公开(公告)号：US20240269372A1

公开(公告)日：2024-08-15

申请号：US18568337

申请日：2022-06-13

Applicant: Bristol-Myers Squibb Company

Inventor： Martin John McLoughlin ,  Mark Steven Howansky ,  George Tyler Currier ,  Peter William Heyman ,  Yuhong Wu ,  Erinc Sahin ,  Shreya Shashank Kulkarni ,  Ankur Sagar Kulshrestha ,  Xiaodong Chen ,  John Christian Knutsen ,  James William Kidner Bradford ,  Simon Francis Brereton ,  Timothy Donald Barrow-Williams ,  Christopher William Rosier ,  Jeffrey Nicholas Philippson ,  Carys Eleri Lee ,  Paul Antony Merritt

IPC: A61M5/00 ,  A61J1/20 ,  A61M5/14

CPC classification number: A61M5/001 ,  A61J1/2006 ,  A61M5/1408

Abstract: In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

公开(公告)号：US12048837B2

公开(公告)日：2024-07-30

申请号：US18063918

申请日：2022-12-09

Applicant: NOVARTIS AG

Inventor： Andrew Bryant ,  Heinrich Buettgen ,  Wolfgang Papst ,  Marie Picci

IPC: A61M5/00 ,  A61M5/28 ,  A61M5/315 ,  A61P27/02 ,  A61F9/00 ,  A61M5/31

CPC classification number: A61M5/31513 ,  A61M5/001 ,  A61M5/28 ,  A61M5/31505 ,  A61P27/02 ,  A61F9/0017 ,  A61M2005/3104 ,  A61M5/3137 ,  A61M2005/3139 ,  A61M2005/31508 ,  Y10T29/49826

Abstract: The invention provides a syringe for use in an ophthalmic injection. The syringe comprises a body, a stopper and a plunger. The body comprises an outlet at an outlet end and the stopper is arranged within the body such that a front surface of the stopper and the body define a variable volume chamber from which a fluid can be expelled though the outlet. The plunger comprises a plunger contact surface at a first end and a rod extends between the plunger contact surface and a rear portion. The plunger contact surface is arranged to contact the stopper but not couple thereto, such that the plunger can be used to force the stopper towards the outlet end of the body, reducing the volume of the variable volume chamber, but not to move the stopper away from the outlet end.

公开(公告)号：US20240165344A1

公开(公告)日：2024-05-23

申请号：US17992438

申请日：2022-11-22

Applicant: Becton, Dickinson and Company

Inventor： Shishir Prasad ,  Manish Kumar ,  Karthik MR

IPC: A61M5/32 ,  A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/001

Abstract: A needle cover includes a needle shield, a mount coupled to the needle shield, and a disinfecting pad coupled to the mount. The disinfecting pad is fixedly coupled to the needle shield with an adhesive, and wherein the disinfecting pad is a porous material impregnated with a disinfectant. The disinfecting pad is a precut foam having a plurality of columnar structures.

公开(公告)号：US11958647B2

公开(公告)日：2024-04-16

申请号：US17855912

申请日：2022-07-01

Applicant: Medline Industries, LP

Inventor： Kelly Kuehne ,  Curt Carpenter ,  Jessica Leginski

IPC: B65B55/10 ,  A61L2/10 ,  A61L2/20 ,  A61M5/00 ,  A61M5/31 ,  A61M5/315 ,  B65B3/00 ,  B65B55/02

CPC classification number: B65B55/10 ,  A61L2/10 ,  A61L2/206 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3129 ,  A61M5/31501 ,  B65B3/003 ,  B65B55/027

Abstract: A method of sterilizing a prefilled syringe comprises assembling a syringe assembly and performing at least one ethylene oxide (EtO) sterilization procedure cycle. The assembling step includes inserting a tip cap at a first end of a plunger, filling a non-glass barrel with sterilization sensitive material at a second end of the barrel, and inserting the plunger into the barrel at a second end to seal the sterilization sensitive material within the barrel. The EtO sterilization procedure cycle comprises undergoing a preprocessing stage, a wash and conditioning stage, an EtO sterilization stage and a wash and post exposure stage. Upon completing the EtO sterilization procedure cycle, a resultant pH of the sterilization-sensitive material does not exceed an acceptable pH range as defined by the United States Pharmacopeia. The disclosure also discusses inserting an assembled prefilled syringe into a procedure tray prior to performing the EtO sterilization procedure cycle.

