化合物及其治疗用途的方法。
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9.发明申请N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof 有权N-（氨基杂芳基）-1H-吲哚-2-甲酰胺衍生物及其制备和治疗应用公开(公告)号：US20100286119A1
公开(公告)日：2010-11-11
申请号：US12838771
申请日：2010-07-19
IPC分类号： A61K31/4439 , A61K31/5377 , C07D401/04 , A61P31/22 , A61P17/06 , A61P17/00 , A61P13/00 , A61P15/00 , A61P29/00 , A61P1/00 , A61P3/10 , A61P25/24
CPC分类号： C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention concerns compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z, Z1, Z2, Z3 and Z4 are as defined herein. The invention also concerns a process for the preparation of compounds of formula (I) and their therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物：其中n，X 1，X 2，X 3，X 4，Y，Z，Z 1，Z 2，Z 3和Z 4如本文所定义。 本发明还涉及制备式（I）化合物及其治疗用途的方法。
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10.发明申请Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof 有权三环N-杂芳基 - 甲酰胺衍生物，其制备和治疗用途公开(公告)号：US20100173929A1
公开(公告)日：2010-07-08
申请号：US12696149
申请日：2010-01-29
申请人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
发明人： Laurent DUBOIS , Yannick EVANNO , Andre MALANDA
IPC分类号： A61K31/4375 , C07D471/14 , A61P29/00 , A61P13/00 , A61P31/22 , A61P25/24
CPC分类号： C07D471/04
摘要： The invention relates to tricyclic N-heteroaryl-carboxamide derivatives having the formula (I): Wherein A, P, W, Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, R3 and R3′ are as described herein. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
摘要翻译： 本发明涉及具有式（I）的三环N-杂芳基 - 甲酰胺衍生物：其中A，P，W，Z 1，Z 2，Z 3，Z 4，Z 5，Z 6，Z 7，Z 8，R 3和R 3'如本文所述。 本发明还涉及其制备方法及其治疗用途。
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