公开(公告)号：US08965520B2

公开(公告)日：2015-02-24

申请号：US10569054

申请日：2005-06-15

申请人： Andrew Botros ,  Bastiaan van Dijk ,  Matthijs Killian

发明人： Andrew Botros ,  Bastiaan van Dijk ,  Matthijs Killian

IPC分类号： A61N1/00 ,  A61B5/00 ,  A61B5/04 ,  A61N1/36

CPC分类号： A61N1/36036 ,  A61B5/04001 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7282 ,  A61N1/00 ,  A61N1/0541

摘要： Automatically analyzing neural activity. The method comprises: applying electrical stimulation to a target neural region at an initial current level that approximates a typical threshold-Neural Response Telemetry (NRT) level; recording an NRT measurement of neural activity within the target neural region in response to the stimulation; and utilizing a machine-learned expert system to predict, based on one or more features of the neural activity, whether the NRT measurement contains a neural response.

摘要翻译： 自动分析神经活动。 该方法包括：以近似典型阈值 - 神经反应遥测（NRT）水平的初始电流水平对目标神经区域施加电刺激; 记录目标神经区域内神经活动的NRT测量以响应刺激; 并且利用机器学习的专家系统基于神经活动的一个或多个特征来预测NRT测量是否包含神经反应。

公开(公告)号：US08880182B2

公开(公告)日：2014-11-04

申请号：US12809579

申请日：2008-12-17

申请人： Andrew Botros

发明人： Andrew Botros

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36032 ,  A61N1/36036 ,  A61N1/37252

摘要： A computer-implemented method for fitting a medical implant to a recipient, the medical implant being operative to stimulate a physiological system of the recipient over a plurality of stimulation channels. The method includes: determining, based on measurements, an initial stimulation profile for the plurality of stimulation channels; determining a representative stimulus level of the initial stimulation profile; determining a fitting stimulation profile by modifying the shape a shape of the initial stimulation based on the representative stimulus level profile; and configuring the medical implant according to the fitting stimulation profile.

摘要翻译： 一种用于将医疗植入物装配到受体的计算机实现的方法，所述医疗植入物可操作以通过多个刺激通道刺激接受者的生理系统。 该方法包括：基于测量确定多个刺激通道的初始刺激分布; 确定初始刺激分布的代表性刺激水平; 通过基于代表性的刺激水平分布来修改初始刺激的形状来确定拟合刺激分布; 以及根据拟合刺激特征配置医疗植入物。

公开(公告)号：US20100106218A1

公开(公告)日：2010-04-29

申请号：US12441273

申请日：2007-09-14

申请人： Andrew Botros

发明人： Andrew Botros

IPC分类号： A61F11/04 ,  A61N1/36

CPC分类号： A61B5/04001 ,  A61B5/0031 ,  A61B5/076 ,  A61B2560/0271 ,  A61N1/36036

摘要： A method for configuring a medical implant that stimulates a physiological system of a recipient of the medical implant is described where the medical implant includes at least one input configuration variable corresponding to a subjective characteristic of the physiological system. The configuration method includes measuring at least one physical characteristic of the physiological system to provide at least one objective physical measurement value and then determining the at least one input configuration variable to configure the medical implant by a predictive configuration model having as an input the at least one objective physical measurement value.

摘要翻译： 描述了用于配置刺激医疗植入物的接受者的生理系统的医疗植入物的方法，其中医疗植入物包括与生理系统的主观特征相对应的至少一个输入配置变量。 配置方法包括测量生理系统的至少一个物理特征以提供至少一个物理物理测量值，然后通过至少具有至少一个输入的输入的预测配置模型来确定至少一个输入配置变量来配置医疗植入物 一个客观物理测量值。

公开(公告)号：US20070112395A1

公开(公告)日：2007-05-17

申请号：US11555219

申请日：2006-10-31

申请人： Bastiaan van Dijk ,  Andrew Botros

发明人： Bastiaan van Dijk ,  Andrew Botros

IPC分类号： A61N1/00

CPC分类号： A61B5/04001 ,  A61N1/36036 ,  A61N1/37241 ,  A61N1/37247

摘要： The automatic measurement of evoked compound action potential (ECAP) thresholds of the auditory nerve; that is, a neural response, concurrently with the performance of psychophysics measurements of a prosthetic hearing implant recipient. During the fitting process, a stimulus signal comprising two components is applied to each stimulation channel. One signal component is configured to elicit an ECAP neural response, referred to herein as a neural response signal component. The other component is configured to elicit a response to a psychophysics stimulation, referred to herein as a psychophysics signal component. Indications of the psychophysics measurement and the concurrently obtained neural response measurements are provided to the user. For the psychophysics measurement, this includes the selected characteristics of the psychophysics signal component since the results of the applied stimulation is a recipient behavioral or auditory response.