公开(公告)号：US11786664B2

公开(公告)日：2023-10-17

申请号：US16996165

申请日：2020-08-18

Applicant: Medline Industries, LP

Inventor： Kelley Kuehne ,  John T. Bauer ,  Curt Carpenter ,  Jessica Leginski

IPC: A61M5/31 ,  B65B3/00 ,  B65B55/02 ,  A61J1/05 ,  A61M5/315 ,  A61M5/00 ,  A61M5/34 ,  A61M5/178

CPC classification number: A61M5/3134 ,  A61J1/05 ,  A61M5/3129 ,  B65B3/003 ,  B65B55/02 ,  A61L2202/182 ,  A61L2202/21 ,  A61L2202/24 ,  A61M5/001 ,  A61M5/178 ,  A61M5/31501 ,  A61M5/31515 ,  A61M5/347 ,  A61M2005/3104 ,  A61M2005/31508

Abstract: A syringe assembly may include a plunger having a stopper. A barrel may be configured to receive the plunger at an open first end. A tip cap may be removably attached to the second end and may form a chamber within the barrel between the plunger and tip cap. The chamber may be configured to contain a sterilization sensitive material. The barrel may be formed of a plastic material having a high barrier property configured to create a barrier between the sterilization sensitive material and gases produced for sterilization purposes such that the sterilization sensitive material remains unchanged during a sterilization procedure.

公开(公告)号：US20230310681A1

公开(公告)日：2023-10-05

申请号：US18330083

申请日：2023-06-06

Applicant: F. HOFFMANN-LA ROCHE AG ,  GENENTECH, INC.

Inventor： Markus HEMMINGER ,  Ulla GRAUSCHOPF ,  Frank BAMBERG ,  Mayumi BOWEN ,  Robert MÜLLER ,  Flora FELSOVALYI ,  Denny CHRISTENSEN

IPC: A61L2/20 ,  A61M5/00 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  B65B3/00 ,  B65B7/28 ,  B65B55/10

CPC classification number: A61L2/206 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/3202 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/10 ,  A61L2202/23 ,  A61M2005/3114 ,  A61M2205/0238 ,  A61M2207/10 ,  A61M2207/00 ,  A61L2202/24 ,  A61M5/31513 ,  A61M2005/3104 ,  B65B55/02

Abstract: A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111), and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle adaptor cap (12) has a rubber element (121) tightly sealing the orifice (113) of the tip (112) of the syringe barrel (11) and the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) is sterilized by a first sterilizing comprising a main step of exposing the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 5 hours to about 60 hours at a relative humidity of about 40% to about 100% and at a temperature of about 30° C. to about 60° C.; (ii) filling a drug substance (14) through the open end (111) of the syringe barrel (11) into an interior of the syringe barrel; (iii) sealing the interior of the syringe barrel (11) by advancing a rubber stopper (13) through the open end (111) of the syringe barrel (11); (iv) packaging the syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11); and (v) second external surface sterilizing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11). The rubber element (121) of the needle adaptor cap (12) and the rubber stopper (13) are made of a rubber material having a comparably low oxygen transmission rate such as, at 1 atmosphere, of not more than 64 cubic centimeter per square meter and day. The second external surface sterilizing comprises a main step of exposing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 3 hours to about 30 hours at a relative humidity of about 40% to about 100% and at a temperature of about 25° C. to about 45° C. At least one of the duration, the relative humidity and the temperature of the second external surface sterilizing is essentially lower than the respective duration, relative humidity or temperature of the first sterilization.

