公开(公告)号：US20100112028A1

公开(公告)日：2010-05-06

申请号：US11628993

申请日：2005-06-09

申请人： Klaus Hellerbrand ,  Michael Siedler ,  Andreas Schütz

发明人： Klaus Hellerbrand ,  Michael Siedler ,  Andreas Schütz

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K47/02 ,  A61K38/02 ,  B05D3/00 ,  A61P19/00

CPC分类号： A61L27/54 ,  A61L27/26 ,  A61L27/42 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/602

摘要： The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein/peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.

摘要翻译： 本发明涉及在体内具有骨诱导和骨传导性质的材料，其包含优选含有磷酸钙的陶瓷载体，以及活性剂，优选骨诱导蛋白/肽或药物和聚合物，其中活性剂均匀地涂覆 在载体上和聚合物内，其优选是可降解聚合物。 所述聚合物调节活性剂的释放动力学并保护其免受降解以延长体内半衰期。 此外，本发明涉及一种在体内生产具有骨诱导和骨传导性质的材料的方法。

公开(公告)号：US07331941B2

公开(公告)日：2008-02-19

申请号：US10821253

申请日：2004-04-08

申请人： Udo J. Vetter ,  Andreas Schütz ,  Joachim Glocker

发明人： Udo J. Vetter ,  Andreas Schütz ,  Joachim Glocker

IPC分类号： A61M5/32 ,  A61M5/00

CPC分类号： A61M5/3202 ,  A61M5/001 ,  A61M5/28 ,  A61M5/286 ,  A61M5/3204 ,  A61M5/348 ,  A61M2005/312

摘要： A hypodermic syringe has a hollow body adapted to hold a liquid, an inner cap fitted over an end of the body, and an axially extending needle seated in the inner cap and having an outer point projecting axially outward from the inner cap and an inner point projecting axially inward from the inner cap toward the body. An outer cap fittable over the inner cap and needle is connected to a clamp ring engageable around the inner cap by a frangible web. Interengaging formations on the ring and on the inner cap releasably retain the outer cap in an outer position spaced axially outward of the body and in which an interior of the outer cap is open to the exterior and an inner position spaced axially closely to the body and in which the interior of the outer cap is not open to the exterior.

摘要翻译： 皮下注射器具有适于容纳液体的中空体，装配在身体的端部上的内帽以及安置在内帽中的轴向延伸的针，并且具有从内帽轴向向外突出的外点和内点 从内盖朝向主体轴向向内突出。 内盖和针上的外盖可连接到夹紧环上，该夹环通过易碎的腹板与内盖接合。 在环上和内盖上的入口结构可释放地将外盖保持在主体轴向外侧隔开的外部位置，外盖的内部向外开放，内部位置与主体轴向地间隔开， 其中外盖的内部不向外部敞开。