摘要翻译： 诱发复合动作电位（ECAP）阈值的自动测量; 即神经反应，与假肢听力植入物接受者的心理物理学测量的性能同时进行。 在拟合过程中，将包括两个分量的刺激信号施加到每个刺激通道。 一个信号分量被配置为引出ECAP神经反应，这里称为神经反应信号分量。 另一个组件被配置为引发对心理物理学刺激的响应，这里被称为心理物理信号分量。 向用户提供心理物理学测量和同时获得的神经反应测量的指示。 对于心理物理学测量，这包括心理物理学信号分量的所选特征，因为所应用的刺激的结果是受体行为或听觉反应。

公开(公告)号：US20150126897A1

公开(公告)日：2015-05-07

申请号：US14590589

申请日：2015-01-06

申请人： Andrew Botros ,  Matthijs Killian ,  Bastiaan van Dijk

发明人： Andrew Botros ,  Matthijs Killian ,  Bastiaan van Dijk

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61B5/04

CPC分类号： A61N1/36036 ,  A61B5/04001 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7282 ,  A61N1/00 ,  A61N1/0541

摘要： Techniques for automatically analyzing neural activity within a target neural region. In one example, electrical stimulation is applied to the target neural region at an initial current level that approximates a typical threshold-Neural Response Telemetry (NRT) level. An NRT measurement of neural activity within the target neural region in response to the stimulation is recorded. A machine-learned expert system, which is configured with a decision tree that includes at least two levels of nodes which consider parameters relating to the NRT measurement, respectively, is utilized to predict, based on one or more features of the neural activity, whether the NRT measurement includes a neural response or does not include a neural response.

摘要翻译： 自动分析目标神经区域神经活动的技术。 在一个示例中，电刺激以近似典型阈值 - 神经响应遥测（NRT）水平的初始电流电平施加到目标神经区域。 记录了针对刺激的目标神经区域内的神经活动的NRT测量。 机器学习专家系统被配置有分别包括考虑与NRT测量相关的参数的至少两个级别的节点的决策树，用于基于神经活动的一个或多个特征来预测是否 NRT测量包括神经反应或不包括神经反应。

公开(公告)号：US20130204325A1

公开(公告)日：2013-08-08

申请号：US13365017

申请日：2012-02-02

申请人： Andrew BOTROS

发明人： Andrew BOTROS

IPC分类号： A61N1/36 ,  G06F15/00 ,  A61F11/04

CPC分类号： H04R25/70 ,  A61N1/0541 ,  A61N1/36 ,  A61N1/36036 ,  G06F15/00

摘要： A method for determining a first set of one or more parameters for configuring a system, the method including evaluating a behavior of the system over a predetermined selection of parameter values for a second set of parameters, and deriving a first set of one or more parameters to configure the system based on the evaluated behavior of the system, wherein the number of parameters in the first set is less than the number of parameters in the second set.

摘要翻译： 一种用于确定用于配置系统的一个或多个参数的第一组的方法，所述方法包括：针对第二参数组的参数值的预定选择来评估所述系统的行为，以及导出第一组一个或多个参数 基于所述系统的评估行为来配置所述系统，其中所述第一组中的参数的数量小于所述第二组中的参数的数量。

公开(公告)号：US08190268B2

公开(公告)日：2012-05-29

申请号：US12965531

申请日：2010-12-10

申请人： Andrew Botros ,  Bas van Dijk

发明人： Andrew Botros ,  Bas van Dijk

IPC分类号： A61N1/00

CPC分类号： A61B5/04001 ,  A61N1/36036

摘要： A method of fitting to a recipient a cochlear implant including a plurality of stimulation channels. The method comprises applying to at least one stimulation channel of the cochlear implant a first stimulus signal comprising a neural response component and a psychophysics signal component, automatically measuring a strength of an evoked compound action potential (ECAP) of the recipient evoked in response to the application of the neural response component of the first stimulus signal, and simultaneously providing to a user an indication of the automatically measured strength of the ECAP and a value of the applied psychophysics signal component.