公开(公告)号：US11684720B2

公开(公告)日：2023-06-27

申请号：US17822074

申请日：2022-08-24

Applicant: Excelsior Medical Corporation

Inventor： William Anderson ,  Mark Wilson ,  Gary Henniger ,  Larry Colquitt ,  Christopher E. Gardner ,  Chirag S. Walawalkar

IPC: A61M5/315 ,  A61M5/31 ,  A61M25/04 ,  A61M39/02 ,  A61M39/16 ,  A61M39/20 ,  A61M5/00 ,  A61M5/34 ,  A61M25/00 ,  A61M39/10

CPC classification number: A61M5/31511 ,  A61M5/31 ,  A61M25/04 ,  A61M39/02 ,  A61M39/16 ,  A61M39/162 ,  A61M39/20 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3135 ,  A61M5/3137 ,  A61M5/31513 ,  A61M5/347 ,  A61M2005/3104 ,  A61M2005/31506 ,  A61M2025/0019 ,  A61M2039/1033

Abstract: An antiseptic medical cap that may include a base, a sidewall, and a chamber configured to receive a proximal end of a medical fluid port having an opening. The antiseptic medical cap, in some instances, may include an insert having a gas-releasing anti-microbial compound and/or include a nitric oxide-releasing system that is configured to be positioned at least partially through the opening of the medical fluid port when the antiseptic medical cap receives the proximal end of the medical fluid port into the chamber.

公开(公告)号：US11672967B2

公开(公告)日：2023-06-13

申请号：US16439127

申请日：2019-06-12

Applicant: Grove Group, LLC

Inventor： Nathan Gish ,  Ross Hudson ,  Josh Luttrell

IPC: A61M39/16 ,  A61L2/18 ,  A61M39/18 ,  A61M39/00 ,  A61M5/00 ,  A61M39/10

CPC classification number: A61M39/162 ,  A61L2/18 ,  A61M39/165 ,  A61M39/18 ,  A61L2202/24 ,  A61M5/001 ,  A61M2039/009 ,  A61M2039/1066 ,  A61M2039/1072

Abstract: A self-cleaning needleless connector may include a connector body defining a fluid passageway including an inlet and an outlet, a cover disposed over at least the inlet of the connector body, an access point disposed at an inlet end of the cover, where in a first position the inlet is within the cover and in an second position the inlet is extended beyond the cover and configured to receive a male luer, a reservoir containing a cleaning agent, and an abrasive surface located in the cover that is in fluid communication with the cleaning agent, where the abrasive surface and the cleaning agent are configured to contact an exterior surface of the inlet to create friction.

公开(公告)号：US20190240394A1

公开(公告)日：2019-08-08

申请号：US16384410

申请日：2019-04-15

Applicant: Genentech, Inc.

Inventor： Joshua Horvath ,  Lionel Vedrine ,  Nathan A. Goltz ,  Mukund R. Patel ,  Aaron D. Chesterman ,  Mayumi Naito Bowen

IPC: A61M5/00 ,  A61L31/04 ,  A61M5/20 ,  A61M5/145 ,  A61L2/08

CPC classification number: A61M5/001 ,  A61L2/08 ,  A61L2/087 ,  A61L31/048 ,  A61L2202/14 ,  A61L2202/181 ,  A61L2202/24 ,  A61M5/002 ,  A61M5/14586 ,  A61M5/1785 ,  A61M5/2033 ,  A61M2005/31588 ,  A61M2202/0413 ,  A61M2202/0486 ,  A61M2202/09 ,  A61M2205/0272

Abstract: Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region. The hollow region may reduce beam attenuation or reduce radiation absorption.

公开(公告)号：US20180264243A1

公开(公告)日：2018-09-20

申请号：US15925648

申请日：2018-03-19

Applicant: Silcor Biomed, LLC.

Inventor： Silvestre Cordoba ,  Frank A. Scarfone

IPC: A61F13/40 ,  A61M5/00 ,  A61F13/38

CPC classification number: A61M35/006 ,  A61F13/38 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3202 ,  A61M5/3204 ,  A61M2205/0205

Abstract: A system for integrating an antibacterial-element receptacle into an autoinjector cap facilitates the pre-injection treatment, the post-injection treatment, and prevents the accidental delivery of the injection. The system includes a cap assembly, an autoinjector body, and an antiseptic-soaked dressing. The cap assembly encloses the needle of the autoinjector and prevents the accidental trigger of the injection mechanism. The autoinjector body refers to the body of any conventional autoinjector. The antiseptic-soaked dressing is applied to the patient's skin prior to the delivery of the injection to disinfect and sterilize the injection area. The antiseptic-soaked dressing is housed in the cap assembly, between a receptacle and a removable cover. The removable is releasably mounted to the receptacle to allow access to the antiseptic-soaked dressing.