公开(公告)号：US07496489B2

公开(公告)日：2009-02-24

申请号：US11208303

申请日：2005-08-19

Applicant: Andrea M. Olland ,  James M. Wilhelm ,  Karl Malakian ,  Rayomand J. Unwalla

Inventor： Andrea M. Olland ,  James M. Wilhelm ,  Karl Malakian ,  Rayomand J. Unwalla

IPC: G06G7/48 ,  G01N33/50 ,  G06F19/00

CPC classification number: C07K14/721 ,  C07K2299/00

Abstract: This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the three-dimensional structural coordinates of the progesterone receptor and/or nonsteroidal ligands are disclosed.

Abstract translation: 本发明涉及孕酮受体/配体复合物，以及相关方法和软件系统。 公开了使用孕酮受体和/或非甾体配体的三维结构坐标设计和/或选择孕酮受体配体的方法。

公开(公告)号：US07155346B2

公开(公告)日：2006-12-26

申请号：US10209041

申请日：2002-07-31

Applicant: Andrea M. Olland ,  Mark L. Stahl ,  Francis X. Sullivan ,  Kathryn W. Underwood ,  Rajiv Chopra

Inventor： Andrea M. Olland ,  Mark L. Stahl ,  Francis X. Sullivan ,  Kathryn W. Underwood ,  Rajiv Chopra

IPC: G01N33/48 ,  C12Q1/48

CPC classification number: G01N25/147 ,  G06F19/70

Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.