摘要翻译： 一种将接收器装配到包括多个刺激通道的耳蜗植入物的方法。 所述方法包括将耳蜗植入物的至少一个刺激通道应用于包括神经反应部件和心理物理学信号分量的第一刺激信号，自动测量响应于所述受体诱发的受体诱发的复合动作电位（ECAP）的强度 应用第一刺激信号的神经反应分量，并且同时向用户提供自动测量的ECAP的强度和所应用的心理物理信号分量的值的指示。

公开(公告)号：US20120226331A1

公开(公告)日：2012-09-06

申请号：US13037453

申请日：2011-03-01

申请人： Rami Banna ,  Andrew Botros

发明人： Rami Banna ,  Andrew Botros

IPC分类号： A61N1/05

CPC分类号： A61N1/36036 ,  A61N1/0541 ,  A61N1/37217

摘要： The present application discloses systems and methods for distributed processing of electrophysiological signals. The system may include a processor, a remote device, and an implant comprising an array of electrodes. The method may comprise the processor receiving an electrophysiological signal request from the remote device that specifies at least one electrode at the implant from which to receive an electrophysiological signal, transmitting to the implant instructions to apply a plurality of stimuli via the specified at least one electrode and, for individual stimuli in the plurality of stimuli, recording an electrophysiological signal component resulting from the stimulus. The method may also comprise the processor combining the recorded individual electrophysiological signal components to produce the electrophysiological signal and transmitting the electrophysiological signal to the remote device for further processing. In some embodiments of the method, the processor may compress the electrophysiological signal before transmitting it to the remote device.

摘要翻译： 本申请公开了用于电生理信号的分布式处理的系统和方法。 该系统可以包括处理器，远程设备和包括电极阵列的植入物。 该方法可以包括处理器从远程设备接收电生理信号请求，其指定在植入处的至少一个电极从其接收电生理信号，传送到植入指令以经由指定的至少一个电极施加多个刺激 并且对于多个刺激中的个体刺激，记录由刺激产生的电生理信号分量。 该方法还可以包括处理器组合记录的各个电生理信号分量以产生电生理信号，并将电生理信号发送到远程设备用于进一步处理。 在该方法的一些实施例中，处理器可以在将其发送到远程设备之前压缩电生理信号。

公开(公告)号：US20120197065A1

公开(公告)日：2012-08-02

申请号：US13016315

申请日：2011-01-28

申请人： Andrew Botros ,  Bastiaan van Dijk ,  Rami Banna

发明人： Andrew Botros ,  Bastiaan van Dijk ,  Rami Banna

IPC分类号： H04R25/00 ,  A61N1/00 ,  A61F2/18

CPC分类号： A61N1/36032 ,  A61N1/36036 ,  A61N1/37247 ,  H04R25/70

摘要： The present application discloses systems and methods for displaying and operating a user interface having one or more channel group controllers corresponding to one or more groups of hearing prosthesis channels. The hearing prosthesis may be configured to generate a plurality of signals via a plurality of channels based on a channel profile. The channel profile may define at least one intensity level for each channel. In operation, the user interface may be configured to instruct the hearing prosthesis to change the channel profile of the plurality of channels in response to receiving an input via one of the channel group controllers. The user interface may be used to fit a hearing prosthesis to a recipient. In one embodiment, an initial channel profile may be automatically determined, and the prosthesis channel profile may be adjusted by changing a representative intensity level corresponding to the channel profile.

摘要翻译： 本申请公开了用于显示和操作具有对应于一组或多组听觉假体通道的一个或多个通道组控制器的用户界面的系统和方法。 听觉假体可以被配置为基于信道简档来经由多个信道生成多个信号。 信道简档可以为每个信道定义至少一个强度级别。 在操作中，用户接口可以被配置为响应于经由信道组控制器中的一个接收到输入而指示听觉假体改变多个信道的信道简档。 用户界面可以用于将听觉假体装配到接收者。 在一个实施例中，可以自动确定初始信道简档，并且可以通过改变与信道简档对应的代表性强度级别来调整假体信道简档。

公开(公告)号：US20110082521A1

公开(公告)日：2011-04-07

申请号：US12965531

申请日：2010-12-10

申请人： Andrew Botros ,  Bastiaan van Dijk

发明人： Andrew Botros ,  Bastiaan van Dijk

IPC分类号： A61N1/00

CPC分类号： A61B5/04001 ,  A61N1/36036

摘要： A method of fitting to a recipient a cochlear implant including a plurality of stimulation channels. The method comprises applying to at least one stimulation channel of the cochlear implant a first stimulus signal comprising a neural response component and a psychophysics signal component, automatically measuring a strength of an evoked compound action potential (ECAP) of the recipient evoked in response to the application of the neural response component of the first stimulus signal, and simultaneously providing to a user an indication of the automatically measured strength of the ECAP and a value of the applied psychophysics signal component.

摘要翻译： 一种将接收器装配到包括多个刺激通道的耳蜗植入物的方法。 所述方法包括将耳蜗植入物的至少一个刺激通道应用于包括神经反应部件和心理物理学信号分量的第一刺激信号，自动测量响应于所述受体诱发的受体诱发的复合动作电位（ECAP）的强度 应用第一刺激信号的神经反应分量，并且同时向用户提供自动测量的ECAP的强度和所应用的心理物理信号分量的值的指示。